Examination of the interaction of parameters for low-intensity focused ultrasound of the human motor cortex DOI Creative Commons

Areej Ennasr,

G. Anand Isaac,

Andrew Strohman

и другие.

Brain stimulation, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 1, 2024

Low-intensity focused ultrasound (LIFU) is a promising form of non-invasive neuromodulation characterized by rich parameter space that includes intensity, duration, duty cycle and pulsing strategy. The effect interaction these parameters to affect human brain activity poorly understood. A better understanding how interact critical advance LIFU as potential therapeutic.

Язык: Английский

Low-intensity focused ultrasound for human neuromodulation DOI
Wynn Legon, Andrew Strohman

Nature Reviews Methods Primers, Год журнала: 2024, Номер 4(1)

Опубликована: Дек. 19, 2024

Язык: Английский

Процитировано

4
Repetitive pulsed-wave ultrasound stimulation suppresses neural activity by modulating ambient GABA levels via effects on astrocytes DOI Creative Commons
Tatsuya Mishima,

Kenta Komano,

Marie Tabaru

и другие.

Frontiers in Cellular Neuroscience, Год журнала: 2024, Номер 18

Опубликована: Март 27, 2024

Ultrasound is highly biopermeable and can non-invasively penetrate deep into the brain. Stimulation with patterned low-intensity ultrasound induce sustained inhibition of neural activity in humans animals, potential implications for research therapeutics. Although mechanosensitive channels are involved, cellular molecular mechanisms underlying neuromodulation by remain unknown. To investigate mechanism action stimulation, we studied effects two types on synaptic transmission network using whole-cell recordings primary cultured hippocampal cells. Single-shot pulsed-wave (PW) or continuous-wave (CW) had no effect activity. By contrast, although repetitive CW stimulation also effect, PW persistently reduced spontaneous recurrent burst firing. This inhibitory was dependent extrasynaptic—but not synaptic—GABA A receptors, abolished under astrocyte-free conditions. Pharmacological activation astrocytic TRPA1 mimicked increasing tonic GABA current induced ambient GABA. blockade ultrasound. These findings suggest that used our study does have a direct function but instead exerts its neuromodulatory through modulation levels via characteristics TRPA1, which expressed astrocytes.

Язык: Английский

Процитировано

3
Dynamical and individualised approach of transcranial ultrasound neuromodulation effects in non-human primates DOI Creative Commons
Cyril Atkinson-Clément,

Mohammad Alkhawashki,

James Ross

и другие.

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Май 24, 2024

Low-frequency transcranial ultrasound stimulation (TUS) allows to alter brain functioning with a high spatial resolution and reach deep targets. However, the time-course of TUS effects remains largely unknown. We applied on three targets for different monkeys: anterior medial prefrontal cortex, supplementary motor area perigenual cingulate cortex. For each, one resting-state fMRI was acquired between 30 150 min after as well without (control). captured seed-based connectivity changes dynamically an individual basis. also assessed individuals homogeneity features that predicted changes. found prompts heterogenous functional alterations yet retain certain consistent changes; we identified 6 time-courses including transient long duration alterations; notable degree accuracy could partially be predicted. Altogether, our results highlight induces heterogeneous alterations. On more technical point, emphasize need consider over-time rather than just observed during snapshot; inter-individual variability since highly from another.

Язык: Английский

Процитировано

3
Low-intensity focused ultrasound to the insula differentially modulates the heartbeat-evoked potential: a proof-of-concept study DOI
Andrew Strohman,

G. Anand Isaac,

Brighton Payne

и другие.

Clinical Neurophysiology, Год журнала: 2024, Номер unknown

Опубликована: Сен. 1, 2024

Язык: Английский

Процитировано

3
Examination of the interaction of parameters for low-intensity focused ultrasound of the human motor cortex DOI Creative Commons

Areej Ennasr,

G. Anand Isaac,

Andrew Strohman

и другие.

Brain stimulation, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 1, 2024

Low-intensity focused ultrasound (LIFU) is a promising form of non-invasive neuromodulation characterized by rich parameter space that includes intensity, duration, duty cycle and pulsing strategy. The effect interaction these parameters to affect human brain activity poorly understood. A better understanding how interact critical advance LIFU as potential therapeutic.

Язык: Английский

Процитировано

3