Causal relationship between multiparameter brain MRI phenotypes and age: evidence from Mendelian randomization DOI Creative Commons
Xinghao Wang, Qian Chen, Yawen Liu

и другие.

Brain Communications, Год журнала: 2024, Номер 6(2)

Опубликована: Янв. 1, 2024

Abstract To explore the causal relationship between age and brain health (cortical atrophy, white matter integrity, hyperintensities cerebral microbleeds in various regions) related multiparameter imaging features using two-sample Mendelian randomization. Age was determined as chronological of subject. Cortical volume, micro-integrity, hyperintensity volume each region were included phenotypes for health. genetic data analysed to determine inverse-variance weighted model, validated by heterogeneity horizontal pleiotropy variables. is causally increased volumes (β = 0.151). For fibres inferior cerebellar peduncle (axial diffusivity β −0.128, orientation dispersion index 0.173), −0.136), superior fronto-occipital fasciculus (isotropic fraction 0.163) within limbic system deteriorated. We also detected decreased cortical thickness multiple frontal temporal regions (P < 0.05). Microbleeds not with aging > Aging a threat health, leading atrophy mainly lobes, well degeneration especially abnormal deteriorated integrity around hippocampus.

Язык: Английский

Activation of human endogenous retroviruses and its physiological consequences DOI
Nicholas Dopkins, Douglas F. Nixon

Nature Reviews Molecular Cell Biology, Год журнала: 2023, Номер 25(3), С. 212 - 222

Опубликована: Окт. 23, 2023

Язык: Английский

Процитировано

57

Stress, epigenetics, and aging: Unraveling the intricate crosstalk DOI Creative Commons
Zeming Wu, Jing Qu, Weiqi Zhang

и другие.

Molecular Cell, Год журнала: 2023, Номер 84(1), С. 34 - 54

Опубликована: Ноя. 13, 2023

Язык: Английский

Процитировано

55

Metformin decelerates aging clock in male monkeys DOI
Yuan‐Han Yang,

Xiaoyong Lu,

Ning Liu

и другие.

Cell, Год журнала: 2024, Номер 187(22), С. 6358 - 6378.e29

Опубликована: Сен. 12, 2024

Язык: Английский

Процитировано

54

CHIT1-positive microglia drive motor neuron ageing in the primate spinal cord DOI
Shuhui Sun, Jiaming Li, Si Wang

и другие.

Nature, Год журнала: 2023, Номер 624(7992), С. 611 - 620

Опубликована: Окт. 31, 2023

Язык: Английский

Процитировано

41

Roles of chromatin and genome instability in cellular senescence and their relevance to ageing and related diseases DOI
Zeming Wu, Jing Qu, Guang‐Hui Liu

и другие.

Nature Reviews Molecular Cell Biology, Год журнала: 2024, Номер 25(12), С. 979 - 1000

Опубликована: Окт. 3, 2024

Язык: Английский

Процитировано

15

SIRT5 safeguards against primate skeletal muscle ageing via desuccinylation of TBK1 DOI
Qian Zhao, Ying Jing, Xiaoyu Jiang

и другие.

Nature Metabolism, Год журнала: 2025, Номер unknown

Опубликована: Март 14, 2025

Язык: Английский

Процитировано

2

SGF29 nuclear condensates reinforce cellular aging DOI Creative Commons
Kaowen Yan, Qianzhao Ji, Dongxin Zhao

и другие.

Cell Discovery, Год журнала: 2023, Номер 9(1)

Опубликована: Ноя. 7, 2023

Phase separation, a biophysical segregation of subcellular milieus referred as condensates, is known to regulate transcription, but its impacts on physiological processes are less clear. Here, we demonstrate the formation liquid-like nuclear condensates by SGF29, component SAGA transcriptional coactivator complex, during cellular senescence in human mesenchymal progenitor cells (hMPCs) and fibroblasts. The Arg 207 within intrinsically disordered region identified key amino acid residue for SGF29 form phase separation. Through epigenomic transcriptomic analysis, our data indicated that both condensate H3K4me3 binding essential establishing precise chromatin location, recruiting factors co-activators target specific genomic loci, initiating expression genes associated with senescence, such CDKN1A. alone, however, may not be sufficient drive or achieve transactivation functions. Our study establishes link between separation aging regulation, highlighting functional unit facilitate shaping landscapes aging.

