Coptisine enhances the sensitivity of chemoresistant breast cancer cells by inhibiting the function and expression of ABC transporters DOI Creative Commons
Safaa Yehia Eid

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Дек. 3, 2024

Multidrug resistance (MDR), mainly caused by ATP-binding cassette transporters (ABCTs) efflux, makes it difficult for many anticancer drugs to treat breast cancer (BC). Phytochemicals can reverse cancer's MDR modifying ABC transporter expression and function, as well working synergistically with target other molecules. The reversal effect of the isoquinoline alkaloid coptisine (COP) was assessed on four cell lines; Two sensitive MCF-7 lines positive estrogen, androgen, progesterone, glucocorticoid receptors, MDB-MB-231 cells negative HER2 two doxorubicin-resistant lines, MCF-7/ADR MDB-MB-231/ADR.

Язык: Английский

Brassinin from Brassica campestris L. inhibits colorectal cancer by inducing p62/NRF2/GPX4‐regulated ferroptosis DOI Creative Commons
Shiyuan Wen,

Rifeng Gao,

Yanyan Chen

и другие.

Animal Models and Experimental Medicine, Год журнала: 2025, Номер unknown

Опубликована: Янв. 23, 2025

Abstract Background Indole phytoalexins, plant‐derived compounds present in cruciferous vegetables, have demonstrated anticancer properties. Brassinin (BSN), derived from Brassica campestris L. var. campestris, is known for its potent antitumor effects on various cancers. However, the role of ferroptosis regulating BSN has not been fully elucidated. Methods The components B. against colorectal cancer (CRC) were analyzed by network pharmacology. CCK‐8 assay and colony formation detected cell viability induced BSN. Molecular docking verified binding to target protein. Western blot reverse transcription–quantitative polymerase chain reaction (RT‐qPCR) revealed whether can inactivate NRF2 signaling inhibit expression p62 HO‐1. RKO‐xenograft tumor models established then treated 75 or 150 mg/kg verify efficacy side Results Network pharmacology suggested that most important component CRC. inhibits CRC a dose‐ time‐dependent manner. Furthermore, this inhibitory effect associated with induction ferroptosis, as suppresses inducing GPX4‐regulated ferroptosis. may bind protein signaling, inhibiting Importantly, low dose high significantly reduced growth vivo. Conclusions Our findings reveal blocks p62/NRF2/GPX4‐regulated which be novel lead compound treatment.

Язык: Английский

Процитировано

1
Exosomal microRNA as a key regulator of PI3K/AKT pathways in human tumors DOI
Saade Abdalkareem Jasim, Abdulrahman T. Ahmed,

Aziz Kubaev

и другие.

Medical Oncology, Год журнала: 2024, Номер 41(11)

Опубликована: Окт. 14, 2024

Язык: Английский

Процитировано

3
Coptisine enhances the sensitivity of chemoresistant breast cancer cells by inhibiting the function and expression of ABC transporters DOI Creative Commons
Safaa Yehia Eid

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Дек. 3, 2024

Multidrug resistance (MDR), mainly caused by ATP-binding cassette transporters (ABCTs) efflux, makes it difficult for many anticancer drugs to treat breast cancer (BC). Phytochemicals can reverse cancer's MDR modifying ABC transporter expression and function, as well working synergistically with target other molecules. The reversal effect of the isoquinoline alkaloid coptisine (COP) was assessed on four cell lines; Two sensitive MCF-7 lines positive estrogen, androgen, progesterone, glucocorticoid receptors, MDB-MB-231 cells negative HER2 two doxorubicin-resistant lines, MCF-7/ADR MDB-MB-231/ADR.

Язык: Английский

Процитировано

2