The function of juvenile-adult transition axis in female sexual receptivity of Drosophila melanogaster DOI Open Access

Jing Li,

Chao Ning,

Yaohua Liu

и другие.

Опубликована: Авг. 22, 2024

Female sexual receptivity is essential for reproduction of a species. Neuropeptides play the main role in regulating female receptivity. However, whether neuropeptides regulate during neurodevelopment unknown. Here we found peptide hormone prothoracicotropic (PTTH), which belongs to insect PG axis, negatively regulated virgin through ecdysone Drosophila melanogaster . We identified PTTH neurons as doublesex-positive neurons, they before metamorphosis 3 rd -instar larval stage. deletion resulted increased EcR-A expression whole newly formed prepupae. Furthermore, receptor pC1 positively metamorphosis. The decreased induced abnormal morphological development without changing neural activity. Among all subtypes function pC1b was necessary copulation rate. These suggested that changes synaptic connections between and other Moreover, significantly when Torso reduced neurons. This not only regulates but also affecting associated directly. axis has similar functional strategy HPG mammals trigger juvenile–adult transition. Our work suggests general mechanism underlying maturation

Язык: Английский

A Drosophila computational brain model reveals sensorimotor processing DOI Creative Commons
Philip K. Shiu, Gabriella R Sterne, Nico Spiller

и другие.

Nature, Год журнала: 2024, Номер 634(8032), С. 210 - 219

Опубликована: Окт. 2, 2024

Язык: Английский

Процитировано

19
Connectomics and the neural basis of behaviour DOI Creative Commons
Dana S. Galili, Gregory S.X.E. Jefferis, Marta Costa

и другие.

Current Opinion in Insect Science, Год журнала: 2022, Номер 54, С. 100968 - 100968

Опубликована: Сен. 13, 2022

Methods to acquire and process synaptic-resolution electron-microscopy datasets have progressed very rapidly, allowing production annotation of larger, more complete connectomes. More accurate neuronal matching techniques are enriching cell type data with gene expression, neuron activity, behaviour developmental information, providing ways test hypotheses circuit function. In a variety behaviours such as learned innate olfaction, navigation sexual behaviour, connectomics has already revealed interconnected modules hierarchical structure, recurrence integration sensory streams. Comparing individual connectomes determine which features robust variable is one key research area; new work in comparative across development, experience, sex species will establish strong links between connectivity brain

Язык: Английский

Процитировано

43
Olfactory navigation in arthropods DOI Creative Commons

Theresa J. Steele,

Aaron J. Lanz, Katherine I. Nagel

и другие.

Journal of Comparative Physiology A, Год журнала: 2023, Номер 209(4), С. 467 - 488

Опубликована: Янв. 20, 2023

Abstract Using odors to find food and mates is one of the most ancient highly conserved behaviors. Arthropods from flies moths crabs use broadly similar strategies navigate toward odor sources—such as integrating flow information with information, comparing concentration across sensors, over time. Because arthropods share many homologous brain structures—antennal lobes for processing olfactory mechanosensors flow, mushroom bodies (or hemi-ellipsoid bodies) associative learning, central complexes navigation, it likely that these closely related behaviors are mediated by neural circuits. However, differences in types they seek, physics dispersal, locomotion water, air, on substrates mean circuits must have adapted generate a wide diversity odor-seeking In this review, we discuss common specializations observed navigation behavior arthropods, review our current knowledge about subserving behavior. We propose comparative study arthropod nervous systems may provide insight into how set basic circuit structures has diversified different environments.

Язык: Английский

Процитировано

24
Selective integration of diverse taste inputs within a single taste modality DOI Creative Commons

Julia U. Deere,

Arvin A Sarkissian,

Meifeng Yang

и другие.

eLife, Год журнала: 2023, Номер 12

Опубликована: Янв. 24, 2023

A fundamental question in sensory processing is how different channels of input are processed to regulate behavior. Different may converge onto common downstream pathways drive the same behaviors, or they activate separate distinct behaviors. We investigated this Drosophila bitter taste system, which contains diverse bitter-sensing cells residing organs. First, we optogenetically activated subsets neurons within each organ. These elicited broad and highly overlapping behavioral effects, suggesting that pathways, but also observed differences argue for biased convergence. Consistent with these results, transsynaptic tracing revealed organs connect connectivity. one type neuron projects higher brain. integrate from multiple specific taste-related then traced circuits, providing first glimpse into Together, results reveal inputs selectively integrated early circuit, enabling pooling information, while circuit diverges have roles.

Язык: Английский

Процитировано

17
A single pair of pharyngeal neurons functions as a commander to reject high salt in Drosophila melanogaster DOI Creative Commons
Jiun Sang, Subash Dhakal, Bhanu Shrestha

и другие.

eLife, Год журнала: 2023, Номер 12

Опубликована: Дек. 27, 2023

Salt (NaCl), is an essential nutrient for survival, while excessive salt can be detrimental. In the fruit fly, Drosophila melanogaster , internal taste organs in pharynx are critical gatekeepers impacting decision to accept or reject a food. Currently, our understanding of mechanism through which pharyngeal gustatory receptor neurons (GRNs) sense high rudimentary. Here, we found that member ionotropic family, Ir60b expressed exclusively pair GRNs activated by salt. Using two-way choice assay (DrosoX) measure ingestion volume, demonstrate IR60b and two co-receptors IR25a IR76b required prevent consumption. Mutants lacking external but retaining exhibit much higher avoidance than flies with all missing three IRs. Our findings highlight vital role IRs GRN control

Язык: Английский

Процитировано

15
Taste cells expressing Ionotropic Receptor 94e reciprocally impact feeding and egg laying in Drosophila DOI Creative Commons

Jacqueline Guillemin,

Jinfang Li,

Viktoriya Li

и другие.

