Curcumin-incorporated EGCG-based nano-antioxidants alleviate colon and kidney inflammation via antioxidant and anti-inflammatory therapy DOI Creative Commons
Qingqing Pan, Li Xie, Zhu Huang

и другие.

Regenerative Biomaterials, Год журнала: 2024, Номер 11

Опубликована: Янв. 1, 2024

Abstract Natural remedies are gaining attention as promising approaches to alleviating inflammation, yet their full potential is often limited by challenges such poor bioavailability and suboptimal therapeutic effects. To overcome these limitations, we have developed a novel nano-antioxidant (EK) based on epigallocatechin gallate (EGCG) aimed at enhancing the oral systemic bioavailability, well anti-inflammatory efficacy, of curcumin (Cur) in conditions acute colon kidney inflammation. EK synthesized using straightforward Mannich reaction between EGCG L-lysine (K), resulting formation oligomers. These oligomers spontaneously self-assemble into nanoparticles with spherical morphology an average diameter approximately 160 nm. In vitro studies reveal that exhibit remarkable radical-scavenging capabilities effectively regulate redox processes within macrophages, key component body’s inflammatory response. By efficiently encapsulating nanoparticles, create Cur@EK, formulation demonstrates synergistic effect. Specifically, Cur@EK significantly reduces levels pro-inflammatory cytokines TNF-α IL-6 while increasing cytokine IL-10 lipopolysaccharide-stimulated highlighting its potent properties. When administered either orally or intravenously, shows superior compared free exhibits pronounced effects mouse models ulcerative colitis injury. findings suggest platform not only enhances but also amplifies impact, offering new avenue for treatment management inflammation both contexts.

Язык: Английский

Metformin-based nanomedicines for reprogramming tumor immune microenvironment DOI
Jieyu Liu, Xiaoling Li, Yinggang Li

и другие.

Theranostics, Год журнала: 2024, Номер 15(3), С. 993 - 1016

Опубликована: Дек. 2, 2024

Immunotherapy has transformed current cancer management, and it achieved significant progress over last decades. However, an immunosuppressive tumor microenvironment (TME) diminishes the effectiveness of immunotherapy by suppressing activity immune cells facilitating immune-evasion. Adenosine monophosphate-activated protein kinase (AMPK), a key modulator cellular energy metabolism homeostasis, gained growing attention in anti-tumor immunity. Metformin is usually considered as cornerstone diabetes its role activating AMPK pathway also been extensively explored therapy although findings on remain inconsistent. nanomedicine formulation found to hold potential reprogramming TME through immunometabolic modulation both cells. This review elaborates foundation via metformin-based nanomedicines, offering valuable insights for next generation therapy.

Язык: Английский

Процитировано

28
Copper‐Based Bio‐Coordination Nanoparticle for Enhanced Pyroptosis‐Cuproptosis Cancer Immunotherapy through Redox Modulation and Glycolysis Inhibition DOI Open Access

Ju‐E Cun,

Ziyun He,

Fan Xi

и другие.

Small, Год журнала: 2025, Номер unknown

Опубликована: Янв. 5, 2025

Copper-based nanoparticles have garnered significant interest in cancer therapy due to their ability induce oxidative stress and cuproptosis cells. However, antitumor effectiveness is constrained by the dynamic redox balance metabolic shift between phosphorylation glycolysis. Here, a polydopamine-coated copper-α-ketoglutaric acid (α-KG) coordination polymer nanoparticle (CKPP) designed for combined pyroptosis-cuproptosis immunotherapy amplifying reactive oxygen species (ROS) production regulating cellular metabolism. The intracellular imbalance achieved through synergistic effects of α-KG-induced mitochondrial reprogramming, photothermally enhanced superoxide dismutase-like activity polydopamine, glutathione depletion copper ions. multifaceted modulation results substantial increase ROS levels, triggering subsequent pyroptosis Furthermore, α-KG shifts metabolism from glycolysis phosphorylation, thereby enhancing induced combination dyshomeostasis inhibition potent enhancement pyroptosis-cuproptosis-mediated therapy. In murine model colorectal cancer, CKPP exhibited remarkable anticancer effect, achieving tumor rate 96.3% complete eradication two out five cases. Overall, this bio-engineered metal-organic nanocomposite demonstrates potential treating immunotherapy.

