Aging and Disease,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
Endogenous
retroviruses
(ERVs),
a
subset
of
genomic
transposable
elements
(TEs)
in
broader
sense,
have
remained
latent
within
mammalian
genomes
for
tens
millions
years.
These
genetic
are
typically
silenced
state
due
to
stringent
regulatory
mechanisms.
However,
under
specific
conditions,
they
can
become
activated,
triggering
inflammatory
responses
through
diverse
This
activation
has
been
shown
play
potential
role
various
neurological
disorders,
tumors,
and
cellular
senescence.
Consequently,
the
regulation
ERV
expression
methods
holds
promise
clinical
applications
disease
treatment.
ERVs
also
engage
interactions
with
variety
exogenous
viruses,
thereby
influencing
outcomes
viral
infectious
diseases.
article
comprehensively
reviews
pathogenic
cascade
ERVs,
encompassing
activation,
inflammation,
associated
diseases,
senescence,
interplay
viruses.
Additionally,
it
outlines
therapeutic
strategies
targeting
aim
offering
novel
research
directions
understanding
relationship
between
along
corresponding
treatment
modalities.
Phase
separation,
a
biophysical
segregation
of
subcellular
milieus
referred
as
condensates,
is
known
to
regulate
transcription,
but
its
impacts
on
physiological
processes
are
less
clear.
Here,
we
demonstrate
the
formation
liquid-like
nuclear
condensates
by
SGF29,
component
SAGA
transcriptional
coactivator
complex,
during
cellular
senescence
in
human
mesenchymal
progenitor
cells
(hMPCs)
and
fibroblasts.
The
Arg
207
within
intrinsically
disordered
region
identified
key
amino
acid
residue
for
SGF29
form
phase
separation.
Through
epigenomic
transcriptomic
analysis,
our
data
indicated
that
both
condensate
H3K4me3
binding
essential
establishing
precise
chromatin
location,
recruiting
factors
co-activators
target
specific
genomic
loci,
initiating
expression
genes
associated
with
senescence,
such
CDKN1A.
alone,
however,
may
not
be
sufficient
drive
or
achieve
transactivation
functions.
Our
study
establishes
link
between
separation
aging
regulation,
highlighting
functional
unit
facilitate
shaping
landscapes
aging.
Protein & Cell,
Год журнала:
2024,
Номер
15(8), С. 612 - 632
Опубликована: Апрель 5, 2024
Abstract
Aging
has
a
profound
impact
on
the
gingiva
and
significantly
increases
its
susceptibility
to
periodontitis,
worldwide
prevalent
inflammatory
disease.
However,
systematic
characterization
comprehensive
understanding
of
regulatory
mechanism
underlying
gingival
aging
is
still
lacking.
Here,
we
systematically
dissected
phenotypic
characteristics
during
in
primates
constructed
first
single-nucleus
transcriptomic
landscape
aging,
by
which
panel
cell
type-specific
signatures
were
elucidated.
Epithelial
cells
identified
as
most
affected
types
gingiva.
Further
analyses
pinpointed
crucial
role
YAP
epithelial
self-renew
homeostasis,
declined
cells,
especially
basal
cells.
The
decline
activity
was
confirmed
human
tissues,
downregulation
primary
keratinocytes
recapitulated
major
defects
observed
aged
primate
while
overexpression
showed
rejuvenation
effects.
Our
work
provides
an
in-depth
serves
rich
resource
for
developing
novel
strategies
combat
aging-associated
diseases,
with
ultimate
goal
advancing
periodontal
health
promoting
healthy
aging.
Abstract
Reactivation
of
retroelements
in
the
human
genome
has
been
linked
to
aging.
However,
whether
epigenetic
state
specific
can
predict
chronological
age
remains
unknown.
We
provide
evidence
that
locus‐specific
retroelement
DNA
methylation
be
used
create
retroelement‐based
clocks
accurately
measure
immune
system,
across
tissues,
and
pan‐mammalian
species.
also
developed
a
highly
accurate
clock
compatible
with
EPICv.2.0
data
was
constructed
from
CpGs
did
not
overlap
existing
first‐
second‐generation
clocks,
suggesting
unique
signal
for
previously
captured.
found
were
reversed
during
transient
reprogramming,
accelerated
people
living
HIV‐1,
responsive
antiretroviral
therapy.
Our
findings
highlight
utility
biomarkers
aging
support
renewed
emphasis
on
role
geroscience.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(8), С. 4443 - 4443
Опубликована: Апрель 18, 2024
Brain
aging
causes
a
wide
variety
of
changes
at
the
molecular
and
cellular
levels,
leading
to
decline
cognitive
functions
increased
vulnerability
neurodegenerative
disorders.
The
research
aimed
understanding
brain
has
made
much
progress
in
recent
decades.
Technological
innovations
such
as
single-cell
RNA-sequencing
(scRNA-seq),
proteomic
analyses,
spatial
transcriptomic
analyses
have
facilitated
on
dynamic
occurring
within
neurons,
glia,
other
cells
along
with
their
impacts
intercellular
communication
during
aging.
In
this
review,
we
introduce
trends
how
neurons
glia
change
discuss
impact
microenvironment
blood-brain
barrier
(BBB).
