The cognitive impact of light: illuminating ipRGC circuit mechanisms

Nature reviews. Neuroscience, Год журнала: 2024, Номер 25(3), С. 159 - 175

Опубликована: Янв. 26, 2024

Язык: Английский

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Structures of human gastrin-releasing peptide receptors bound to antagonist and agonist for cancer and itch therapy

Proceedings of the National Academy of Sciences, Год журнала: 2023, Номер 120(6)

Опубликована: Фев. 1, 2023

Gastrin releasing peptide receptor (GRPR), a member of the bombesin (BBN) G protein-coupled receptors, is aberrantly overexpressed in several malignant tumors, including those breast, prostate, pancreas, lung, and central nervous system. Additionally, it also mediates non-histaminergic itch pathological conditions mice. Thus, GRPR could be an attractive target for cancer therapy. Here, we report inactive state crystal structure human complex with non-peptide antagonist PD176252, as well two active cryo-electron microscopy (cryo-EM) structures bound to endogenous agonist gastrin-releasing synthetic BBN analog [D-Phe6, β-Ala11, Phe13, Nle14] Bn (6-14), Gq heterotrimers. These revealed molecular mechanisms ligand binding, activation, proteins signaling GRPR, which are expected accelerate structure-based design antagonists agonists treatments pruritus.

Язык: Английский

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The neural basis of affective empathy: what is known from rodents

Neuropharmacology, Год журнала: 2025, Номер unknown, С. 110347 - 110347

Опубликована: Фев. 1, 2025

Язык: Английский

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Role of the GRP/GRPR System in Regulating Brain Functions

ACS Chemical Neuroscience, Год журнала: 2023, Номер 14(19), С. 3588 - 3598

Опубликована: Сен. 13, 2023

Re-examining the relationship between neuropeptide systems and neural circuits will help us to understand more intensively critical role of neuropeptides in brain function as responsible for specific functions are gradually revealed. Gastrin-releasing peptide receptors (GRPRs) Gαq-coupling widely distributed brain, including hippocampus, amygdala, hypothalamus, nucleus tractus solitarius (NTS), suprachiasmatic (SCN), paraventricular hypothalamus (PVN), preoptic area (POA), preBötzinger complex (preBötC), etc., implying GRP/GRPR system is involved modulating multiple functions. In this review, we focus on functionality GRPR neurons regulatory memory cognition, fear, depression anxiety, circadian rhythms, contagious itch, gastric acid secretion, food intake, body temperature, sighing behavior. It can be found that usually centered a certain or anatomical structure modulates richer behaviors by connecting with additional different nuclei. order explain mechanism system, precise intervention methods needed.

Язык: Английский

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An insular cortical circuit required for itch sensation and aversion

Current Biology, Год журнала: 2024, Номер 34(7), С. 1453 - 1468.e6

Опубликована: Март 13, 2024

Язык: Английский

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Tac1-expressing neurons in the central amygdala predominantly mediate histamine-induced itch by receiving inputs from parabrachial Tac1-expressing neurons

Brain Research, Год журнала: 2025, Номер unknown, С. 149492 - 149492

Опубликована: Фев. 1, 2025

Язык: Английский

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Distinct oxytocin signaling pathways synergistically mediate rescue-like behavior in mice

Proceedings of the National Academy of Sciences, Год журнала: 2025, Номер 122(17)

Опубликована: Апрель 23, 2025

Spontaneous rescue behavior enhances the well-being and survival of social animals, yet neural mechanisms underlying recognition response to conspecifics in need remain unclear. Here, we report that observer mice experience distress when encountering anesthetized conspecifics, prompting spontaneous rescue-like toward unconscious mice. This facilitates earlier awakening while simultaneously alleviating stress helper Our findings reveal endogenous oxytocin (OXT) release from hypothalamic paraventricular nucleus (PVN) receptor (OXTR) central amygdala (CeA) regulates emotional component behavior. In contrast, OXT PVN OXTR dorsal bed stria terminalis (dBNST) mediates motor Furthermore, demonstrate these two pathways exhibited distinct temporal dynamics functional roles. The -OXTR CeA pathway is activated a transient intense manner, acting as trigger for behavior, whereas dBNST responds sustained ensuring continuation These highlight remarkable ability rodents engage targeted helping suggest subcortical oxytocinergic selectively synergistically regulate aspects

Язык: Английский

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Multimodality in the Collicular Pathway: Towards Compensatory Visual Processes

Cells, Год журнала: 2025, Номер 14(9), С. 635 - 635

Опубликована: Апрель 25, 2025

The integration of multisensory inputs plays a crucial role in shaping perception and behavior, particularly the visual system. collicular pathway, encompassing optic tectum non-mammalian vertebrates superior colliculus (SC) mammals, is key hub for integrating sensory information mediating adaptive motor responses. Comparative studies across species reveal evolutionary adaptations that enhance processing contribute to compensatory mechanisms following neuronal injury. present review outlines structure function pathways, emphasizing retinocollicular projections, their integration, which depends on synaptic convergence afferents conveying from different modalities. cellular underlying multimodal remain be fully clarified, further investigations are needed clarify link between activity response stimulation behavioral involving activity. By exploring interplay fundamental neuroscience translational applications, we aim address as pivotal target its potential rehabilitation strategies.

Язык: Английский

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Neural-circuit architecture underlying non-image-forming visual functions

Current Opinion in Neurobiology, Год журнала: 2025, Номер 93, С. 103052 - 103052

Опубликована: Май 24, 2025

Язык: Английский

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Light, Sound, and Melatonin: Investigating Multisensory Pathways for Visual Restoration

Medicina, Год журнала: 2025, Номер 61(6), С. 1009 - 1009

Опубликована: Май 28, 2025

Multisensory integration is fundamental for coherent perception and interaction with the environment. While cortical mechanisms of multisensory convergence are well studied, emerging evidence implicates specialized retinal ganglion cells—particularly melanopsin-expressing intrinsically photosensitive cells (ipRGCs)—in crossmodal processing. This review explores how hierarchical brain networks (e.g., superior colliculus, parietal cortex) ipRGCs jointly shape behavior, focusing on their in plasticity. We highlight as gatekeepers environmental light cues. Their anatomical projections to areas like colliculus established, although direct role human audiovisual remains limited. Through melanopsin signaling subcortical projections, they may modulate downstream processing, potentially enhancing salience inputs. A key theme spatiotemporal synergy between melatonin: encodes light, while melatonin fine-tunes ipRGC activity synaptic plasticity, creating time-sensitive rehabilitation windows. However, linking limited, primarily inferred from functional studies. Future implementations should prioritize quantitative optical metrics melanopic irradiance, spectral composition) standardize light-based interventions enhance reproducibility. Nonetheless, we propose a translational framework combining stimuli cues) circadian-timed recovery visual disorders hemianopia spatial neglect. By bridging biology systems neuroscience, this redefines retina’s processing offers novel, mechanistically grounded strategies neurorehabilitation.

Язык: Английский

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