Hypothalamic control of innate social behaviors

Science, Год журнала: 2023, Номер 382(6669), С. 399 - 404

Опубликована: Окт. 26, 2023

Sexual, parental, and aggressive behaviors are central to the reproductive success of individuals species survival thus supported by hardwired neural circuits. The behavior control column (RBCC), which comprises medial preoptic nucleus (MPN), ventrolateral part ventromedial hypothalamus (VMHvl), ventral premammillary (PMv), is essential for all social behaviors. RBCC integrates diverse hormonal metabolic cues adjusts an animal's physical activity, hence chance encounters. further engages mesolimbic dopamine system maintain interest reinforces actions that time-locked with We propose brainstem form a dual-control generating moment-to-moment actions. This Review summarizes recent progress regarding identities cells their pathways drive different aspects

Язык: Английский

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Sexually dimorphic dopaminergic circuits determine sex preference

Science, Год журнала: 2025, Номер 387(6730)

Опубликована: Янв. 9, 2025

Sociosexual preference is critical for reproduction and survival. However, neural mechanisms encoding social decisions on sex remain unclear. In this study, we show that both male female mice exhibit but shift to when facing survival threats; their mediated by the dimorphic changes in excitability of ventral tegmental area dopaminergic (VTA DA ) neurons. males, VTA projections nucleus accumbens (NAc) mediate preference, those medial preoptic preference. females, firing-pattern (phasic-like versus tonic-like) alteration -NAc projection determines sociosexual preferences. These findings define neurons as a key node decision-making reveal sexually circuit underlying

Язык: Английский

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The structural and functional complexity of the integrative hypothalamus

Science, Год журнала: 2023, Номер 382(6669), С. 388 - 394

Опубликована: Окт. 26, 2023

The hypothalamus (“hypo” meaning below, and “thalamus” bed) consists of regulatory circuits that support basic life functions ensure survival. Sitting at the interface between peripheral, environmental, neural inputs, integrates these sensory inputs to influence a range physiologies behaviors. Unlike neocortex, in which stereotyped cytoarchitecture mediates complex across comparatively small number neuronal fates, comprises upwards thousands distinct cell types form redundant yet functionally discrete circuits. With single-cell RNA sequencing studies revealing further cellular heterogeneity modern photonic tools enabling high-resolution dissection circuitry, new era hypothalamic mapping has begun. Here, we provide general overview mammalian organization, development, connectivity help welcome newcomers into this exciting field.

Язык: Английский

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A GnRH neuronal population in the olfactory bulb translates socially relevant odors into reproductive behavior in male mice

Nature Neuroscience, Год журнала: 2024, Номер 27(9), С. 1758 - 1773

Опубликована: Авг. 2, 2024

Язык: Английский

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A time for sex: circadian regulation of mammalian sexual and reproductive function

Frontiers in Neuroscience, Год журнала: 2025, Номер 18

Опубликована: Янв. 6, 2025

The circadian clock regulates physiological and biochemical processes in nearly every species. Sexual reproductive behaviors are two controlled by the timing system. Evidence supporting importance of proper function on fertility comes from several lines work demonstrating that misalignment biological rhythms or disrupted body's master clock, such as occurs repeated shift chronic jet lag, negatively impacts reproduction interfering with both male female fertility. Along these lines, dysregulation genes leads to impairments within mammals, disruption sex hormone levels semen quality males, it ovulatory deficiencies females. Here, we review current understanding modulation hormones-from animal models humans. Further, discuss neural circuits hypothalamus may regulate changes mammalian sexual behavior reproduction, explore how knowledge help improve human function, fertility, reproduction.

Язык: Английский

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Sequential transitions of male sexual behaviors driven by dual acetylcholine-dopamine dynamics

Neuron, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

The neural mechanisms underlying the sequential transitions of male sexual behaviors, including mounting, intromission, and ejaculation, remain largely unexplored. Here, we report that acetylcholine (ACh)-dopamine (DA) dynamics in ventral shell nucleus accumbens (vsNAc) regulate these mice. During vsNAc displays a unique pattern dual ACh-DA rhythms, generated by reciprocal regulation between ACh DA signaling via nicotinic receptors (nAChRs) D2 (D2Rs). Knockdown choline acetyltransferase (ChAT) or D2R diminishes occurrence intromission ejaculation. Optogenetic manipulations demonstrated maintains behaviors suppressing D2RvsNAc neurons. Moreover, promotes initiation mounting facilitates intromission-ejaculation transition inducing slowdown rhythm. Together, findings reveal coordinated play critical role orchestrating behaviors.

Язык: Английский

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Sensory Input, Sex, and Function Shape Hypothalamic Cell Type Development

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Янв. 23, 2024

Abstract Mammalian behavior and physiology undergo dramatic changes in early life. Young animals rely on conspecifics to meet their homeostatic needs, until weaning puberty initiate nutritional independence sex-specific social interactions, respectively. How neuronal populations regulating functions behaviors develop mature during these transitions remains unclear. We used paired transcriptomic chromatin accessibility profiling examine the developmental trajectories of hypothalamic preoptic region, where cell types with key roles physiological behavioral control have been identified 1–6 . These data reveal a remarkable diversity shaped by sex animal, location or function corresponding types. identify stages development, including perinatal emergence differences, postnatal maturation subsequent refinement signaling networks, nonlinear transcriptional accelerating at time puberty. assessed development various sensory mutants find major role for vomeronasal sensing timing type maturation. results provide novel insights into neurons controlling lay ground examining dynamics

Язык: Английский

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Comparative perspectives on neuropeptide function and social isolation

Biological Psychiatry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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Engineering, applications, and future perspectives of GPCR‐based genetically encoded fluorescent indicators for neuromodulators

Journal of Neurochemistry, Год журнала: 2024, Номер 168(3), С. 163 - 184

Опубликована: Янв. 30, 2024

Abstract This review explores the evolving landscape of G‐protein‐coupled receptor (GPCR)‐based genetically encoded fluorescent indicators (GEFIs), with a focus on their development, structural components, engineering strategies, and applications. We highlight unique features this indicator class, emphasizing importance both sensing domain (GPCR structure activation mechanism) reporting (circularly permuted protein (cpFP) fluorescence modulation). Further, we discuss approaches, including selection suitable cpFPs expression systems. Additionally, showcase diversity flexibility application by presenting summary studies where such were used. Along all advantages, also current limitations as well common misconceptions that arise when using these indicators. Finally, future directions in engineering, strategies for screening increased throughput, optimization ligand‐binding properties, insights, spectral diversity. image

Язык: Английский

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Excitation-inhibition imbalance in medial preoptic area circuits underlies chronic stress-induced depression-like states

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Окт. 3, 2024

Язык: Английский

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