Green Extraction of Plant Materials Using Supercritical CO2: Insights into Methods, Analysis, and Bioactivity

Plants, Год журнала: 2024, Номер 13(16), С. 2295 - 2295

Опубликована: Авг. 18, 2024

In recent years, the supercritical CO

Язык: Английский

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A Phenotypic Approach to the Discovery of Potent G-Quadruplex Targeted Drugs

Molecules, Год журнала: 2024, Номер 29(15), С. 3653 - 3653

Опубликована: Авг. 1, 2024

G-quadruplex (G4) sequences, which can fold into higher-order G4 structures, are abundant in the human genome and over-represented promoter regions of many genes involved cancer initiation, progression, metastasis. They plausible targets for G4-binding small molecules, would, case G4s, result transcriptional downregulation these genes. However, structural information is currently available on only a very number G4s their ligand complexes. This limitation, coupled with restricted G4-containing most complex cancers, has led to development phenotypic-led approach drug discovery. was illustrated by discovery several generations tri- tetra-substituted naphthalene diimide (ND) ligands that were found show potent growth inhibition pancreatic cell lines active vivo models this hard-to-treat disease. The cycles have culminated highly ND derivative, QN-302, being evaluated Phase 1 clinical trial. major whose expression been down-regulated QN-302 presented here: all contain propensity be up-regulated cancer. Some also upregulated other supporting hypothesis pan-G4 potential utility beyond

Язык: Английский

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Spatially Resolved Niche and Tumor Microenvironmental Alterations in Gastric Cancer Peritoneal Metastases

Gastroenterology, Год журнала: 2024, Номер 167(7), С. 1384 - 1398.e4

Опубликована: Авг. 13, 2024

Peritoneal metastasis (PM) in gastric cancer (GC) is associated with poor prognosis and significant morbidity. We sought to understand the genomic, transcriptomic, tumor microenvironment (TME) features that contribute peritoneal organotropism GC.

Язык: Английский

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Homeostasis control in health and disease by the unfolded protein response

Nature Reviews Molecular Cell Biology, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 5, 2024

Язык: Английский

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Per- and polyfluoroalkyl substances (PFAS) exposure is associated with radioiodine therapy resistance and dedifferentiation of differentiated thyroid cancer

Environmental Pollution, Год журнала: 2025, Номер 367, С. 125629 - 125629

Опубликована: Янв. 2, 2025

Язык: Английский

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Dual Roles of miR-10a-5p and miR-10b-5p as Tumor Suppressors and Oncogenes in Diverse Cancers

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(1), С. 415 - 415

Опубликована: Янв. 6, 2025

Cancer is a complex genetic disorder characterized by abnormalities in both coding and regulatory non-coding RNAs. microRNAs (miRNAs) are key RNAs that modulate cancer development, functioning as tumor suppressors oncogenes. miRNAs play critical roles progression, influencing processes such initiation, promotion, metastasis. They exert their effects targeting suppressor genes, thereby facilitating while also inhibiting oncogenes to prevent further disease advancement. The miR-10 family, particularly miR-10a-5p miR-10b-5p (miR-10a/b-5p), notably involved progression. Intriguingly, functions can differ across different cancers, sometimes promoting at other times suppressing growth depending on the type target genes. This review explores dual of miR-10a/b-5p tumor-suppressive (TSmiRs) or oncogenic (oncomiRs) various cancers examining molecular cellular mechanisms impact microenvironment. Furthermore, we discuss potential therapeutic targets, emphasizing miRNA-based strategies for treatment. insights discussed this aim advance our understanding miR-10a/b-5p’s biology application developing innovative therapies.

Язык: Английский

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Oncohistone-sculpted Epigenetic Mechanisms in Pediatric Brain Cancer

Current Opinion in Pharmacology, Год журнала: 2025, Номер 81, С. 102505 - 102505

Опубликована: Янв. 9, 2025

Язык: Английский

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Therapeutic Black Phosphorus Nanosheets Elicit Neutrophil Response for Enhanced Tumor Suppression

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Янв. 22, 2025

Abstract Black phosphorus (BP) has demonstrated potential as a drug carrier and photothermal agent in cancer therapy; however, its intrinsic functions treatment remain underexplored. This study investigates the immunomodulatory effects of polyethylene glycol‐functionalized BP (BP‐PEG) nanosheets breast models. Using immunocompetent mouse models‐including 4T1 orthotopic BALB/c mice MMTV‐PyMT transgenic mice, it is found that BP‐PEG significantly inhibits tumor growth metastasis without directly inducing cytotoxicity cells. Mass cytometry analysis reveals reshapes immune microenvironment by recruiting neutrophils. Neutrophil depletion experiments further demonstrate antitumor are dependent on Moreover, bulk single‐cell RNA sequencing indicate mainly taken up macrophages, leading to release inflammatory factors such IL1A CXCL2, which enhance neutrophil recruitment activation, thereby amplifying response. Finally, co‐culture assays confirm indeed enhances activity neutrophils natural killer (NK) These findings position an capable reprogramming promote innate immunity against cancer. By stimulating neutrophil‐mediated activity, offers unique therapeutic approach can potentially efficacy existing immunotherapies.

Язык: Английский

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Role of Fungi in Tumorigenesis: Promises and Challenges

Annual Review of Pathology Mechanisms of Disease, Год журнала: 2025, Номер 20(1), С. 459 - 482

Опубликована: Янв. 24, 2025

The mycobiome plays a key role in the host immune responses homeostasis and inflammation. Recent studies suggest that an imbalance gut's fungi contributes to chronic, noninfectious diseases such as obesity, metabolic disorders, cancers. Pathogenic can colonize specific organs, gut has been linked development progression of various cancers, including colorectal, breast, head neck, pancreatic Some fungal species promote tumorigenesis by triggering complement system. However, immunocompromised patients, also inhibit this activation establish life-threatening infections. Interestingly, interaction bacteria induce unique responses. breakthroughs advancements high-throughput sequencing tumor mycobiomes are highlighting novel diagnostic therapeutic opportunities for cancer. We discuss latest developments field cancer potential benefits challenges antifungal therapies.

Язык: Английский

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Non‐Enzymatic Destruction of the Extracellular Matrix for Activatable Orthotopic Tumor Treatment and Enhanced Drug Penetration

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 28, 2025

Abstract The controlled release and enhanced penetration of drugs to deep‐seated tumors is highly desirable but faces many challenges. Herein, supramolecular biomimetic nanoaggregates (HFCu NAs) are constructed with fluorinated histidine copper ions via multivalent interactions (metal coordination aromatic packing), affording tumor microenvironment responsive “turn‐on” 19 F magnetic resonance imaging （ MRI） guided drug delivery specific therapy. By virtue ligand engineering pH‐triggered conformation changes, HFCu NAs exhibit reactive oxygen species （ROS）generation due lower pH levels at sites, leading the stepwise collapse extracellular matrix (ECM), which analogous targeted protein degradation, without requiring endogenous enzymes. Consequently, breakdown ECM provides positive feedback for permeation NAs, thereby, significantly inhibiting orthotopic growth explicit immunogenic cell death. As such, proposed platform exhibits significant potential as activatable vehicles

Язык: Английский

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