Язык: Английский

Процитировано

2
Glutathione‐Driven Disassembly of Planar Organic Phototherapeutic Agents to Enhance Photodynamic‐Photothermal Therapy Performance for Nasopharyngeal Carcinoma DOI Open Access
Laiping Fang, Jianan Dai, Xuan Wang

и другие.

Small, Год журнала: 2025, Номер unknown

Опубликована: Янв. 2, 2025

The self-assembly of hydrophobic organic phototherapeutic agents (OPTAs) with expansive planar structures into nanoparticles (NPs) represents a pivotal strategy to bolster their biocompatibility. However, the tight molecular packing within these NPs significantly influences generation reactive oxygen species (ROS) and photothermal conversion efficiency (PCE), posing substantial hurdle elevating efficacy photodynamic therapy (PDT) (PTT) for such NPs. In this article, three OPTAs by donor engineering are synthesized. Notably, 4,8-Bis (5-phenylthiophen-2-yl)-6-(2-ethylhexyl)-[1,2,5] thiadiazole [3,4-F] benzotriazole (BTBT), which incorporates benzene ring as donor, exhibits highest ROS optimal capability. To further augment overall phototheranostic potential BTBT NPs, glutathione (GSH)-driven disassembly is employed. This not only alleviates aggregation-caused quenching (ACQ) effect on but also facilitates enhanced free rotation. As result, production sees tenfold increase, temperature rises 8.3 °C, achieving PCE 77.03%. summary, versatile proposed that concurrently enhances performance both PDT PTT in OPTAs, while advancing state-of-the-art nasopharyngeal carcinoma (NPC) treatment.

Язык: Английский

Процитировано

1
Co-activating STING-TLR9 pathways promotes radiotherapy-induced cancer vaccination DOI
Yuling Sun, Liang Liu,

Huilan He

и другие.

Journal of Controlled Release, Год журнала: 2025, Номер 379, С. 327 - 343

Опубликована: Янв. 14, 2025

Язык: Английский

Процитировано

1
Self-assembled aptamer nanoparticles for enhanced recognition and anticancer therapy through a lysosome-independent pathway DOI

Fangfang Xia,

Qiao Duan, Qingming Zhang

и другие.

Acta Biomaterialia, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

1
Nanomedicine in Immunotherapy for Non‐Small Cell Lung Cancer: Applications and Perspectives DOI Open Access
Shuangsi Liao, Xiaoling Li, You Lü

и другие.

Small Methods, Год журнала: 2025, Номер unknown

Опубликована: Янв. 28, 2025

Abstract Non‐small cell lung cancer (NSCLC) has a strikingly high incidence rate globally. Although immunotherapy brings great breakthrough in its clinical treatment of NSCLC, significant challenges still need to be overcome. The development novel multi‐functional nanomedicines the realm tumor offers promising opportunities for NSCLC patients, as exhibit advantages, including specific targeting cells, improved drug bioavailability, reduced systemic toxicity, and overcoming immune resistance. In this review, core features current status strategies checkpoint blockade, antibody–drug conjugates, engagers, adoptive vaccines, are surveyed. Particular emphasis is placed on recent that boost these strategies. Nanomedicine can provide perspectives immunotherapy.

Язык: Английский

Процитировано

1
Targeted codelivery of nitric oxide and hydrogen sulfide for enhanced antithrombosis efficacy DOI
Weiliang Deng,

Zhixin Xu,

Hua Tong

и другие.