Язык: Английский

Процитировано

19

Single-nucleus transcriptomics uncovers a geroprotective role of YAP in primate gingival aging DOI Creative Commons
Qinchao Hu, Bin Zhang,

Yaobin Jing

и другие.

Protein & Cell, Год журнала: 2024, Номер 15(8), С. 612 - 632

Опубликована: Апрель 5, 2024

Abstract Aging has a profound impact on the gingiva and significantly increases its susceptibility to periodontitis, worldwide prevalent inflammatory disease. However, systematic characterization comprehensive understanding of regulatory mechanism underlying gingival aging is still lacking. Here, we systematically dissected phenotypic characteristics during in primates constructed first single-nucleus transcriptomic landscape aging, by which panel cell type-specific signatures were elucidated. Epithelial cells identified as most affected types gingiva. Further analyses pinpointed crucial role YAP epithelial self-renew homeostasis, declined cells, especially basal cells. The decline activity was confirmed human tissues, downregulation primary keratinocytes recapitulated major defects observed aged primate while overexpression showed rejuvenation effects. Our work provides an in-depth serves rich resource for developing novel strategies combat aging-associated diseases, with ultimate goal advancing periodontal health promoting healthy aging.

Язык: Английский

Процитировано

7

Retro‐age: A unique epigenetic biomarker of aging captured by DNA methylation states of retroelements DOI Creative Commons
Lishomwa C. Ndhlovu, Matthew L. Bendall, Varun B. Dwaraka

и другие.

Aging Cell, Год журнала: 2024, Номер 23(10)

Опубликована: Авг. 2, 2024

Abstract Reactivation of retroelements in the human genome has been linked to aging. However, whether epigenetic state specific can predict chronological age remains unknown. We provide evidence that locus‐specific retroelement DNA methylation be used create retroelement‐based clocks accurately measure immune system, across tissues, and pan‐mammalian species. also developed a highly accurate clock compatible with EPICv.2.0 data was constructed from CpGs did not overlap existing first‐ second‐generation clocks, suggesting unique signal for previously captured. found were reversed during transient reprogramming, accelerated people living HIV‐1, responsive antiretroviral therapy. Our findings highlight utility biomarkers aging support renewed emphasis on role geroscience.

Язык: Английский

Процитировано

6

Neuronal cathepsin S increases neuroinflammation and causes cognitive decline via CX3CL1‐CX3CR1 axis and JAK2‐STAT3 pathway in aging and Alzheimer's disease DOI Creative Commons

Peipei Liu,

Xiaohui Liu,

Mingjing Ren

и другие.

Aging Cell, Год журнала: 2024, Номер unknown

Опубликована: Окт. 25, 2024

Abstract Aging is an intricate process involving interactions among multiple factors, which one of the main risks for chronic diseases, including Alzheimer's disease (AD). As a member cysteine protease, cathepsin S (CTSS) has been implicated in inflammation across various diseases. Here, we investigated role neuronal CTSS aging and AD started by examining expression hippocampus neurons mice identified significant increase, was negatively correlated with recognition abilities. Concurrently, observed elevation concentration serum elderly people. Transcriptome fluorescence‐activated cell sorting (FACS) results revealed that overexpression aggravated brain inflammatory milieu microglia activation to M1 pro‐inflammatory phenotype, chemokine C‐X3‐C‐motif ligand 1 (CX3CL1)—chemokine receptor (CX3CR1) axis janus kinase 2 (JAK2)—signal transducer activator transcription 3 (STAT3) pathway. CX3CL1 secreted acts on CX3CR1 microglia, our first time neuron neuron–microglia “crosstalk.” Besides, elevated regions patients, hippocampus. Utilizing selective inhibitor, LY3000328, rescued AD‐related pathological features APP/PS1 mice. We further noticed increased B (CTSB) activity, but decreased L (CTSL) activity microglia. Overall, provide evidence can be used as biomarker plays regulatory roles through modulating neuroinflammation process.

Язык: Английский

Процитировано

6