The protease caspase-1: Activation pathways and functions

Biochemical and Biophysical Research Communications, Год журнала: 2024, Номер 717, С. 149978 - 149978

Опубликована: Апрель 23, 2024

Язык: Английский

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Transplantation of gasdermin pores by extracellular vesicles propagates pyroptosis to bystander cells

Cell, Год журнала: 2024, Номер unknown

Опубликована: Дек. 1, 2024

Язык: Английский

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Donafenib activates the p53 signaling pathway in hepatocellular carcinoma, induces ferroptosis, and enhances cell apoptosis

Clinical and Experimental Medicine, Год журнала: 2025, Номер 25(1)

Опубликована: Янв. 3, 2025

Donafenib is an improved version of sorafenib in which deuterium substituted into the drug's chemical structure, enhancing its stability and antitumor activity. exhibits enhanced activity better tolerance than preclinical clinical studies. However, specific mechanism effect on hepatocellular carcinoma has not been reported. Iron deposition a cell death pattern caused by disturbances iron metabolism. Apoptosis form programmed death. They may interact with each other during This study mainly explores potential donafenib activating p53 signaling pathway, inducing deposition, apoptosis carcinoma. Hepa1-6 Huh7 cells were treated various concentrations donafenib. Scratch healing pore migration tests conducted. Analyze through flow cytometry TUNEL fluorescence labeling. RNA sequencing was conducted both untreated donafenib-treated cells. The key proteins involved ferroptosis (SLC7A11, GPX4) (caspase3, caspase8, Bax, Bcl-2, p53) then evaluated using immunoblotting immunohistochemical staining. Reactive oxygen species (ROS) levels cancer measured. treatment resulted dose-dependent decrease proliferation, migration, invasion capabilities There increase rates ROS accumulation, reduction tumor volume. underwent significant changes. activates induce ferroptosis, enhance apoptosis, suggesting as effective therapeutic agent for HCC.

Язык: Английский

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PANoptosis in Bacterial Infections: A Double-Edged Sword Balancing Host Immunity and Pathogenesis

Pathogens, Год журнала: 2025, Номер 14(1), С. 43 - 43

Опубликована: Янв. 8, 2025

PANoptosis is a newly identified programmed cell death pathway that integrates characteristics of apoptosis, pyroptosis, and necroptosis. It plays dual role in the host immune response to bacterial infections. On one hand, acts as protective mechanism by inducing infected cells eliminate pathogens releasing pro-inflammatory cytokines amplify response. other bacteria can exploit evade defenses. This nature underscores potential target for developing novel therapies against review summarizes molecular mechanisms PANoptosis, along with crosstalk integration different pathways various pathogens. We also discuss roles infectious diseases, including sepsis, pulmonary infections, intestinal Elucidating underlying how manipulate this offers critical insights into host-pathogen interactions. These provide foundation designing targeted antibacterial strategies, modulating inflammation, advancing precision medicine improve clinical outcomes.

Язык: Английский

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Mitochondrial dysfunction is a major cause of thromboinflammation and inflammatory cell death in critical illnesses

Inflammation Research, Год журнала: 2025, Номер 74(1)

Опубликована: Янв. 13, 2025

Язык: Английский

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