Linking neuronal avalanches with oscillatory and broadband 1/factivities in the resting human brain DOI Creative Commons
Damián Dellavale, Giovanni Rabuffo, Emahnuel Troisi Lopez

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Фев. 28, 2024

Abstract Objective Brain oscillations, broadband 1 /f activity and neuronal avalanches (NA) are valuable conceptualizations extensively used to interpret brain data, yet, these perspectives have mainly progressed in parallel with no current consensus on a rationale linking them. This study aims reconcile viewpoints using source-reconstructed MEG data obtained healthy humans during eyes-closed resting state. Methods We analyzed NA from 47 subjects. For this, we introduced custom measures comprehensive array of features characterizing the statistical, spatiotemporal spectral properties NA. By complex baseband representation signals provide an analytical description mechanisms underlying emergence Fourier constituents activity. Results The observed disclose significant signature alpha band, suggesting that large-scale spreading bursts occurs via avalanches. Besides, detected our dataset can be segregated based their two main groups having different propagation patterns, where cluster 2 is related spread narrowband across network, whereas correspond more spatially localized fluctuations promoted by also framework for evidence showing a) group delay consistency specific narrow frequency bands, b) transient cross-regional coherent oscillations c) activity, all key ingredients realistic Significance proposed arguments, supported extensive model experimental evidence, show how emerge broad-band arrhythmic co-existing human brain. Our results suggest takes place manner NA, which may play functional role as long-range interaction mechanism Highlights Neuronal propagating spontaneous state highly structured terms spatial, temporal properties. link between local above-threshold understood components (spectral consistency). Spectral consistency, Observed specifically Large-scale avalanches,

Язык: Английский

EEG spectral attractors identify a geometric core of brain dynamics DOI Creative Commons

Parham Pourdavood,

Michael Jacob

Patterns, Год журнала: 2024, Номер 5(9), С. 101025 - 101025

Опубликована: Июль 19, 2024

Язык: Английский

Процитировано

2

Altered visual cortex excitatory/inhibitory ratio following transient congenital visual deprivation in humans DOI Open Access
Rashi Pant, Kabilan Pitchaimuthu, José Ossandón

и другие.

Опубликована: Июнь 5, 2024

Non-human animal models have indicated that the ratio of excitation to inhibition (E/I) in neural circuits is experience dependent, and changes across development. Here, we assessed 3T Magnetic Resonance Spectroscopy (MRS) electroencephalography (EEG) markers cortical E/I ten individuals who had been treated for dense bilateral congenital cataracts, after an average 12 years blindness, test dependence on early visual experience. First, participants underwent MRS scanning at rest with their eyes opened closed, obtain cortex Gamma-Aminobutyric Acid (GABA+) concentration, Glutamate/Glutamine (Glx) concentration Glx/GABA+, as measures inhibition, excitation, respectively. Subsequently, EEG was recorded assess aperiodic activity (1-20 Hz) a neurophysiological measure ratio, during open flickering stimulation. Across conditions, sight recovery demonstrated significantly lower Glx/GABA+ higher intercept steeper slope occipital electrodes, compared age-matched sighted controls. In group, associated better acuity, Glx correlated positively conditions input. We interpret these findings resulting from increased consequence which required commensurately restored input provided additional excitation.

Язык: Английский

Процитировано

1

Altered visual cortex excitatory/inhibitory ratio following transient congenital visual deprivation in humans DOI Creative Commons
Rashi Pant, Kabilan Pitchaimuthu, José Ossandón

и другие.

eLife, Год журнала: 2024, Номер unknown

Опубликована: Июнь 5, 2024

Non-human animal models have indicated that the ratio of excitation to inhibition (E/I) in neural circuits is experience dependent and changes across development. Here, we assessed 3T Magnetic Resonance Spectroscopy (MRS) electroencephalography (EEG) markers cortical E/I ten individuals who had been treated for dense bilateral congenital cataracts, after an average 12 years blindness, test dependence humans on early visual experience. First, participants underwent MRS scanning at rest with their eyes opened closed, obtain cortex Gamma-Aminobutyric Acid (GABA+) concentration, Glutamate/Glutamine (Glx) concentration Glx/GABA+, as measures inhibition, excitation, respectively. Subsequently, EEG was recorded assess aperiodic activity (1-20 Hz) a neurophysiological measure ratio, during open flickering stimulation. Across conditions, cataract-reversal demonstrated significantly lower Glx/GABA+ higher intercept steeper slope occipital electrodes, compared age-matched sighted controls. In group, associated better acuity, Glx correlated positively conditions input. We speculate these findings result from increased consequence which might require commensurately order balance additional restored The would thus be homeostatic plasticity.

Язык: Английский

Процитировано

1

Excitatory-Inhibitory Homeostasis and Bifurcation Control in the Wilson-Cowan Model of Cortical Dynamics DOI Creative Commons
Francisco Páscoa dos Santos, Paul F. M. J. Verschure

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июнь 6, 2024

Abstract Although the primary function of excitatory-inhibitory (E-I) homeostasis is maintenance mean firing rates, conjugation multiple homeostatic mechanisms thought to be pivotal ensuring edge-of-bifurcation dynamics in cortical circuits. However, computational studies on E-I have focused solely plasticity inhibition, neglecting impact different modes dynamics. Therefore, we investigate how oscillations and are shaped by diverse employed networks. Using Wilson-Cowan model, explore distinct maintain stable rates models with varying levels input it affects circuit Our results confirm that can leveraged control some under higher modulating distance bifurcation. Additionally, relying ensures activity while keeping oscillation frequencies within a physiological range. findings tie relevant features networks, such as balance, generation gamma oscillations, dynamics, framework firing-rate homeostasis, providing mechanistic explanation for heterogeneity bifurcation found across areas. In addition, reveal functional benefits upon mechanisms, robust method regulate network minimal perturbation rhythms explaining correlation between inhibition Author summary We study controls networks impacts oscillations. Importantly, previous limited wide range and, more importantly, they interact. Here, derive mathematical solution model shape That said, demonstrate particularly excitation intrinsic excitability, modulates relative damped sustained manner previously unaccounted for, mechanism implementation heterogeneous distances Furthermore, our stress allowing remain relationship empirical data. With these results, unify lens homeostasis.

