bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Фев. 28, 2024
Abstract
Objective
Brain
oscillations,
broadband
1
/f
activity
and
neuronal
avalanches
(NA)
are
valuable
conceptualizations
extensively
used
to
interpret
brain
data,
yet,
these
perspectives
have
mainly
progressed
in
parallel
with
no
current
consensus
on
a
rationale
linking
them.
This
study
aims
reconcile
viewpoints
using
source-reconstructed
MEG
data
obtained
healthy
humans
during
eyes-closed
resting
state.
Methods
We
analyzed
NA
from
47
subjects.
For
this,
we
introduced
custom
measures
comprehensive
array
of
features
characterizing
the
statistical,
spatiotemporal
spectral
properties
NA.
By
complex
baseband
representation
signals
provide
an
analytical
description
mechanisms
underlying
emergence
Fourier
constituents
activity.
Results
The
observed
disclose
significant
signature
alpha
band,
suggesting
that
large-scale
spreading
bursts
occurs
via
avalanches.
Besides,
detected
our
dataset
can
be
segregated
based
their
two
main
groups
having
different
propagation
patterns,
where
cluster
2
is
related
spread
narrowband
across
network,
whereas
correspond
more
spatially
localized
fluctuations
promoted
by
also
framework
for
evidence
showing
a)
group
delay
consistency
specific
narrow
frequency
bands,
b)
transient
cross-regional
coherent
oscillations
c)
activity,
all
key
ingredients
realistic
Significance
proposed
arguments,
supported
extensive
model
experimental
evidence,
show
how
emerge
broad-band
arrhythmic
co-existing
human
brain.
Our
results
suggest
takes
place
manner
NA,
which
may
play
functional
role
as
long-range
interaction
mechanism
Highlights
Neuronal
propagating
spontaneous
state
highly
structured
terms
spatial,
temporal
properties.
link
between
local
above-threshold
understood
components
(spectral
consistency).
Spectral
consistency,
Observed
specifically
Large-scale
avalanches,
Non-human
animal
models
have
indicated
that
the
ratio
of
excitation
to
inhibition
(E/I)
in
neural
circuits
is
experience
dependent,
and
changes
across
development.
Here,
we
assessed
3T
Magnetic
Resonance
Spectroscopy
(MRS)
electroencephalography
(EEG)
markers
cortical
E/I
ten
individuals
who
had
been
treated
for
dense
bilateral
congenital
cataracts,
after
an
average
12
years
blindness,
test
dependence
on
early
visual
experience.
First,
participants
underwent
MRS
scanning
at
rest
with
their
eyes
opened
closed,
obtain
cortex
Gamma-Aminobutyric
Acid
(GABA+)
concentration,
Glutamate/Glutamine
(Glx)
concentration
Glx/GABA+,
as
measures
inhibition,
excitation,
respectively.
Subsequently,
EEG
was
recorded
assess
aperiodic
activity
(1-20
Hz)
a
neurophysiological
measure
ratio,
during
open
flickering
stimulation.
Across
conditions,
sight
recovery
demonstrated
significantly
lower
Glx/GABA+
higher
intercept
steeper
slope
occipital
electrodes,
compared
age-matched
sighted
controls.
In
group,
associated
better
acuity,
Glx
correlated
positively
conditions
input.
We
interpret
these
findings
resulting
from
increased
consequence
which
required
commensurately
restored
input
provided
additional
excitation.
Non-human
animal
models
have
indicated
that
the
ratio
of
excitation
to
inhibition
(E/I)
in
neural
circuits
is
experience
dependent
and
changes
across
development.
Here,
we
assessed
3T
Magnetic
Resonance
Spectroscopy
(MRS)
electroencephalography
(EEG)
markers
cortical
E/I
ten
individuals
who
had
been
treated
for
dense
bilateral
congenital
cataracts,
after
an
average
12
years
blindness,
test
dependence
humans
on
early
visual
experience.
