Physiological Reports,
Год журнала:
2024,
Номер
12(21)
Опубликована: Ноя. 1, 2024
Abstract
Alterations
in
the
gut
microbiome
have
been
linked
to
obesity,
with
maternal
high‐fat
diet
(HF)
playing
a
role
shaping
offspring
composition.
However,
sex‐specific
responses
HF
and
impact
of
subsequent
dietary
challenges
remain
unclear.
This
study
investigated
effects
on
microbiota
structure
predicted
functional
profile
response
short‐term
postnatal
exposure
focus
responses.
Female
male
control
(C)
or
were
weaned
onto
C
diet.
Offspring
euthanized
at
13
weeks
age
cecal
contents
collected
for
bacterial
taxonomic
profiling.
Maternal
reduced
α‐diversity,
notably
Sex‐specific
differences
observed
microbial
composition
potential.
Furthermore,
influence
community
potential
varied
depending
led
increased
relative
abundance
Corynebacterium
female
decreased
Akkermansia
Roseburia
offspring.
These
findings
underscore
sexually
dimorphic
nature
function,
implications
developmental
programming
metabolic
health.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Март 13, 2024
Due
to
the
physiological
alteration
during
pregnancy,
maternal
gut
microbiota
changes
following
metabolic
processes.
Recent
studies
have
revealed
that
is
closely
associated
with
immune
microenvironment
in
utero
pregnancy
and
plays
a
vital
role
specific
complications,
including
preeclampsia,
gestational
diabetes,
preterm
birth
recurrent
miscarriages.
Some
other
evidence
has
also
shown
aberrant
increases
risk
of
various
diseases
offspring,
such
as
allergic
neurodevelopmental
disorders,
through
alignment
between
mother
fetus
possible
intrauterine
microbiota.
Probiotics
high-fiber
diet
are
effective
inventions
prevent
mothers
fetuses
from
diseases.
In
this
review,
we
summarize
development
complications
health
condition
future
generations
perspective
immunology,
which
may
provide
new
therapeutic
strategies
for
management
offspring.
Trillions
of
microbes
live
symbiotically
in
the
host,
specifically
mucosal
tissues
such
as
gut.
Recent
advances
metagenomics
and
metabolomics
have
revealed
that
gut
microbiota
plays
a
critical
role
regulation
host
immunity
metabolism,
communicating
through
bidirectional
interactions
microbiota-gut-brain
axis
(MGBA).
The
regulates
both
systemic
contributes
to
neurodevelopment
behaviors
host.
With
aging,
composition
changes,
emerging
studies
linked
these
shifts
microbial
populations
age-related
neurological
diseases
(NDs).
Preclinical
demonstrated
microbiota-targeted
therapies
can
improve
behavioral
outcomes
by
modulating
microbial,
metabolomic,
immunological
profiles.
In
this
review,
we
discuss
pathways
brain-to-gut
or
gut-to-brain
signaling
summarize
metabolites
across
lifespan
disease.
We
highlight
recent
investigating
1)
changes
with
aging;
2)
how
aging
maternal
microbiome
affect
offspring
health;
3)
contribution
chronic
(e.g.,
Parkinson's
disease,
Alzheimer's
disease
cerebral
amyloidosis),
acute
brain
injury,
including
ischemic
stroke
traumatic
injury.
Current Opinion in Clinical Nutrition & Metabolic Care,
Год журнала:
2024,
Номер
27(3), С. 297 - 303
Опубликована: Март 12, 2024
Purpose
of
review
Emerging
evidence
suggests
that
the
gut
microbiota
and
its
metabolites
regulate
neurodevelopment
cognitive
functioning
via
a
bi-directional
communication
system
known
as
microbiota-gut-brain
axis
(MGBA).
Recent
findings
The
MGBA
influences
brain
development
function
hypothalamic-pituitary
axis,
vagal
nerve,
immune
signaling,
bacterial
production
neurotransmitters,
microbial
like
short-chain
fatty
acids,
tryptophan
derivatives,
bile
acids.
Animal
studies
show
fetal
is
mediated
by
maternal
activation,
diet.
Furthermore,
manipulation
during
critical
windows
development,
antibiotic
exposure
fecal
transplantation,
can
affect
behavior
in
mice.
Evidence
from
human
studies,
particularly
preterm
infants,
also
disrupted
colonization
may
negatively
neurodevelopment.
Early
signatures
were
linked
to
favorable
adverse
neurodevelopmental
outcomes.
Summary
link
between
evident.
Future
including
experimental
larger
participant
cohort
with
longitudinal
analyses
microbes,
their
metabolites,
randomized
controlled
trials
are
warranted
further
elucidate
mechanisms
MGBA.
Identification
early,
predictive
markers
could
pave
way
for
novel
early
microbiota-based
intervention
strategies,
such
targeted
probiotics,
vaginal
or
aimed
at
improving
infant
Humans
and
other
animals
contain
multitudes
of
microorganisms
including
bacteria,
fungi,
viruses,
which
make
up
a
diverse
microbiome.
Across
body
sites
skin,
gastrointestinal
tract,
oral
cavity
there
are
distinct
microbial
niches
that
made
trillions
have
co‐evolved
to
inhabit
interact
with
the
host.
The
microbiome
also
interacts
changing
environment.
This
tripartite
interaction
between
host,
microbiome,
environment
suggests
communities
play
key
role
in
biological
processes
such
as
development
behaviors.
