Polystyrene nanoplastics induce lipophagy via the AMPK/ULK1 pathway and block lipophagic flux leading to lipid accumulation in hepatocytes
Journal of Hazardous Materials,
Год журнала:
2024,
Номер
476, С. 134878 - 134878
Опубликована: Июнь 12, 2024
Язык: Английский
Quercetin ameliorates oxidative stress-induced apoptosis of granulosa cells in dairy cow follicular cysts by activating autophagy via the SIRT1/ROS/AMPK signaling pathway
Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology,
Год журнала:
2024,
Номер
15(1)
Опубликована: Сен. 5, 2024
Язык: Английский
The Interplay between Salmonella and Host: Mechanisms and Strategies for Bacterial Survival
Cell Insight,
Год журнала:
2025,
Номер
4(2), С. 100237 - 100237
Опубликована: Фев. 13, 2025
Salmonella,
an
intracellular
pathogen,
infects
both
humans
and
animals,
causing
diverse
diseases
such
as
gastroenteritis
enteric
fever.
The
Salmonella
type
III
secretion
system
(T3SS),
encoded
within
its
pathogenicity
islands
(SPIs),
is
critical
for
bacterial
virulence
by
directly
delivering
multiple
effectors
into
eukaryotic
host
cells.
utilizes
these
to
facilitate
survival
replication
the
through
modulating
cytoskeletal
dynamics,
inflammatory
responses,
biogenesis
of
Salmonella-containing
vacuole
(SCV),
cell
survival.
Moreover,
also
interfere
with
immune
responses
via
inhibiting
innate
immunity
or
antigen
presentation.
In
this
review,
we
summarize
current
progress
in
strategies
employed
molecular
mechanisms
underlying
interactions
host.
Understanding
interplay
between
can
enhance
our
knowledge
bacterium's
pathogenic
processes
provide
new
insights
how
it
manipulates
cellular
physiological
activities
ensure
Язык: Английский
Hypomyelination Leukodystrophy 16 (HLD16)-Associated Mutation p.Asp252Asn of TMEM106B Blunts Cell Morphological Differentiation
Current Issues in Molecular Biology,
Год журнала:
2024,
Номер
46(8), С. 8088 - 8103
Опубликована: Июль 27, 2024
Transmembrane
protein
106B
(TMEM106B),
which
is
a
type
II
transmembrane
protein,
believed
to
be
involved
in
intracellular
dynamics
and
morphogenesis
the
lysosome.
TMEM106B
known
risk
factor
for
frontotemporal
lobar
degeneration
has
been
recently
identified
as
receptor
needed
entry
of
SARS-CoV-2,
independently
angiotensin-converting
enzyme
2
(ACE2).
A
missense
mutation,
p.Asp252Asn,
associated
with
hypomyelinating
leukodystrophy
16
(HLD16),
an
oligodendroglial
cell-related
white
matter
disorder
causing
thin
myelin
sheaths
or
deficiency
central
nervous
system
(CNS).
However,
it
remains
elucidated
how
mutated
affects
cells.
Here,
we
show
that
mutant
fails
exhibit
lysosome
distribution
FBD-102b
cell
line,
precursor
line
undergoing
differentiation.
In
contrast,
wild-type
was
indeed
localized
Cells
harboring
differentiated
into
ones
widespread
membranes,
whereas
cells
failed
differentiate.
It
note
output
signaling
through
lysosome-resident
mechanistic
target
rapamycin
(mTOR)
greatly
decreased
TMEM106B.
Furthermore,
treatment
hesperetin,
citrus
flavonoid
activator
mTOR
signaling,
restored
molecular
cellular
phenotypes
induced
by
protein.
These
findings
suggest
potential
pathological
mechanisms
underlying
HLD16
their
amelioration.