First,
participants
underwent
MRS
scanning
at
rest
with
their
eyes
opened
closed,
obtain
cortex
Gamma-Aminobutyric
Acid
(GABA+)
concentration,
Glutamate/Glutamine
(Glx)
concentration
Glx/GABA+,
as
measures
inhibition,
excitation,
respectively.
Subsequently,
EEG
was
recorded
assess
aperiodic
activity
(1-20
Hz)
a
neurophysiological
measure
ratio,
during
open
flickering
stimulation.
Across
conditions,
cataract-reversal
demonstrated
significantly
lower
Glx/GABA+
higher
intercept
steeper
slope
occipital
electrodes,
compared
age-matched
sighted
controls.
In
group,
associated
better
acuity,
Glx
correlated
positively
conditions
input.
We
speculate
these
findings
result
from
increased
consequence
which
might
require
commensurately
order
balance
additional
restored
The
would
thus
be
homeostatic
plasticity.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 6, 2024
Abstract
Although
the
primary
function
of
excitatory-inhibitory
(E-I)
homeostasis
is
maintenance
mean
firing
rates,
conjugation
multiple
homeostatic
mechanisms
thought
to
be
pivotal
ensuring
edge-of-bifurcation
dynamics
in
cortical
circuits.
However,
computational
studies
on
E-I
have
focused
solely
plasticity
inhibition,
neglecting
impact
different
modes
dynamics.
Therefore,
we
investigate
how
oscillations
and
are
shaped
by
diverse
employed
networks.
Using
Wilson-Cowan
model,
explore
distinct
maintain
stable
rates
models
with
varying
levels
input
it
affects
circuit
Our
results
confirm
that
can
leveraged
control
some
under
higher
modulating
distance
bifurcation.
Additionally,
relying
ensures
activity
while
keeping
oscillation
frequencies
within
a
physiological
range.
findings
tie
relevant
features
networks,
such
as
balance,
generation
gamma
oscillations,
dynamics,
framework
firing-rate
homeostasis,
providing
mechanistic
explanation
for
heterogeneity
bifurcation
found
across
areas.
In
addition,
reveal
functional
benefits
upon
mechanisms,
robust
method
regulate
network
minimal
perturbation
rhythms
explaining
correlation
between
inhibition
Author
summary
We
study
controls
networks
impacts
oscillations.
Importantly,
previous
limited
wide
range
and,
more
importantly,
they
interact.
Here,
derive
mathematical
solution
model
shape
That
said,
demonstrate
particularly
excitation
intrinsic
excitability,
modulates
relative
damped
sustained
manner
previously
unaccounted
for,
mechanism
implementation
heterogeneous
distances
Furthermore,
our
stress
allowing
remain
relationship
empirical
data.
With
these
results,
unify
lens
homeostasis.
Genuinely
new
discovery
transcends
existing
knowledge.
Despite
this,
many
analyses
in
systems
neuroscience
neglect
to
test
speculative
hypotheses
against
benchmark
empirical
facts.
Some
of
these
inadvertently
use
circular
reasoning
present
knowledge
as
discovery.
Here,
I
discuss
that
this
problem
can
confound
key
results
and
estimate
it
has
affected
more
than
three
thousand
studies
network
over
the
last
decade.
suggest
future
reduce
by
limiting
evidence,
integrating
into
models,
rigorously
testing
proposed
discoveries
models.
conclude
with
a
summary
practical
challenges
recommendations.
Entropy,
Год журнала:
2023,
Номер
25(7), С. 1074 - 1074
Опубликована: Июль 17, 2023
Time
and
space
are
fundamental
elements
that
permeate
the
fabric
of
nature,
their
significance
in
relation
to
neural
activity
consciousness
remains
a
compelling
yet
unexplored
area
research.
The
Temporospatial
Theory
Consciousness
(TTC)
provides
framework
links
time,
space,
activity,
consciousness,
shedding
light
on
intricate
relationships
among
these
dimensions.
