Captivity humanizes the primate microbiome

Proceedings of the National Academy of Sciences, Год журнала: 2016, Номер 113(37), С. 10376 - 10381

Опубликована: Авг. 29, 2016

Significance Trillions of bacteria live in the primate gut, contributing to metabolism, immune system development, and pathogen resistance. Perturbations these are associated with metabolic autoimmune human diseases that prevalent Westernized societies. Herein, we measured gut microbial communities diet multiple species living wild, a sanctuary, full captivity. We found captivity loss dietary fiber nonhuman primates native microbiota convergence toward modern microbiome, suggesting parallel processes may be driving recent core biodiversity humans.

Язык: Английский

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Prevotella in the gut: choose carefully

Nature Reviews Gastroenterology & Hepatology, Год журнала: 2016, Номер 13(2), С. 69 - 70

Опубликована: Фев. 1, 2016

Язык: Английский

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Dietary Fibre Modulates the Gut Microbiota

Nutrients, Год журнала: 2021, Номер 13(5), С. 1655 - 1655

Опубликована: Май 13, 2021

Dietary fibre has long been established as a nutritionally important, health-promoting food ingredient. Modern dietary practices have seen significant reduction in consumption compared with ancestral habits. This is related to the emergence of low-fibre “Western diets” associated industrialised nations, and linked an increased prevalence gut diseases such inflammatory bowel disease, obesity, type II diabetes mellitus metabolic syndrome. The characteristic parameters these individuals include insulin resistance, high fasting postprandial glucose, well plasma cholesterol, low-density lipoprotein (LDL) high-density (HDL). Gut microbial signatures are also altered significantly cohorts, suggesting causative link between diet, microbes disease. hypothesised reverse changes through fermentation subsequent production short-chain fatty acids (SCFA), which improves glucose lipid who harbour dysfunctional metabolism. review article examines how different types can differentially alter metabolism microbiota composition function.

Язык: Английский

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The gut microbiome of healthy Japanese and its microbial and functional uniqueness

DNA Research, Год журнала: 2016, Номер 23(2), С. 125 - 133

Опубликована: Март 6, 2016

The human gut microbiome has profound influences on the host's health largely through its interference with various intestinal functions. As recent studies have suggested diversity in among populations, it will be interesting to analyse how is correlated geographical, cultural, and traditional differences. Japanese people are known several characteristic features such as eating a variety of foods exhibiting low BMI long life span. In this study, we analysed microbiomes by comparing metagenomic data obtained from 106 individuals those 11 other nations. We found that composition showed more abundant phylum Actinobacteria, particular genus Bifidobacterium, than Regarding microbial functions, carbohydrate metabolism were overrepresented concurrent decrease for replication repair, cell motility. remarkable prevalence genes methanogenesis significant depletion archaeon Methanobrevibacter smithii enrichment acetogenesis compared others difference hydrogen pathway between them. It thus seems considerably different which cannot simply explained diet alone. postulate possible existence hitherto unknown factors contributing population-level microbiomes.

Язык: Английский

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The gut microbiota in human energy homeostasis and obesity

Trends in Endocrinology and Metabolism, Год журнала: 2015, Номер 26(9), С. 493 - 501

Опубликована: Авг. 8, 2015

Язык: Английский

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