
Inflammation Research, Год журнала: 2025, Номер 74(1)
Опубликована: Янв. 13, 2025
Язык: Английский
Inflammation Research, Год журнала: 2025, Номер 74(1)
Опубликована: Янв. 13, 2025
Язык: Английский
Biochemical and Biophysical Research Communications, Год журнала: 2024, Номер 717, С. 149978 - 149978
Опубликована: Апрель 23, 2024
Язык: Английский
Процитировано
10Cell, Год журнала: 2024, Номер unknown
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
10Clinical and Experimental Medicine, Год журнала: 2025, Номер 25(1)
Опубликована: Янв. 3, 2025
Donafenib is an improved version of sorafenib in which deuterium substituted into the drug's chemical structure, enhancing its stability and antitumor activity. exhibits enhanced activity better tolerance than preclinical clinical studies. However, specific mechanism effect on hepatocellular carcinoma has not been reported. Iron deposition a cell death pattern caused by disturbances iron metabolism. Apoptosis form programmed death. They may interact with each other during This study mainly explores potential donafenib activating p53 signaling pathway, inducing deposition, apoptosis carcinoma. Hepa1-6 Huh7 cells were treated various concentrations donafenib. Scratch healing pore migration tests conducted. Analyze through flow cytometry TUNEL fluorescence labeling. RNA sequencing was conducted both untreated donafenib-treated cells. The key proteins involved ferroptosis (SLC7A11, GPX4) (caspase3, caspase8, Bax, Bcl-2, p53) then evaluated using immunoblotting immunohistochemical staining. Reactive oxygen species (ROS) levels cancer measured. treatment resulted dose-dependent decrease proliferation, migration, invasion capabilities There increase rates ROS accumulation, reduction tumor volume. underwent significant changes. activates induce ferroptosis, enhance apoptosis, suggesting as effective therapeutic agent for HCC.
Язык: Английский
Процитировано
2Pathogens, Год журнала: 2025, Номер 14(1), С. 43 - 43
Опубликована: Янв. 8, 2025
PANoptosis is a newly identified programmed cell death pathway that integrates characteristics of apoptosis, pyroptosis, and necroptosis. It plays dual role in the host immune response to bacterial infections. On one hand, acts as protective mechanism by inducing infected cells eliminate pathogens releasing pro-inflammatory cytokines amplify response. other bacteria can exploit evade defenses. This nature underscores potential target for developing novel therapies against review summarizes molecular mechanisms PANoptosis, along with crosstalk integration different pathways various pathogens. We also discuss roles infectious diseases, including sepsis, pulmonary infections, intestinal Elucidating underlying how manipulate this offers critical insights into host-pathogen interactions. These provide foundation designing targeted antibacterial strategies, modulating inflammation, advancing precision medicine improve clinical outcomes.
Язык: Английский
Процитировано
2Inflammation Research, Год журнала: 2025, Номер 74(1)
Опубликована: Янв. 13, 2025
Язык: Английский
Процитировано
2