Neuromodulation of Attention

Neuron, Год журнала: 2018, Номер 97(4), С. 769 - 785

Опубликована: Фев. 1, 2018

Attention is critical to high-level cognition and attention deficits are a hallmark of neurologic neuropsychiatric disorders. Although years research indicates that distinct neuromodulators influence attentional control, mechanistic account traverses levels analysis (cells, circuits, behavior) missing. However, such an guide the development next-generation pharmacotherapies aimed at forestalling or remediating global burden associated with disorders attention. Here, we summarize current neuroscientific understanding how affects single neurons networks neurons. We then review key results have informed our neuromodulation shapes these neuron network properties thereby enables appropriate allocation relevant external internal events. Finally, highlight areas where believe hypotheses can be formulated tackled experimentally in near future, critically increasing implemented cellular levels. 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Язык: Английский

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Generation of a whole-brain atlas for the cholinergic system and mesoscopic projectome analysis of basal forebrain cholinergic neurons

Proceedings of the National Academy of Sciences, Год журнала: 2017, Номер 115(2), С. 415 - 420

Опубликована: Дек. 19, 2017

Significance The cholinergic system plays a critical role in neural modulation of the mammalian brain. Here, we generated comprehensive atlas mouse brain via whole-brain imaging and reconstruction system. In dataset, neurons were divided into three categories including cortical VIP neurons, long-range projection brainstem motor neurons. After reconstructing subregion basal forebrain, found that their projections to forebrain midbrain showed neuronal subgroups with distinct specificity. Our work presents three-dimensional information about brain, facilitating further studies

Язык: Английский

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The Brain from Inside Out

Oxford University Press eBooks, Год журнала: 2019, Номер unknown

Опубликована: Июнь 17, 2019

Abstract The Brain from Inside Out takes a critical look at contemporary brain research and reminds us that theoretical framework does matter. Current technology-driven neuroscience is still largely fueled by an empiricist philosophy assuming the brain’s goal to perceive, represent world, learn truth. An inevitable consequence of this assumption decision-making homunculus wedged between our perception actions. In contrast, advocates fundamental function induce actions predict consequences those support survival prosperity host. Brains constantly test their hypotheses producing rather than searching for veridical objective world. Only can provide second opinion about relevance sensory inputs meaning interpretation inputs. inside-out framework, it not sensations teach build up its circuits. Instead, comes with preconfigured self-organized dynamics constrains how acts views Both anatomical physiological organizations are characterized enormous diversity which spans several orders magnitude. two ends continuous landscape give rise apparently distinct qualitative features. A small core strongly interconnected, highly active neurons provides fast “good-enough” answers in needy situations generalizations, whereas detailed precise solutions rely on contribution more isolated sluggish majority. non-egalitarian organization, preexisting nonsense patterns become meaningful through action-based experience. offers alternative strategy investigate operations cognitive faculties, as opposed outside-in approach explores preconceived ideas map onto structures.

Язык: Английский

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Specific Basal Forebrain–Cortical Cholinergic Circuits Coordinate Cognitive Operations

Journal of Neuroscience, Год журнала: 2018, Номер 38(44), С. 9446 - 9458

Опубликована: Окт. 31, 2018

Based on recent molecular genetics, as well functional and quantitative anatomical studies, the basal forebrain (BF) cholinergic projections, once viewed a diffuse system, are emerging being remarkably specific in connectivity. Acetylcholine (ACh) can rapidly selectively modulate activity of circuits ACh release be coordinated multiple areas that related to particular aspects cognitive processing. This review discusses how combination new approaches with more established techniques used finally reveal neurons, together other BF provide temporal structure for behavior, contribute local cortical state regulation, coordinate between different functionally circuits. modulates dynamics encoding attention within individual circuits, allows important transitions during sleep, shapes fidelity sensory processing by changing correlation neural firing. The importance this system integrated fluid behavioral function is underscored its disease-modifying role; demise neurons has long been Alzheimer's disease studies have revealed involvement modulation anxiety-related Therefore, plays pivotal role modulating brain sleep foretold intricacies map.

Язык: Английский

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A VTA GABAergic Neural Circuit Mediates Visually Evoked Innate Defensive Responses

Neuron, Год журнала: 2019, Номер 103(3), С. 473 - 488.e6

Опубликована: Июнь 12, 2019

Язык: Английский

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Neuromodulation in circuits of aversive emotional learning

Nature Neuroscience, Год журнала: 2019, Номер 22(10), С. 1586 - 1597

Опубликована: Сен. 24, 2019

Язык: Английский

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Spatiotemporally heterogeneous coordination of cholinergic and neocortical activity

Nature Neuroscience, Год журнала: 2022, Номер 25(12), С. 1706 - 1713

Опубликована: Ноя. 28, 2022

Язык: Английский

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Freezing revisited: coordinated autonomic and central optimization of threat coping

Nature reviews. Neuroscience, Год журнала: 2022, Номер 23(9), С. 568 - 580

Опубликована: Июнь 27, 2022

Язык: Английский

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Vagus nerve stimulation drives selective circuit modulation through cholinergic reinforcement

Neuron, Год журнала: 2022, Номер 110(17), С. 2867 - 2885.e7

Опубликована: Июль 19, 2022

Язык: Английский

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Top-down regulation of motivated behaviors via lateral septum sub-circuits

Molecular Psychiatry, Год журнала: 2022, Номер 27(8), С. 3119 - 3128

Опубликована: Май 18, 2022

Abstract How does cognition regulate innate behaviors? While the cognitive functions of cortex have been extensively studied, we know much less about how can motivated behaviors to fulfill physiological, safety and social needs. Selection appropriate depends on external stimuli past experiences that helps scale priorities. With its abundant inputs from neocortical allocortical regions, lateral septum (LS) is ideally positioned integrate perception experience signals in order activity hypothalamic midbrain nuclei control behaviors. In addition, LS receives numerous subcortical modulatory inputs, which represent animal internal states also participate this regulation. perspective, argue sub-circuits distinct by integrating neural neocortical, neuromodulatory inputs. propose inhibition between may allow emergence functional units orchestrates competing

Язык: Английский

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