Язык: Английский

Процитировано

1

Behavioral measurement of interhemispheric interactions during multiple episodes of falling asleep DOI
Alexander E. Manaenkov, N. O. Prokhorenko,

Dmitri S. Sveshnikov

и другие.

The European Physical Journal Special Topics, Год журнала: 2023, Номер 233(3), С. 615 - 629

Опубликована: Дек. 6, 2023

Язык: Английский

Процитировано

3

Circular and unified analysis in network neuroscience DOI Open Access
Mikail Rubinov

Опубликована: Апрель 11, 2022

Genuinely new discovery transcends existing knowledge. Despite this, many analyses in systems neuroscience neglect to test speculative hypotheses against benchmark empirical facts. Some of these inadvertently use circular reasoning present knowledge as discovery. Here, I discuss that this problem can confound key results and estimate it has affected more than three thousand studies network over the last decade. suggest future reduce by limiting evidence, integrating into models, rigorously testing proposed discoveries models. conclude with a summary practical challenges recommendations.

Язык: Английский

Процитировано

5

Temporospatial Nestedness in Consciousness: An Updated Perspective on the Temporospatial Theory of Consciousness DOI Creative Commons
Zirui Huang

Entropy, Год журнала: 2023, Номер 25(7), С. 1074 - 1074

Опубликована: Июль 17, 2023

Time and space are fundamental elements that permeate the fabric of nature, their significance in relation to neural activity consciousness remains a compelling yet unexplored area research. The Temporospatial Theory Consciousness (TTC) provides framework links time, space, activity, consciousness, shedding light on intricate relationships among these dimensions. In this review, I revisit concepts mechanisms proposed by TTC, with particular focus central concept temporospatial nestedness. propose an extension nestedness incorporating nested relationship between temporal circuit functional geometry brain. To further unravel complexities nestedness, future research directions should emphasize characterization across multiple spatial scales. Investigating scales will yield more comprehensive understanding how organization dynamics contribute conscious states. This integrative approach holds potential uncover novel insights into basis reshape our world-brain dynamic.

Язык: Английский

Процитировано

2

Altered visual cortex excitatory/inhibitory ratio following transient congenital visual deprivation in humans DOI Creative Commons
Rashi Pant, Kabilan Pitchaimuthu, José Ossandón

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Апрель 22, 2024

ABSTRACT Non-human animal models have indicated that the ratio of excitation to inhibition (E/I) in neural circuits is experience dependent and changes across development. Here, we assessed 3T Magnetic Resonance Spectroscopy (MRS) electroencephalography (EEG) markers cortical E/I ten individuals who had been treated for dense bilateral congenital cataracts, after an average 12 years blindness, test dependence humans on early visual experience. First, participants underwent MRS scanning at rest with their eyes opened closed, obtain cortex Gamma-Aminobutyric Acid (GABA+) concentration, Glutamate/Glutamine (Glx) concentration Glx/GABA+, as measures inhibition, excitation, respectively. Subsequently, EEG was recorded assess aperiodic activity (1-20 Hz) a neurophysiological measure ratio, during open flickering stimulation. Across conditions, cataract-reversal demonstrated significantly lower Glx/GABA+ higher intercept steeper slope occipital electrodes, compared age-matched sighted controls. In group, associated better acuity, Glx correlated positively conditions input. We speculate these findings result from increased consequence which might require commensurately order balance additional restored The would thus be homeostatic plasticity.

Язык: Английский

Процитировано

0

Linking neuronal avalanches with oscillatory and broadband 1/factivities in the resting human brain DOI Creative Commons
Damián Dellavale, Giovanni Rabuffo, Emahnuel Troisi Lopez

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Фев. 28, 2024

Abstract Objective Brain oscillations, broadband 1 /f activity and neuronal avalanches (NA) are valuable conceptualizations extensively used to interpret brain data, yet, these perspectives have mainly progressed in parallel with no current consensus on a rationale linking them. This study aims reconcile viewpoints using source-reconstructed MEG data obtained healthy humans during eyes-closed resting state. Methods We analyzed NA from 47 subjects. For this, we introduced custom measures comprehensive array of features characterizing the statistical, spatiotemporal spectral properties NA. By complex baseband representation signals provide an analytical description mechanisms underlying emergence Fourier constituents activity. Results The observed disclose significant signature alpha band, suggesting that large-scale spreading bursts occurs via avalanches. Besides, detected our dataset can be segregated based their two main groups having different propagation patterns, where cluster 2 is related spread narrowband across network, whereas correspond more spatially localized fluctuations promoted by also framework for evidence showing a) group delay consistency specific narrow frequency bands, b) transient cross-regional coherent oscillations c) activity, all key ingredients realistic Significance proposed arguments, supported extensive model experimental evidence, show how emerge broad-band arrhythmic co-existing human brain. Our results suggest takes place manner NA, which may play functional role as long-range interaction mechanism Highlights Neuronal propagating spontaneous state highly structured terms spatial, temporal properties. link between local above-threshold understood components (spectral consistency). Spectral consistency, Observed specifically Large-scale avalanches,

Язык: Английский

Процитировано

0