Light-eye-body axis: exploring the network from retinal illumination to systemic regulation DOI Creative Commons
Yi Zeng, Rong Rong,

Mengling You

и другие.

Theranostics, Год журнала: 2024, Номер 15(4), С. 1496 - 1523

Опубликована: Дек. 31, 2024

The human body is an intricate system, where diverse and complex signaling among different organs sustains physiological activities. eye, as a primary organ for information acquisition, not only plays crucial role in visual perception but also, increasing evidence suggests, exerts broad influence on the entire through circuits upon receiving light signals which called non-image-forming vision. However, extent mechanisms of light's impact eyes remain insufficiently explored. There also dearth comprehensive reviews elucidating interplay between light, systemic connections to body. Herein, we propose concept light-eye-body axis systematically encapsulate extensive effects received by retina We reviewed visual-neural structure basis axis, summarized mechanism regulate whole current research status challenges within pathological processes involved axis. Future should aim expand explore its deeper mechanisms. Understanding investigating will contribute improving lighting conditions optimize health guide establishment phototherapy standards clinical practice.

Язык: Английский

Scheduled feeding improves behavioral outcomes and reduces inflammation in a mouse model of Fragile X syndrome DOI Open Access
Huei‐Bin Wang,

Natalie E Smale,

Sarah H. Brown

и другие.

Опубликована: Фев. 21, 2025

Fragile X syndrome (FXS) is a neurodevelopmental disorder caused by the abnormal expansion of CGG repeats in fragile mental retardation 1 (FMR1) gene. Many FXS patients experience sleep disruptions, and we sought to explore these symptoms along with possible benefits scheduled feeding intervention using Fmr1 knockout (KO) mouse model. These mutants displayed clear evidence for circadian disturbances including delay onset fragmented activity rhythms increases cycle-to-cycle variability. Importantly, KO mice exhibited deficits their behavioral response light reduced masking, longer time resetting shifts Light-Dark cycle, altered synchronization skeleton photoperiod lower magnitude light-induced phase rhythms. Investigation retinal input surprachiasmatic nucleus (SCN) neurotracer cholera toxin (β subunit) quantification light-evoked cFos expression SCN revealed an innervation KO, providing mechanistic explanation observed deficits. Interestingly, disruptions social repetitive behaviors correlated duration fragmentation. Understanding nature deficits, decided apply regimen (6-hr/18-hr feed/fast cycle) as circadian-based strategy boast independently light. This significantly improved mutants. Strikingly, ameliorated interactions well levels Interferon-gamma Interleukin-12 mutants, suggesting that timed eating may be effective way lessen inflammation. Collectively, this work adds support efforts develop based interventions help disorders.

Язык: Английский

Процитировано

1
Scheduled feeding improves behavioral outcomes and reduces inflammation in a mouse model of Fragile X syndrome DOI Open Access
Huei‐Bin Wang,

Natalie E Smale,

Sarah H. Brown

и другие.

Опубликована: Фев. 21, 2025

Fragile X syndrome (FXS) is a neurodevelopmental disorder caused by the abnormal expansion of CGG repeats in fragile mental retardation 1 (FMR1) gene. Many FXS patients experience sleep disruptions, and we sought to explore these symptoms along with possible benefits scheduled feeding intervention using Fmr1 knockout (KO) mouse model. These mutants displayed clear evidence for circadian disturbances including delay onset fragmented activity rhythms increases cycle-to-cycle variability. Importantly, KO mice exhibited deficits their behavioral response light reduced masking, longer time resetting shifts Light-Dark cycle, altered synchronization skeleton photoperiod lower magnitude light-induced phase rhythms. Investigation retinal input surprachiasmatic nucleus (SCN) neurotracer cholera toxin (β subunit) quantification light-evoked cFos expression SCN revealed an innervation KO, providing mechanistic explanation observed deficits. Interestingly, disruptions social repetitive behaviors correlated duration fragmentation. Understanding nature deficits, decided apply regimen (6-hr/18-hr feed/fast cycle) as circadian-based strategy boast independently light. This significantly improved mutants. Strikingly, ameliorated interactions well levels Interferon-gamma Interleukin-12 mutants, suggesting that timed eating may be effective way lessen inflammation. Collectively, this work adds support efforts develop based interventions help disorders.

Язык: Английский

Процитировано

0
Exploring the Impacts of Semi-Transparent Photovoltaic Glazing on Human Visual and Non-Visual Comfort: An Experimental Case Study in Hong Kong DOI Creative Commons
Wanting Wang, Changying Xiang

Journal of Building Engineering, Год журнала: 2025, Номер unknown, С. 112184 - 112184

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
Loss of Bmal1 impairs the glutamatergic light input to the SCN in mice DOI Creative Commons
Hüseyin Korkmaz, Max Anstötz,

Tim Wellinghof

и другие.