In
this
review,
I
revisit
concepts
mechanisms
proposed
by
TTC,
with
particular
focus
central
concept
temporospatial
nestedness.
propose
an
extension
nestedness
incorporating
nested
relationship
between
temporal
circuit
functional
geometry
brain.
To
further
unravel
complexities
nestedness,
future
research
directions
should
emphasize
characterization
across
multiple
spatial
scales.
Investigating
scales
will
yield
more
comprehensive
understanding
how
organization
dynamics
contribute
conscious
states.
This
integrative
approach
holds
potential
uncover
novel
insights
into
basis
reshape
our
world-brain
dynamic.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Апрель 22, 2024
ABSTRACT
Non-human
animal
models
have
indicated
that
the
ratio
of
excitation
to
inhibition
(E/I)
in
neural
circuits
is
experience
dependent
and
changes
across
development.
Here,
we
assessed
3T
Magnetic
Resonance
Spectroscopy
(MRS)
electroencephalography
(EEG)
markers
cortical
E/I
ten
individuals
who
had
been
treated
for
dense
bilateral
congenital
cataracts,
after
an
average
12
years
blindness,
test
dependence
humans
on
early
visual
experience.
First,
participants
underwent
MRS
scanning
at
rest
with
their
eyes
opened
closed,
obtain
cortex
Gamma-Aminobutyric
Acid
(GABA+)
concentration,
Glutamate/Glutamine
(Glx)
concentration
Glx/GABA+,
as
measures
inhibition,
excitation,
respectively.
Subsequently,
EEG
was
recorded
assess
aperiodic
activity
(1-20
Hz)
a
neurophysiological
measure
ratio,
during
open
flickering
stimulation.
Across
conditions,
cataract-reversal
demonstrated
significantly
lower
Glx/GABA+
higher
intercept
steeper
slope
occipital
electrodes,
compared
age-matched
sighted
controls.
In
group,
associated
better
acuity,
Glx
correlated
positively
conditions
input.
We
speculate
these
findings
result
from
increased
consequence
which
might
require
commensurately
order
balance
additional
restored
The
would
thus
be
homeostatic
plasticity.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Фев. 28, 2024
Abstract
Objective
Brain
oscillations,
broadband
1
/f
activity
and
neuronal
avalanches
(NA)
are
valuable
conceptualizations
extensively
used
to
interpret
brain
data,
yet,
these
perspectives
have
mainly
progressed
in
parallel
with
no
current
consensus
on
a
rationale
linking
them.
This
study
aims
reconcile
viewpoints
using
source-reconstructed
MEG
data
obtained
healthy
humans
during
eyes-closed
resting
state.
Methods
We
analyzed
NA
from
47
subjects.
For
this,
we
introduced
custom
measures
comprehensive
array
of
features
characterizing
the
statistical,
spatiotemporal
spectral
properties
NA.
By
complex
baseband
representation
signals
provide
an
analytical
description
mechanisms
underlying
emergence
Fourier
constituents
activity.
Results
The
observed
disclose
significant
signature
alpha
band,
suggesting
that
large-scale
spreading
bursts
occurs
via
avalanches.
Besides,
detected
our
dataset
can
be
segregated
based
their
two
main
groups
having
different
propagation
patterns,
where
cluster
2
is
related
spread
narrowband
across
network,
whereas
correspond
more
spatially
localized
fluctuations
promoted
by
also
framework
for
evidence
showing
a)
group
delay
consistency
specific
narrow
frequency
bands,
b)
transient
cross-regional
coherent
oscillations
c)
activity,
all
key
ingredients
realistic
Significance
proposed
arguments,
supported
extensive
model
experimental
evidence,
show
how
emerge
broad-band
arrhythmic
co-existing
human
brain.
Our
results
suggest
takes
place
manner
NA,
which
may
play
functional
role
as
long-range
interaction
mechanism
Highlights
Neuronal
propagating
spontaneous
state
highly
structured
terms
spatial,
temporal
properties.
link
between
local
above-threshold
understood
components
(spectral
consistency).
Spectral
consistency,
Observed
specifically
Large-scale
avalanches,