Over
past
two
decades,
emerging
research
continues
reveal
how
host
microbe
interactions
impact
nervous
system
signaling
behaviors,
influence
neurodevelopmental,
neurological,
neurodegenerative
disorders.
In
this
review,
we
will
describe
unique
features
maternal
exist
during
perinatal
period
discuss
evidence
for
function
offspring
development.
Finally,
then
postulate
can
modify
early
lasting
on
brain
health.
Genes,
Год журнала:
2023,
Номер
14(7), С. 1506 - 1506
Опубликована: Июль 24, 2023
Nutrition
and
metabolism
modify
epigenetic
signatures
like
histone
acetylation
DNA
methylation.
Histone
methylation
in
the
central
nervous
system
(CNS)
can
be
altered
by
bioactive
nutrients
gut
microbiome
via
gut-brain
axis,
which
turn
modulate
neuronal
activity
behavior.
Notably,
microbiome,
with
more
than
1000
bacterial
species,
collectively
contains
almost
three
million
functional
genes
whose
products
interact
millions
of
human
marks
30,000
a
dynamic
manner.
However,
genetic
makeup
shapes
composition,
food/nutrient
metabolism,
landscape,
as
well.
Here,
we
first
discuss
effect
changes
microbial
structure
composition
shaping
specific
alterations
brain
their
role
onset
progression
major
mental
disorders.
Afterward,
potential
interactions
among
maternal
diet/environmental
factors,
nutrition,
gastrointestinal
roles
accelerating
or
delaying
severe
illnesses
will
discussed.
We
also
provide
an
overview
association
between
oxidative
stress,
inflammation
through
mechanisms.
Finally,
present
some
underlying
mechanisms
involved
mediating
influence
probiotics
on
health
modifications.
It
has
been
discovered
that
the
reproductive
tract
contains
microbial
communities,
and
this
stable
microbiome
contributes
to
preservation
of
health.
Probiotics
have
suggested
as
a
potential
technique
improve
health
lower
risk
illness.
proposed
significant
element
affecting
couple's
health,
success
their
pregnancy,
kids
is
male
semen
microbiome.
reportedly
linked
improved
maternal
child
fertility,
mother-child
Although
microbiota
women
fertility
system
most
complex
found
among
upper
organs,
they
all
work
together
support
As
result
hormonal
effects
on
female
system,
probiotics
help
maintain
system's
homeostasis
affect
children.
Additionally,
parental
sexual
probiotic
treatment
newborn
gut
colonization
immune
development
via
bacterial
transmission
or
other
indirect
processes,
which
may
negative
effects.
The
influencing
advantages
synbiotic
management
involvement
studied
in
vivo
vitro
variety
beneficial
outcomes,
including
regulation
composition,
control
digestion,
advancement
cellular
defense,
enhancement
immunity
had
seen.
Here,
we
discuss
recent
research
function
wellness
also
synbiotics
for
prevention
disorders
are
related
it.
Recent
evidence
has
suggested
that
changes
in
maternal
gut
microbiota
early
life
may
generate
neurobiological
consequences
associated
with
psychiatric-related
abnormalities.
However,
the
number
of
studies
on
humans
investigating
this
problem
is
limited,
and
preclinical
findings
sometimes
conflict.
Therefore,
we
run
a
meta-analysis
to
examine
whether
disturbance
(MMD)
during
neurodevelopment
might
affect
offspring
adulthood.
We
found
thirteen
studies,
from
set
459
records
selected
by
strategy
registered
PROSPERO
(#289224),
target
evaluated
behavioral
outcomes
rodents
generated
dams
submitted
perinatal
enteric
perturbation.
The
analysis
revealed
significant
effect
size
(SMD
=
−0.51,
95%
CI
−0.79
−0.22,
p
<
.001,
T2
0.54,
I2
79.85%),
indicating
MMD
provoke
impairments
adult
offspring.
also
induces
for
reduction
sociability
behavior
−0.63,
−1.18
−0.07,
0.011,
0.30,
76.11%)
obsessive-compulsive-like
−0.68,
−0.01
−1.36,
0.009,
0.25,
62.82%)
parameters.
was
not
or
inconclusive
memory
anxiety-like
behavior,
schizophrenia-like
depressive-like
behavior.
experimental
vertically
transmitted
offspring,
negatively
impacting
parameters
related
psychiatric
disorders.
Life Sciences,
Год журнала:
2024,
Номер
354, С. 122948 - 122948
Опубликована: Авг. 6, 2024
The
gut-liver
axis
plays
a
pivotal
role
in
maintaining
body
homeostasis.
Disruption
of
the
is
linked
to
multitude
diseases,
including
metabolic
dysfunction-associated
steatotic
liver
disease
(MASLD).
Probiotic
strains
from
Lactobacillaceae
family
are
commonly
used
mitigate
experimental
MASLD.
Over
years,
numerous
studies
have
demonstrated
efficacy
these
probiotics,
often
focusing
on
outcome
disease.
This
review
aims
further
understand
MASLD
as
systemic
dysfunction
and
highlight
effects
probiotics
multi-organ
axis,
organs
such
gastrointestinal
tract,
pancreas,
muscle,
adipose
tissue,
immune
system.
We
specifically
discuss
evidence
how
supplementation
with
may
alleviate
by
not
only
restoring
health
but
also
modulating
physiology
other
organ
systems.
