Increased Prevalence of Calcium Transients across the Dendritic Arbor during Place Field Formation

Neuron, Год журнала: 2017, Номер 96(2), С. 490 - 504.e5

Опубликована: Окт. 1, 2017

Язык: Английский

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Neuromodulation of Spike-Timing-Dependent Plasticity: Past, Present, and Future

Neuron, Год журнала: 2019, Номер 103(4), С. 563 - 581

Опубликована: Авг. 1, 2019

Язык: Английский

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Specific Basal Forebrain–Cortical Cholinergic Circuits Coordinate Cognitive Operations

Journal of Neuroscience, Год журнала: 2018, Номер 38(44), С. 9446 - 9458

Опубликована: Окт. 31, 2018

Based on recent molecular genetics, as well functional and quantitative anatomical studies, the basal forebrain (BF) cholinergic projections, once viewed a diffuse system, are emerging being remarkably specific in connectivity. Acetylcholine (ACh) can rapidly selectively modulate activity of circuits ACh release be coordinated multiple areas that related to particular aspects cognitive processing. This review discusses how combination new approaches with more established techniques used finally reveal neurons, together other BF provide temporal structure for behavior, contribute local cortical state regulation, coordinate between different functionally circuits. modulates dynamics encoding attention within individual circuits, allows important transitions during sleep, shapes fidelity sensory processing by changing correlation neural firing. The importance this system integrated fluid behavioral function is underscored its disease-modifying role; demise neurons has long been Alzheimer's disease studies have revealed involvement modulation anxiety-related Therefore, plays pivotal role modulating brain sleep foretold intricacies map.

Язык: Английский

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Sleep and synaptic down‐selection

European Journal of Neuroscience, Год журнала: 2019, Номер 51(1), С. 413 - 421

Опубликована: Янв. 7, 2019

Abstract The synaptic homeostasis hypothesis (SHY) proposes that sleep is an essential process needed by the brain to maintain total amount of strength under control. SHY predicts end a waking day connections many neural circuits undergo net increase in due ongoing learning, which mainly mediated potentiation. Stronger synapses require more energy and supplies are prone saturation, creating need for renormalization. Such renormalization should occur during sleep, when disconnected from environment can be broadly reactivated off‐line systematic but specific down‐selection. In short, according price pay plasticity, avoid runaway potentiation, decreased signal‐to‐noise ratio, impaired learning saturation. this review, we briefly discuss rationale recent supportive ultrastructural evidence obtained our laboratory. We then examine studies other groups showing causal role cortical slow waves hippocampal sharp waves/ripples sleep‐dependent down‐selection activity strength. Finally, some molecular mechanisms could mediate weakening sleep.

Язык: Английский

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Basal forebrain cholinergic signalling: development, connectivity and roles in cognition

Nature reviews. Neuroscience, Год журнала: 2023, Номер 24(4), С. 233 - 251

Опубликована: Фев. 23, 2023

Язык: Английский

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Cholinergic and noradrenergic axonal activity contains a behavioral-state signal that is coordinated across the dorsal cortex

eLife, Год журнала: 2023, Номер 12

Опубликована: Апрель 27, 2023

Fluctuations in brain and behavioral state are supported by broadly projecting neuromodulatory systems. In this study, we use mesoscale two-photon calcium imaging to examine spontaneous activity of cholinergic noradrenergic axons awake mice order determine the interaction between arousal/movement transitions across dorsal cortex at distances separated up 4 mm. We confirm that GCaMP6s within axonal projections both basal forebrain locus coeruleus neurons track arousal, indexed as pupil diameter, changes engagement, reflected bouts whisker movement and/or locomotion. The broad coordination even distant segments indicates these systems can communicate, part, through a global signal, especially relation state. addition coordinated activity, also find evidence subpopulation may exhibit heterogeneity appears be independent our measures By monitoring interneurons cortex, found cells state-dependent (arousal/movement) activity. These results demonstrate provide prominent synchronized signal related state, therefore contribute cortical excitability.

Язык: Английский

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Reward-Based Learning Drives Rapid Sensory Signals in Medial Prefrontal Cortex and Dorsal Hippocampus Necessary for Goal-Directed Behavior

Neuron, Год журнала: 2017, Номер 97(1), С. 83 - 91.e5

Опубликована: Дек. 14, 2017

The neural circuits underlying learning and execution of goal-directed behaviors remain to be determined. Here, through electrophysiological recordings, we investigated fast sensory processing across multiple cortical areas as mice learned lick a reward spout in response brief deflection single whisker. Sensory-evoked signals were absent from medial prefrontal cortex dorsal hippocampus naive mice, but developed with task correlated behavioral performance trained the detection task. responses occurred short latencies less than 50 ms after whisker deflection. Pharmacological optogenetic inactivation or impaired performance. Neuronal activity thus appears contribute directly performance, perhaps providing top-down control learned, context-dependent transformation input into motor output.

Язык: Английский

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Neuromodulation of hippocampal long-term synaptic plasticity

Current Opinion in Neurobiology, Год журнала: 2018, Номер 54, С. 37 - 43

Опубликована: Сен. 10, 2018

Multiple neuromodulators including acetylcholine, noradrenaline, dopamine and serotonin are released in response to uncertainty focus attention on events where the predicted outcome does not match observed reality. In these situations, internal representations need be updated, a process that requires long-term synaptic plasticity. Through variety of common divergent mechanisms, it is recently shown all facilitate induction and/or expression plasticity within hippocampus. Under physiological conditions, this may critical for suprathreshold endowing with gating function providing mechanism by which enable targeted updating memory relevant information improve accuracy future predictions.

Язык: Английский

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Co-transmission of acetylcholine and GABA regulates hippocampal states

Nature Communications, Год журнала: 2018, Номер 9(1)

Опубликована: Июль 16, 2018

The basal forebrain cholinergic system is widely assumed to control cortical functions via non-synaptic transmission of a single neurotransmitter. Yet, we find that mouse hippocampal terminals invariably establish GABAergic synapses, and their vesicles dock at those synapses only. We demonstrate these do not co-release but co-transmit GABA acetylcholine different vesicles, whose release triggered by distinct calcium channels. This co-transmission evokes composite postsynaptic potentials, which are mutually cross-regulated presynaptic autoreceptors. Although receptor distribution cannot be investigated, response latencies suggest focal, intra- and/or peri-synaptic localisation, while GABAA receptors detected intra-synaptically. component alone effectively suppresses sharp wave-ripples epileptiform activity. Therefore, the differentially regulated suggests hitherto unrecognised level over states. novel model neurotransmission may lead alternative pharmacotherapies after deinnervation seen in neurodegenerative disorders.

Язык: Английский

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Frontiers in electrochemical sensors for neurotransmitter detection: towards measuring neurotransmitters as chemical diagnostics for brain disorders

Analytical Methods, Год журнала: 2019, Номер 11(21), С. 2738 - 2755

Опубликована: Янв. 1, 2019

It is extremely challenging to chemically diagnose disorders of the brain. There hence great interest in designing and optimizing tools for direct detection chemical biomarkers implicated neurological improve diagnosis treatment. Tools that are capable monitoring brain chemicals, neurotransmitters particular, need be biocompatible, perform with high spatiotemporal resolution, ensure selectivity sensitivity. Recent advances electrochemical methods addressing these criteria; resulting devices demonstrate promise vivo neurotransmitter detection. None currently used diagnostic purposes, however cutting-edge technologies promising more sensitive, selective, faster, less invasive measurements. Via this review we highlight significant technical studies, performed last 5 years, believe will facilitate development disorders.

Язык: Английский

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