“Cortical Delta” in the Medulla of Sleeping Infant Rats DOI Creative Commons
Midha Ahmad,

Jangjin Kim,

Brett Dwyer

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 17, 2023

Summary In early development, active sleep is the predominant state before it supplanted by quiet sleep. rats, developmental increase in accompanied sudden emergence of cortical delta rhythm (0.5-4 Hz) around postnatal day 12 (P12). We sought to explain assessing changes activity parafacial zone (PZ), a medullary structure thought regulate adults. recorded from PZ P10 and P12 rats predicted an age-related neural during increasing periods delta-rich activity. Instead, we discovered sleep-dependent rhythmic spiking activity—with intervening total silence—phase-locked local rhythm. Moreover, were coherent at P12, but not P10. was also phase-locked respiration, suggesting modulation respiratory pacemakers ventral medulla. Disconnecting main olfactory bulbs cortex did diminish delta, indicating that influence respiration on this age mediated indirectly through nasal breathing. Finally, observed parvalbumin-expressing terminals across these ages, supporting role for GABAergic inhibition PZ’s rhythmicity. The discovery delta-rhythmic medulla—when emerging—opens new path understanding brainstem’s regulating synchronizing throughout brain.

Language: Английский

Sensory input, sex and function shape hypothalamic cell type development DOI Creative Commons
Harris S. Kaplan, Brandon L. Logeman, Kai Zhang

et al.

Nature, Journal Year: 2025, Volume and Issue: unknown

Published: March 5, 2025

Language: Английский

Citations

2
Sensory Input, Sex, and Function Shape Hypothalamic Cell Type Development DOI Creative Commons
Harris S. Kaplan, Brandon L. Logeman, Kai Zhang

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 23, 2024

Abstract Mammalian behavior and physiology undergo dramatic changes in early life. Young animals rely on conspecifics to meet their homeostatic needs, until weaning puberty initiate nutritional independence sex-specific social interactions, respectively. How neuronal populations regulating functions behaviors develop mature during these transitions remains unclear. We used paired transcriptomic chromatin accessibility profiling examine the developmental trajectories of hypothalamic preoptic region, where cell types with key roles physiological behavioral control have been identified 1–6 . These data reveal a remarkable diversity shaped by sex animal, location or function corresponding types. identify stages development, including perinatal emergence differences, postnatal maturation subsequent refinement signaling networks, nonlinear transcriptional accelerating at time puberty. assessed development various sensory mutants find major role for vomeronasal sensing timing type maturation. results provide novel insights into neurons controlling lay ground examining dynamics

Language: Английский

Citations

8
Conjoint specification of action by neocortex and striatum DOI Creative Commons
Junchol Park,

Peter Polidoro,

Cátia Fortunato

et al.

Neuron, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

1
Coincident development and synchronization of sleep-dependent delta in the cortex and medulla DOI
Midha Ahmad,

Jangjin Kim,

Brett Dwyer

et al.

Current Biology, Journal Year: 2024, Volume and Issue: 34(12), P. 2570 - 2579.e5

Published: May 20, 2024

Language: Английский

Citations

0
More Than a Small Brain: The Importance of Studying Neural Function during Development DOI
James C. Dooley, Meike E. van der Heijden

Journal of Neuroscience, Journal Year: 2024, Volume and Issue: 44(48), P. e1367242024 - e1367242024

Published: Nov. 27, 2024

The nervous system contains complex circuits comprising thousands of cell types and trillions connections. Here, we discuss how the field “developmental systems neuroscience” combines molecular genetic perspectives developmental neuroscience with (typically adult-focused) functional perspective neuroscience. This combination approaches is critical to understanding a handful cells eventually produce wide range behaviors necessary for survival. Functional circuit development typically lags behind neural connectivity, leading intermediate stages activity that are either not seen in adults or, if present, considered pathophysiological. Developmental examines these activity, mapping out phases inflection points function understand behavior emerge across development. Beyond typical development, this approach provides invaluable insight into pathophysiology neurodevelopmental disorders by identifying when diverges between health disease. We argue will identify important periods reveal novel therapeutic windows treatment, set stage answer fundamental questions about brain

Language: Английский

Citations

0
“Cortical Delta” in the Medulla of Sleeping Infant Rats DOI Creative Commons
Midha Ahmad,

Jangjin Kim,

Brett Dwyer

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 17, 2023

Summary In early development, active sleep is the predominant state before it supplanted by quiet sleep. rats, developmental increase in accompanied sudden emergence of cortical delta rhythm (0.5-4 Hz) around postnatal day 12 (P12). We sought to explain assessing changes activity parafacial zone (PZ), a medullary structure thought regulate adults. recorded from PZ P10 and P12 rats predicted an age-related neural during increasing periods delta-rich activity. Instead, we discovered sleep-dependent rhythmic spiking activity—with intervening total silence—phase-locked local rhythm. Moreover, were coherent at P12, but not P10. was also phase-locked respiration, suggesting modulation respiratory pacemakers ventral medulla. Disconnecting main olfactory bulbs cortex did diminish delta, indicating that influence respiration on this age mediated indirectly through nasal breathing. Finally, observed parvalbumin-expressing terminals across these ages, supporting role for GABAergic inhibition PZ’s rhythmicity. The discovery delta-rhythmic medulla—when emerging—opens new path understanding brainstem’s regulating synchronizing throughout brain.

Language: Английский

Citations

0