Sensory input, sex and function shape hypothalamic cell type development
Nature,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 5, 2025
Язык: Английский
Sensory Input, Sex, and Function Shape Hypothalamic Cell Type Development
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 23, 2024
Abstract
Mammalian
behavior
and
physiology
undergo
dramatic
changes
in
early
life.
Young
animals
rely
on
conspecifics
to
meet
their
homeostatic
needs,
until
weaning
puberty
initiate
nutritional
independence
sex-specific
social
interactions,
respectively.
How
neuronal
populations
regulating
functions
behaviors
develop
mature
during
these
transitions
remains
unclear.
We
used
paired
transcriptomic
chromatin
accessibility
profiling
examine
the
developmental
trajectories
of
hypothalamic
preoptic
region,
where
cell
types
with
key
roles
physiological
behavioral
control
have
been
identified
1–6
.
These
data
reveal
a
remarkable
diversity
shaped
by
sex
animal,
location
or
function
corresponding
types.
identify
stages
development,
including
perinatal
emergence
differences,
postnatal
maturation
subsequent
refinement
signaling
networks,
nonlinear
transcriptional
accelerating
at
time
puberty.
assessed
development
various
sensory
mutants
find
major
role
for
vomeronasal
sensing
timing
type
maturation.
results
provide
novel
insights
into
neurons
controlling
lay
ground
examining
dynamics
Язык: Английский
Conjoint specification of action by neocortex and striatum
Neuron,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Coincident development and synchronization of sleep-dependent delta in the cortex and medulla
Current Biology,
Год журнала:
2024,
Номер
34(12), С. 2570 - 2579.e5
Опубликована: Май 20, 2024
Язык: Английский
More Than a Small Brain: The Importance of Studying Neural Function during Development
Journal of Neuroscience,
Год журнала:
2024,
Номер
44(48), С. e1367242024 - e1367242024
Опубликована: Ноя. 27, 2024
The
nervous
system
contains
complex
circuits
comprising
thousands
of
cell
types
and
trillions
connections.
Here,
we
discuss
how
the
field
“developmental
systems
neuroscience”
combines
molecular
genetic
perspectives
developmental
neuroscience
with
(typically
adult-focused)
functional
perspective
neuroscience.
This
combination
approaches
is
critical
to
understanding
a
handful
cells
eventually
produce
wide
range
behaviors
necessary
for
survival.
Functional
circuit
development
typically
lags
behind
neural
connectivity,
leading
intermediate
stages
activity
that
are
either
not
seen
in
adults
or,
if
present,
considered
pathophysiological.
Developmental
examines
these
activity,
mapping
out
phases
inflection
points
function
understand
behavior
emerge
across
development.
Beyond
typical
development,
this
approach
provides
invaluable
insight
into
pathophysiology
neurodevelopmental
disorders
by
identifying
when
diverges
between
health
disease.
We
argue
will
identify
important
periods
reveal
novel
therapeutic
windows
treatment,
set
stage
answer
fundamental
questions
about
brain
Язык: Английский
“Cortical Delta” in the Medulla of Sleeping Infant Rats
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Дек. 17, 2023
Summary
In
early
development,
active
sleep
is
the
predominant
state
before
it
supplanted
by
quiet
sleep.
rats,
developmental
increase
in
accompanied
sudden
emergence
of
cortical
delta
rhythm
(0.5-4
Hz)
around
postnatal
day
12
(P12).
We
sought
to
explain
assessing
changes
activity
parafacial
zone
(PZ),
a
medullary
structure
thought
regulate
adults.
recorded
from
PZ
P10
and
P12
rats
predicted
an
age-related
neural
during
increasing
periods
delta-rich
activity.
Instead,
we
discovered
sleep-dependent
rhythmic
spiking
activity—with
intervening
total
silence—phase-locked
local
rhythm.
Moreover,
were
coherent
at
P12,
but
not
P10.
was
also
phase-locked
respiration,
suggesting
modulation
respiratory
pacemakers
ventral
medulla.
Disconnecting
main
olfactory
bulbs
cortex
did
diminish
delta,
indicating
that
influence
respiration
on
this
age
mediated
indirectly
through
nasal
breathing.
Finally,
observed
parvalbumin-expressing
terminals
across
these
ages,
supporting
role
for
GABAergic
inhibition
PZ’s
rhythmicity.
The
discovery
delta-rhythmic
medulla—when
emerging—opens
new
path
understanding
brainstem’s
regulating
synchronizing
throughout
brain.
Язык: Английский