Nature and Science of Sleep,
Год журнала:
2024,
Номер
Volume 16, С. 2045 - 2061
Опубликована: Дек. 1, 2024
Sleep
apnea
(SA),
associated
with
absent
neural
output,
is
characterised
by
recurrent
episodes
of
hypoxemia
and
repeated
arousals
during
sleep,
resulting
in
decreased
sleep
quality
various
health
complications.
Mitochondrial
DNA
copy
number
(mtDNA-CN),
an
easily
accessible
biomarker
blood,
reflects
mitochondrial
function.
However,
the
causal
relationship
between
mtDNA-CN
SA
remains
unclear.
This
study
aimed
to
investigate
causality
while
identifying
potential
mediating
brain
imaging
phenotypes
(BIPs).
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 26, 2025
The
risk
of
diabetic
cardiovascular
complications
is
closely
linked
to
the
length
hyperglycemia
exposure.
Mitophagy
plays
a
significant
role
in
vascular
endothelial
injury.
However,
specific
mechanisms
by
which
mitophagy
contributes
injury
during
sustained
remain
unclear.
In
ApoE-/-
mice
and
human
umbilical
vein
cell
(HUVEC)
models,
enhanced
following
short-term
long-term
high-glucose
Short-term
exposure
promotes
Parkin-mediated
upregulates
mitochondrial
fission
protein
1
(Fis1)
expression,
whereas
suppresses
downregulates
Fis1.
With
prolonged
exposure,
Syntaxin
17
(STX17)
translocates
from
endoplasmic
reticulum
mitochondria,
activating
STX17-mediated
mitophagy.
Silencing
STX17
alleviates
degradation,
decreases
reactive
oxygen
species
(ROS)
levels,
enhances
nitric
oxide
synthase
(eNOS)
phosphorylation,
reduces
apoptosis.
Fis1
accelerates
switching
mitophagy,
worsening
dysfunction,
overexpression
prevents
this
switching,
reducing
ROS
apoptosis
enhancing
eNOS
phosphorylation.
summary,
these
findings
suggest
that
drives
hyperglycemic
providing
valuable
insights
into
therapeutic
strategies
for
complications.
