The Role and Mechanism of Innate Immune Regulation in Overcoming Oxaliplatin Resistance and Enhancing Anti-Tumor Efficacy in Colorectal Cancer
Pharmaceuticals,
Год журнала:
2025,
Номер
18(3), С. 317 - 317
Опубликована: Фев. 24, 2025
Background/Objectives:
The
reversal
effect
of
cGAMP,
as
a
STING
pathway
regulator,
on
oxaliplatin
resistance
in
colorectal
cancer
was
investigated,
and
its
mechanism
proposed.
Methods:
efficacy
the
cGAMP
combination
for
oxaliplatin-resistant
through
nude
mouse
tumor
model
were
investigated
analyzed,
western
blot
analysis
tumors
applied.
Results:
After
OXA
treatment,
IC50
values
HCT116
HCT116/L
cells
9.04
μmol/L
47.04
μmol/L,
respectively.
In
models,
significantly
reversed
to
primary
drug-resistant
cancer,
inhibition
rate
increased
from
8%
(oxaliplatin
alone)
60%
(combination).
transplanted
model,
combined
treatment
also
showed
more
significant
than
alone,
by
39%,
indicating
that
had
considerable
improvement
acquired
resistance.
These
results
fully
demonstrated
synergistic
oxaliplatin.
Western
enhanced
sensitivity
down-regulating
expression
p-PI3K
p-AKT
up-regulating
p53
protein.
Conclusions:
an
immunomodulator
against
resistance,
shows
potential
application
prospect
treating
cancer.
Язык: Английский
Advances in Nanoparticles in Targeted Drug Delivery- A Review
Results in Surfaces and Interfaces,
Год журнала:
2025,
Номер
unknown, С. 100529 - 100529
Опубликована: Апрель 1, 2025
Язык: Английский
Cell-Autonomous Immunity: From Cytosolic Sensing to Self-Defense
Danlin Han,
Bozheng Zhang,
Zhe Wang
и другие.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(9), С. 4025 - 4025
Опубликована: Апрель 24, 2025
As
an
evolutionarily
conserved
and
ubiquitous
mechanism
of
host
defense,
non-immune
cells
in
vertebrates
possess
the
intrinsic
ability
to
autonomously
detect
combat
intracellular
pathogens.
This
process,
termed
cell-autonomous
immunity,
is
distinct
from
classical
innate
immunity.
In
this
review,
we
comprehensively
examine
defense
mechanisms
employed
by
response
pathogen
invasion.
We
provide
a
detailed
analysis
cytosolic
sensors
that
recognize
aberrant
nucleic
acids,
lipopolysaccharide
(LPS),
other
pathogen-associated
molecular
patterns
(PAMPs).
Specifically,
elucidate
underlying
key
signaling
pathways,
including
cyclic
GMP-AMP
synthase
(cGAS)-stimulator
interferon
genes
(STING)
pathway,
retinoic
acid-inducible
gene
I
(RIG-I)-like
receptors
(RLRs)-mitochondrial
antiviral
(MAVS)
axis,
guanylate-binding
proteins
(GBPs)-mediated
pathway.
Furthermore,
critically
evaluate
involvement
these
pathways
pathogenesis
various
diseases,
autoimmune
disorders,
inflammatory
conditions,
malignancies,
while
highlighting
their
potential
as
therapeutic
targets.
Язык: Английский