The Role and Mechanism of Innate Immune Regulation in Overcoming Oxaliplatin Resistance and Enhancing Anti-Tumor Efficacy in Colorectal Cancer

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(3), P. 317 - 317

Published: Feb. 24, 2025

Background/Objectives: The reversal effect of cGAMP, as a STING pathway regulator, on oxaliplatin resistance in colorectal cancer was investigated, and its mechanism proposed. Methods: efficacy the cGAMP combination for oxaliplatin-resistant through nude mouse tumor model were investigated analyzed, western blot analysis tumors applied. Results: After OXA treatment, IC50 values HCT116 HCT116/L cells 9.04 μmol/L 47.04 μmol/L, respectively. In models, significantly reversed to primary drug-resistant cancer, inhibition rate increased from 8% (oxaliplatin alone) 60% (combination). transplanted model, combined treatment also showed more significant than alone, by 39%, indicating that had considerable improvement acquired resistance. These results fully demonstrated synergistic oxaliplatin. Western enhanced sensitivity down-regulating expression p-PI3K p-AKT up-regulating p53 protein. Conclusions: an immunomodulator against resistance, shows potential application prospect treating cancer.

Language: Английский

Advances in Nanoparticles in Targeted Drug Delivery- A Review

Results in Surfaces and Interfaces, Journal Year: 2025, Volume and Issue: unknown, P. 100529 - 100529

Published: April 1, 2025

Language: Английский

Cell-Autonomous Immunity: From Cytosolic Sensing to Self-Defense

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 4025 - 4025

Published: April 24, 2025

As an evolutionarily conserved and ubiquitous mechanism of host defense, non-immune cells in vertebrates possess the intrinsic ability to autonomously detect combat intracellular pathogens. This process, termed cell-autonomous immunity, is distinct from classical innate immunity. In this review, we comprehensively examine defense mechanisms employed by response pathogen invasion. We provide a detailed analysis cytosolic sensors that recognize aberrant nucleic acids, lipopolysaccharide (LPS), other pathogen-associated molecular patterns (PAMPs). Specifically, elucidate underlying key signaling pathways, including cyclic GMP-AMP synthase (cGAS)-stimulator interferon genes (STING) pathway, retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs)-mitochondrial antiviral (MAVS) axis, guanylate-binding proteins (GBPs)-mediated pathway. Furthermore, critically evaluate involvement these pathways pathogenesis various diseases, autoimmune disorders, inflammatory conditions, malignancies, while highlighting their potential as therapeutic targets.

Language: Английский