Frontiers in Cellular Neuroscience, Год журнала: 2025, Номер 19

Опубликована: Фев. 27, 2025

Glutamate represents the dominant neurotransmitter that conveys light information to brain, including suprachiasmatic nucleus (SCN), central pacemaker for circadian system. The neuronal and astrocytic glutamate transporters are crucial maintaining efficient glutamatergic signaling. In SCN, nerve terminals from retina terminate on vasoactive intestinal polypeptide (VIP) neurons, which essential functions. To date, little is known about role of core clock gene, Bmal1, in neurotransmission signal various brain regions. aim this study was further elucidate Bmal1 SCN. We therefore examined spontaneous rhythmic locomotor activity, glial transporters, as well ultrastructure synapse between retinal ganglion cells (RGCs) SCN adult male Bmal1-/- mice. found deletion affects light-mediated behavior mice, decreases thickness vesicular (vGLUT1, 2) retina. Within immunoreaction vGLUT1, 2, (GLAST) VIP decreased while concentration elevated. At level, presynaptic were enlarged distance synaptic vesicles cleft increased, indicative a decrease readily releasable pool at excitatory synapses Bmal1-/-. Our data suggests transmission behavioral responses light.

Язык: Английский

Процитировано

0
Examining the role of the photopigment melanopsin in the striatal dopamine response to light DOI Creative Commons

L Sofia Gonzalez,

Austen A Fisher,

Kassidy E Grover

и другие.

Frontiers in Systems Neuroscience, Год журнала: 2025, Номер 19

Опубликована: Апрель 2, 2025

The mesolimbic dopamine system is a set of subcortical brain circuits that plays key role in reward processing, reinforcement, associative learning, and behavioral responses to salient environmental events. In our previous studies the dopaminergic response visual stimuli, we observed release lateral nucleus accumbens (LNAc) mice encoded information about rate magnitude rapid luminance changes from darkness. Light-evoked were rate-dependent, robust time testing or stimulus novelty, required phototransduction by rod cone opsins. However, it unknown if these also involve non-visual opsins, such as melanopsin, primary photopigment expressed intrinsically photosensitive retinal ganglion cells (ipRGCs). current study, evaluated melanopsin light LNAc using genetically sensor dLight1 fiber photometry. By measuring light-evoked across broad irradiance wavelength range constitutive (Opn4) knockout mice, able provide new insights into ability opsins regulate stimuli.

Язык: Английский

Процитировано

0
A Pilot Study Exploring the Impact of Daylight Gradient on Occupant in Underground Space DOI Creative Commons
Hang Su, Weizhi Wei, Xiangjie Liu

и другие.

Developments in the Built Environment, Год журнала: 2025, Номер unknown, С. 100658 - 100658

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Impact of artificial colored lights on performance in working memory task DOI

V Divya Vani,

Pooja Ojha,

Mahesh Arjundan Gadhvi

и другие.

Acta Psychologica, Год журнала: 2025, Номер 256, С. 105001 - 105001

Опубликована: Апрель 14, 2025

Язык: Английский

Процитировано

0
Nervous system in colorectal cancer DOI
Chunjie Xu, Chunhui Jiang, Yuan Tian

и другие.

Cancer Letters, Год журнала: 2024, Номер unknown, С. 217431 - 217431

Опубликована: Дек. 1, 2024

Язык: Английский

Процитировано

3
Hallmarks of aging in age-related macular degeneration and age-related neurological disorders: novel insights into common mechanisms and clinical relevance DOI
Stela Vujosevic,

Celeste Limoli,

Igor Kozak

и другие.

Eye, Год журнала: 2024, Номер unknown

Опубликована: Сен. 17, 2024

Язык: Английский

Процитировано

2
Blue light-driven cell cycle arrest in thyroid cancer via Retinal-OPN3 complex DOI Creative Commons

Changrui Zhao,

Jiaqiang Bo,

Tianyu Li

и другие.

Cell Communication and Signaling, Год журнала: 2024, Номер 22(1)

Опубликована: Ноя. 1, 2024

Papillary thyroid carcinoma (PTC) is the most common type of malignancy, with a rising incidence. Traditional treatments, such as thyroidectomy and radiotherapy, often lead to significant side effects, including impaired function. Therefore, there an urgent need for non-invasive therapeutic approaches. This study aims explore potential photobiomodulation therapy (PBMT), treatment using specific wavelengths light, in management PTC.

Язык: Английский

Процитировано

2