Bioactive Materials, Год журнала: 2025, Номер 48, С. 29 - 42

Опубликована: Фев. 13, 2025

Язык: Английский

Процитировано

1
Machine Learning‐Driven Prediction, Preparation, and Evaluation of Functional Nanomedicines Via Drug–Drug Self‐Assembly DOI Creative Commons
Chengyuan Zhang, Yuchuan Yuan,

Q.L. Xia

и другие.

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Янв. 10, 2025

Abstract Small molecules as nanomedicine carriers offer advantages in drug loading and preparation. Selecting effective small for stable nanomedicines is challenging. This study used artificial intelligence (AI) to screen combinations self‐assembling nanomedicines, employing physiochemical parameters predict formation via machine learning. Non‐Steroidal Anti‐Inflammatory Drugs (NSAIDs) are identified antineoplastic drugs, with high loading. Nanomedicines, PEG‐coated indomethacin/paclitaxel (PiPTX), laminarin‐modified (LiDOX), developed extended circulation active targeting functions. Indomethacin/paclitaxel iDOX exhibits pH‐responsive release the tumor microenvironment. These enhance anti‐tumor effects reduce side effects, offering a rapid approach clinical development.

Язык: Английский

Процитировано

0
ODSEI Chip: An Open 3D Microfluidic Platform for Studying Tumor Spheroid‐Endothelial Interactions DOI Creative Commons
Jooyoung Ro, Junyoung Kim, Juhee Park

и другие.

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Янв. 13, 2025

Abstract Current in vitro models of 3D tumor spheroids within the microenvironment have emerged as promising tools for understanding progression and potential drug responses. However, creating with functional vasculature remains challenging a controlled high‐throughput manner. Herein, novel open 3D‐microarray platform is presented spheroid‐endothelium interaction (ODSEI) chip, capable arraying more than 1000 on top vasculature, compartmentalized single spheroid‐level analysis resistance, allows extraction specific further analysis. As proof concept, crosstalk between breast cancer monitored, validating roles endothelial cells acquired tamoxifen resistance. Cancer exhibited reduced sensitivity to presence vasculature. Further through single‐cell RNA sequencing extracted protein arrays elucidated gene expression profiles cytokines associated particularly involving TNF‐α pathway via NF‐κB mTOR signaling. By targeting highly expressed (IL‐8, TIMP1) identified, resistance spheroid can be effectively reversed. In summary, ODSEI chip study various contexts, leading improved insights into biology therapeutic strategies.

Язык: Английский

Процитировано

0
Computer‐Aided Design of Self‐Assembled Nanoparticles to Enhance Cancer Chemoimmunotherapy via Dual‐Modulation Strategy DOI Open Access
Xiaoting Shan, Ying Cai,

Binyu Zhu

и другие.

Advanced Healthcare Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 19, 2025

Abstract The rational design of self‐assembled compounds is crucial for the highly efficient development carrier‐free nanomedicines. Herein, based on computer‐aided strategies, important physicochemical properties are identified to guide compounds. Then, pharmacophore hybridization strategy used self‐assemble nanoparticles by preparing new chemical structures combining groups different bioactive Hydroxychloroquine grafted with lipophilic vitamin E succinate and then co‐assembled bortezomib fabricate nanoparticle. nanoparticle can reduce M2‐type tumor‐associated macrophages (TAMs) through lysosomal alkalization induce immunogenic cell death (ICD) nuclear factor‐κB (NF‐κB) inhibition in tumor cells. In mouse models, decreased levels TAMs, regulatory T cells, transforming growth factor‐β (TGF‐β), increase proportion cytotoxicity lymphocytes. Additionally, secretion Interleukin‐6 (IL‐6) inhibiting NF‐κB enhance programmed ligand‐1 (PD‐L1) checkpoint blockade therapy. hybridization‐derived provides a dual‐modulation reprogram microenvironment, which will efficiently chemoimmunotherapy against triple‐negative breast cancer.

Язык: Английский

Процитировано

0