Asian Journal of Pharmaceutical Sciences,
Год журнала:
2024,
Номер
19(2), С. 100903 - 100903
Опубликована: Март 11, 2024
Radiotherapy
is
a
well-established
cytotoxic
therapy
for
local
solid
cancers,
utilizing
high-energy
ionizing
radiation
to
destroy
cancer
cells.
However,
this
method
has
several
limitations,
including
low
energy
deposition,
severe
damage
surrounding
normal
cells,
and
high
tumor
resistance
radiation.
Among
various
radiotherapy
methods,
boron
neutron
capture
(BNCT)
emerged
as
principal
approach
improve
the
therapeutic
ratio
of
malignancies
reduce
lethality
tissue,
but
it
remains
deficient
in
terms
insufficient
accumulation
well
short
retention
time,
which
limits
curative
effect.
Recently,
series
radiosensitizers
that
can
selectively
accumulate
specific
organelles
cells
have
been
developed
precisely
target
radiotherapy,
thereby
reducing
side
effects
tissue
damage,
overcoming
radioresistance,
improving
radiosensitivity.
In
review,
we
mainly
focus
on
field
nanomedicine-based
discuss
organelle-targeted
radiosensitizers,
specifically
nucleus,
mitochondria,
endoplasmic
reticulum
lysosomes.
Furthermore,
carriers
used
BNCT
are
particularly
presented.
Through
demonstrating
recent
developments
radiosensitization,
hope
provide
insight
into
design
clinical
treatment.
Experimental & Molecular Medicine,
Год журнала:
2023,
Номер
55(4), С. 706 - 715
Опубликована: Апрель 3, 2023
Abstract
Proliferating
cancer
cells
rely
largely
on
glutamine
for
survival
and
proliferation.
Glutamine
serves
as
a
carbon
source
the
synthesis
of
lipids
metabolites
via
TCA
cycle,
well
nitrogen
amino
acid
nucleotide
synthesis.
To
date,
many
studies
have
explored
role
metabolism
in
cancer,
thereby
providing
scientific
rationale
targeting
treatment.
In
this
review,
we
summarize
mechanism(s)
involved
at
each
step
metabolism,
from
transporters
to
redox
homeostasis,
highlight
areas
that
can
be
exploited
clinical
Furthermore,
discuss
mechanisms
underlying
cell
resistance
agents
target
strategies
overcoming
these
mechanisms.
Finally,
effects
blockade
tumor
microenvironment
explore
maximize
utility
blockers
EBioMedicine,
Год журнала:
2024,
Номер
107, С. 105301 - 105301
Опубликована: Авг. 23, 2024
Increasing
evidence
indicates
that
immunotherapy
is
hindered
by
a
hostile
tumor
microenvironment
(TME)
featured
with
deprivation
of
critical
nutrients
and
pooling
immunosuppressive
metabolites.
Tumor
cells
outcompete
immune
effector
for
essential
nutrients.
Meanwhile,
wide
range
cell-derived
toxic
metabolites
exerts
negative
impacts
on
anti-tumor
response,
diminishing
the
efficacy
immunotherapy.
Nanomedicine
excellent
targetability
offers
novel
approach
to
improving
cancer
via
metabolically
reprogramming
TME.
Herein,
we
review
recent
strategies
enhancing
immunotherapeutic
effects
through
rewiring
metabolism
nanomedicine.
Attention
drawn
immunometabolic
tactics
stromal
in
TME
Additionally,
discuss
future
directions
developing
metabolism-regulating
nanomedicine
precise
efficacious
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Окт. 18, 2024
Immunotherapy
has
made
significant
strides
in
cancer
treatment,
particularly
through
immune
checkpoint
blockade
(ICB),
which
shown
notable
clinical
benefits
across
various
tumor
types.
Despite
the
transformative
impact
of
ICB
treatment
therapy,
only
a
minority
patients
exhibit
positive
response
to
it.
In
with
solid
tumors,
those
who
respond
well
typically
demonstrate
an
active
profile
referred
as
"hot"
(immune-inflamed)
phenotype.
On
other
hand,
non-responsive
may
distinct
"cold"
(immune-desert)
phenotype,
differing
from
features
tumors.
Additionally,
there
is
more
nuanced
"excluded"
positioned
between
and
categories,
known
type.
Effective
differentiation
understanding
intrinsic
factors,
characteristics,
TME,
external
factors
are
critical
for
predicting
results.