Cell Reports, Год журнала: 2024, Номер 43(8), С. 114625 - 114625

Опубликована: Авг. 1, 2024

Chemosensory cells across the body of Drosophila melanogaster evaluate environment to prioritize certain behaviors. Previous mapping gustatory receptor neurons (GRNs) on fly labellum identified a set in L-type sensilla that express Ionotropic Receptor 94e (IR94e), but impact IR94e GRNs behavior remains unclear. We used optogenetics and chemogenetics activate found they drive mild feeding suppression enhance egg laying. In vivo calcium imaging revealed respond strongly amino acids, including glutamate, plus co-receptors IR25a IR76b are required for acid detection. Furthermore, mutants show behavioral changes solutions containing increased consumption decreased Overall, our results suggest discourage encourage laying as part an important switch response chemical cues.

Язык: Английский

Процитировано

5
Glia control experience-dependent plasticity in an olfactory critical period DOI Open Access
Hans C. Leier, Alexander J Foden,

Darren A Jindal

и другие.

Опубликована: Янв. 20, 2025

Sensory experience during developmental critical periods has lifelong consequences for circuit function and behavior, but the molecular cellular mechanisms through which causes these changes are not well understood. The Drosophila antennal lobe houses synapses between olfactory sensory neurons (OSNs) downstream projection (PNs) in stereotyped glomeruli. Many glomeruli exhibit structural plasticity response to early-life odor exposure, indicating a general sensitivity of fly circuitry early experience. We recently found that glia shape development young adults, leading us ask if also drive experience-dependent this period. Here we define period functional OSN-PN ethyl butyrate (EB)-sensitive glomerulus VM7. EB exposure first two days post-eclosion drives large-scale reductions glomerular volume, presynapse number, post-synaptic activity. Crucially, pruning long-term since both synapse number spontaneous activity PNs remain persistently decreased following exposure. highly conserved engulfment receptor Draper is required as ensheathing upregulate Draper, invade VM7 glomerulus, phagocytose OSN presynaptic terminals critical-period Loss fully suppresses morphological physiological arguing phagocytic engulf intact synaptic terminals. These data demonstrate argue powerful model defining plasticity.

Язык: Английский

Процитировано

0
Glia control experience-dependent plasticity in an olfactory critical period DOI Creative Commons
Hans C. Leier, Alexander J Foden,

Darren A Jindal

и другие.

eLife, Год журнала: 2025, Номер 13

Опубликована: Янв. 30, 2025

Sensory experience during developmental critical periods has lifelong consequences for circuit function and behavior, but the molecular cellular mechanisms through which causes these changes are not well understood. The Drosophila antennal lobe houses synapses between olfactory sensory neurons (OSNs) downstream projection (PNs) in stereotyped glomeruli. Many glomeruli exhibit structural plasticity response to early-life odor exposure, indicating a general sensitivity of fly circuitry early experience. We recently found that glia shape development young adults, leading us ask if also drive experience-dependent this period. Here, we define period functional OSN-PN ethyl butyrate (EB)-sensitive glomerulus VM7. EB exposure first 2 days post-eclosion drives large-scale reductions glomerular volume, presynapse number, post- synaptic activity. Crucially, pruning long-term since both synapse number spontaneous activity PNs remain persistently decreased following exposure. highly conserved engulfment receptor Draper is required as ensheathing upregulate Draper, invade VM7 glomerulus, phagocytose OSN presynaptic terminals critical-period Loss fully suppresses morphological physiological arguing phagocytic engulf intact terminals. These data demonstrate argue powerful model defining plasticity.

Язык: Английский

Процитировано

0
Extracting spatial information from temporal odor patterns: insights from insects DOI
Paul Szyszka, Thierry Emonet, Timothy L. Edwards

и другие.

Current Opinion in Insect Science, Год журнала: 2023, Номер 59, С. 101082 - 101082

Опубликована: Июль 5, 2023

Язык: Английский

Процитировано

11
NeuroMechFly 2.0, a framework for simulating embodied sensorimotor control in adultDrosophila DOI Creative Commons
Sibo Wang, Victor Alfred Stimpfling,

Thomas Ka Chung Lam

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Сен. 18, 2023

Abstract Discovering principles underlying the control of animal behavior requires a tight dialogue between experiments and neuromechanical models. Until now, such models, including NeuroMechFly for adult fly, Drosophila melanogaster , have primarily been used to investigate motor control. Far less studied with realistic body models is how brain systems work together perform hierarchical sensorimotor Here we present v2, framework that expands modeling by enabling visual olfactory sensing, ascending feedback, complex terrains can be navigated using leg adhesion. We illustrate its capabilities first constructing biologically inspired locomotor controllers use feedback path integration head stabilization. Then, add sensing this controller train it reinforcement learning multimodal navigation task in closed loop. Finally, more biorealistic two ways: our model navigates odor plume taxis strategy, uses connectome-constrained system network follow another simulated fly. With framework, accelerate discovery explanatory nervous develop machine learning-based autonomous artificial agents robots.

Язык: Английский

Процитировано

11