Язык: Английский
Autophagy and its role in gastrointestinal diseases
World Journal of Gastroenterology,
Год журнала:
2024,
Номер
30(36), С. 4014 - 4020
Опубликована: Сен. 20, 2024
Gastrointestinal
disorders
encompass
a
spectrum
of
conditions
affecting
various
organs
within
the
digestive
system,
such
as
esophagus,
stomach,
colon,
rectum,
pancreas,
liver,
small
intestine,
and
bile
ducts.
The
role
autophagy
in
etiology
progression
gastrointestinal
diseases
has
garnered
significant
attention.
This
paper
seeks
to
evaluate
impact
mechanisms
by
synthesizing
recent
research
findings.
Specifically,
we
delve
into
inflammation-related
conditions,
including
ul-cerative
colitis,
Crohn’s
disease,
pancreatitis,
well
cancers
esophageal,
gastric,
colorectal
cancers.
Additionally,
provide
commentary
on
publication
Chang
et
al
World
Journal
Gastroenterology
.
Our
objective
is
offer
fresh
perspectives
therapeutic
approaches
for
these
ailments.
review
aims
new
strategies
critically
analyzing
relevant
publications.
As
discussed,
complex
and,
at
times,
contentious.
To
harness
full
potential
treating
more
in-depth
imperative.
Язык: Английский
Functional Role of Hepatitis C Virus NS5A in the Regulation of Autophagy
Pathogens,
Год журнала:
2024,
Номер
13(11), С. 980 - 980
Опубликована: Ноя. 8, 2024
Many
types
of
RNA
viruses,
including
the
hepatitis
C
virus
(HCV),
activate
autophagy
in
infected
cells
to
promote
viral
growth
and
counteract
host
defense
response.
Autophagy
acts
as
a
catabolic
pathway
which
unnecessary
materials
are
removed
via
lysosome,
thus
maintaining
cellular
homeostasis.
The
HCV
non-structural
5A
(NS5A)
protein
is
phosphoprotein
required
for
replication,
virion
assembly,
determination
interferon
(IFN)
sensitivity.
Recently,
increasing
evidence
has
shown
that
NS5A
can
induce
mitochondrial
turnover
degradation
hepatocyte
nuclear
factor
1
alpha
(HNF-1α)
diacylglycerol
acyltransferase
(DGAT1).
In
this
review,
we
summarize
recent
progress
understanding
detailed
mechanism
by
triggers
autophagy,
outline
physiological
significance
balance
between
host-virus
interactions.
Язык: Английский
Hepatitis C Virus NS5A Activates Mitophagy Through Cargo Receptor and Phagophore Formation
Pathogens,
Год журнала:
2024,
Номер
13(12), С. 1139 - 1139
Опубликована: Дек. 23, 2024
Chronic
HCV
infection
is
a
risk
factor
for
end-stage
liver
disease,
leading
to
major
burden
on
public
health.
Mitophagy
specific
form
of
selective
autophagy
that
eliminates
mitochondria
maintain
mitochondrial
integrity.
NS5A
multifunctional
protein
regulates
the
life
cycle
and
may
induce
host
mitophagy.
However,
molecular
mechanism
by
which
activates
mitophagy
remains
largely
unknown.
Here,
first
time,
we
delineate
dynamic
process
NS5A-activated
PINK1/Parkin-dependent
By
performing
live-cell
imaging
CLEM
analyses
NS5A-expressing
cells,
demonstrate
degradation
within
autophagic
vacuoles,
dependent
Parkin
ubiquitin
translocation
onto
PINK1
stabilization.
In
addition,
cargo
receptors
mitophagy,
NDP52
OPTN,
are
recruited
required
NS5A-induced
Moreover,
ATG5
DFCP1,
function
in
autophagosome
closure
phagophore
formation,
translocated
near
Furthermore,
autophagy-initiating
proteins,
including
ATG14
ULK1,
NS5A-triggered
Together,
these
findings
through
recognition
nascent
formation
phagophores
close
mitochondria.
Язык: Английский