It
widely
accepted
that
therapy
exerts
profound
effect
on
limited
efficacy
against
or
"altered"
necessitating
combinations
therapeutic
modalities
enhance
cell
infiltration
into
tissue
convert
tumors
ones.
Therefore,
aligning
traits
this
review
systematically
delineates
respective
influencing
extensively
discusses
varied
approaches
drug
targets
based
assess
efficacy.
Trends in Immunology,
Год журнала:
2023,
Номер
44(3), С. 231 - 244
Опубликована: Фев. 9, 2023
T
cell
subsets
adapt
and
rewire
their
metabolism
according
to
functions
surrounding
microenvironment.
Whereas
naive
cells
rely
on
mitochondrial
metabolic
pathways
characterized
by
low
nutrient
requirements,
effector
induce
kinetically
faster
generate
the
biomass
energy
needed
for
proliferation
cytokine
production.
Recent
findings
support
concept
that
alterations
in
also
affect
epigenetics
of
cells.
In
this
review
we
discuss
connections
between
epigenetic
changes
such
as
histone
post-translational
modifications
(PTMs)
DNA
methylation,
well
'extra-metabolic'
roles
enzymes
molecules.
These
collectively
point
a
new
group
potential
therapeutic
targets
treatment
cell-dependent
autoimmune
diseases
cancers.
Lipids in Health and Disease,
Год журнала:
2024,
Номер
23(1)
Опубликована: Фев. 1, 2024
Abstract
Lipid
metabolism
in
cancer
cells
has
garnered
increasing
attention
recent
decades.
Cancer
thrive
hypoxic
conditions,
nutrient
deficiency,
and
oxidative
stress
cannot
be
separated
from
alterations
lipid
metabolism.
Therefore,
exhibit
increased
metabolism,
uptake,
lipogenesis
storage
to
adapt
a
progressively
challenging
environment,
which
contribute
their
rapid
growth.
Lipids
aid
cell
activation.
absorb
lipids
with
the
help
of
transporter
translocase
proteins
obtain
energy.
Abnormal
levels
series
synthases
over-accumulation
tumor
microenvironment
(TME).
reprogramming
plays
an
essential
role
TME.
are
closely
linked
several
immune
phenotypic
transformation.
The
further
promotes
immunosuppression,
leads
escape.
This
event
significantly
affects
progression,
treatment,
recurrence,
metastasis
cancer.
present
review
describes
TME
examines
connection
between
immunotherapy.
Clinical Epigenetics,
Год журнала:
2024,
Номер
16(1)
Опубликована: Фев. 8, 2024
Abstract
DNA
methylation
is
a
pivotal
epigenetic
modification
that
affects
gene
expression.
Tumor
immune
microenvironment
(TIME)
comprises
diverse
cells
and
stromal
components,
creating
complex
landscape
can
either
promote
or
inhibit
tumor
progression.
In
the
TIME,
has
been
shown
to
play
critical
role
in
influencing
cell
function
evasion.
regulates
differentiation,
responses,
TIME
composition
Targeting
offers
various
potential
avenues
for
enhancing
cytotoxicity
reducing
immunosuppression.
Recent
studies
have
demonstrated
of
patterns
infiltration
function.
However,
challenges
persist
understanding
precise
mechanisms
underlying
developing
selective
therapies,
effectively
integrating
these
therapies
with
other
antitumor
strategies.
conclusion,
both
interacts
thus
clinical
efficacy.
The
regulation
within
holds
significant
promise
advancement
immunotherapy.
Addressing
crucial
harnessing
full
interventions
enhance
responses
improve
patient
outcomes.
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer,
Год журнала:
2025,
Номер
unknown, С. 189259 - 189259
Опубликована: Янв. 1, 2025
As
immunosuppressive
cells,
Regulatory
T
cells
(Tregs)
exert
their
influence
on
tumor
immune
escape
within
the
microenvironment
(TME)
by
effectively
suppressing
activity
of
other
thereby
significantly
impeding
anti-tumor
response.
In
recent
years,
metabolic
characteristics
Tregs
have
become
a
focus
research,
especially
important
role
lipid
metabolism
in
maintaining
function
Tregs.
Consequently,
targeted
interventions
aimed
at
modulating
been
recognized
as
an
innovative
and
promising
approach
to
enhance
effectiveness
immunotherapy.
This
review
presents
comprehensive
overview
pivotal
regulating
Tregs,
with
specific
targeting
augment
responses.
Furthermore,
we
discuss
potential
opportunities
challenges
associated
this
strategy,
aiming
provide
novel
insights
for
enhancing
efficacy
cancer
