Lactobacillus sp. for the Attenuation of Metabolic Dysfunction-Associated Steatotic Liver Disease in Mice DOI Creative Commons
Titilayo Olotu, Jessica M. Ferrell

Microorganisms, Год журнала: 2024, Номер 12(12), С. 2488 - 2488

Опубликована: Дек. 3, 2024

Probiotics are studied for their therapeutic potential in the treatment of several diseases, including metabolic dysfunction-associated steatotic liver disease (MASLD). Part significant progress made understanding pathogenesis steatosis has come from identifying complex interplay between gut microbiome and function. Recently, probiotics have shown beneficial effects prevention MASLD rodent models clinical trials. Numerous studies demonstrated promising lactic acid bacteria, especially genus Lactobacillus. Lactobacillus is a prominent bile hydrolase bacterium that involved biotransformation acids. This genus’ modulation microbiota also contributes to overall health; it controls microbial overgrowth, shapes intestinal pool, alleviates inflammation. narrative review offers comprehensive summary gut-liver axis attenuate MASLD. It highlights roles hepatic lipid metabolism, insulin resistance, inflammation fibrosis, synthesis attenuating

Язык: Английский

Effects of Selected Food Additives on the Gut Microbiome and Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) DOI Creative Commons
Sara Jarmakiewicz-Czaja, Aneta Sokal, Rafał Filip

и другие.

Medicina, Год журнала: 2025, Номер 61(2), С. 192 - 192

Опубликована: Янв. 22, 2025

The purpose of this article is to present selected food additives as disruptors normal intestinal homeostasis with a potential impact on the development metabolic dysfunction-associated steatotic liver disease (MASLD). A comprehensive literature search was conducted in three major electronic databases: PubMed, ScienceDirect, and Google Scholar. MASLD prevalent condition that closely related global rise obesity. Its pathogenesis multifactorial, genetic, environmental, factors playing key role. “multiple-hit” hypothesis suggests Western-style diet, rich ultra-processed foods, saturated fats, additives, combined low physical activity, contributes obesity, which promotes lipid accumulation liver. Recent studies underscore role impaired MASLD. Food including preservatives, emulsifiers, sweeteners, affect gut health function. Selected preservatives inhibit pathogenic microorganisms but disrupt microbiota, leading changes permeability dysfunction. Some emulsifiers thickeners can cause inflammation alter microbiome, contributing steatosis. Furthermore, use sweeteners such sucralose aspartame has been linked metabolism microbial composition, turn disorders.

Язык: Английский

Процитировано

1
Association of prebiotic/probiotic intake with MASLD: evidence from NHANES and randomized controlled trials in the context of prediction, prevention, and a personalized medicine framework DOI
Senlin Wang, Ruimin Zhang, Peisen Guo

и другие.

The EPMA Journal, Год журнала: 2025, Номер unknown

Опубликована: Янв. 29, 2025

Язык: Английский

Процитировано

1
Annual cycle variations in the gut microbiota of migratory black-necked cranes DOI Creative Commons

Yujia Zhang,

Ruifeng Ma,

Suolangduoerji

и другие.

Frontiers in Microbiology, Год журнала: 2025, Номер 16

Опубликована: Фев. 7, 2025

Migratory birds exhibit unique annual cycles that complicate their gut microbiota. However, the dynamics of microbiota in migratory remain unclear, hindering our understanding environmental adaptation. Here, we collected fecal samples from black-necked cranes (Grus nigricollis) across four seasons at breeding grounds and used wintering ground data databases to characterize microbial compositions throughout year. The results showed was clustered by season (Bray-Curtis: R 2 = 0.348, p < 0.001; UniFrac: 0.352, 0.001). And summer exhibited higher alpha (Simpson Shannon), beta diversity (Bray-Curtis UniFrac) more diverse functions compared other seasons. Furthermore, summer, several balanced relative abundances family level, whereas Lactobacillaceae dominated during Thirty-six ASVs were identified random forest analysis distinguish distinct Despite having greater diversity, had a simpler network structure than (fewer edges nodes). dispersal limitation processes also significantly influenced community assembly. Overall, crane undergoes dynamic adjustments adapt seasonal changes, which may be associated with variations diet These enhance wild support further research on cranes.

Язык: Английский

Процитировано

1
Lactobacillus sp. for the Attenuation of Metabolic Dysfunction-Associated Steatotic Liver Disease in Mice DOI Creative Commons
Titilayo Olotu, Jessica M. Ferrell

Microorganisms, Год журнала: 2024, Номер 12(12), С. 2488 - 2488

Опубликована: Дек. 3, 2024

Probiotics are studied for their therapeutic potential in the treatment of several diseases, including metabolic dysfunction-associated steatotic liver disease (MASLD). Part significant progress made understanding pathogenesis steatosis has come from identifying complex interplay between gut microbiome and function. Recently, probiotics have shown beneficial effects prevention MASLD rodent models clinical trials. Numerous studies demonstrated promising lactic acid bacteria, especially genus Lactobacillus. Lactobacillus is a prominent bile hydrolase bacterium that involved biotransformation acids. This genus’ modulation microbiota also contributes to overall health; it controls microbial overgrowth, shapes intestinal pool, alleviates inflammation. narrative review offers comprehensive summary gut-liver axis attenuate MASLD. It highlights roles hepatic lipid metabolism, insulin resistance, inflammation fibrosis, synthesis attenuating

Язык: Английский

Процитировано

0