bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2022,
Номер
unknown
Опубликована: Май 15, 2022
Neuronal
population
activity
in
sensory
cortices
is
the
substrate
for
perceptual
decisions.
Yet,
we
still
do
not
understand
how
neuronal
information
content
relates
to
behavioral
reports.
To
reconcile
neurometric
and
psychometric
performance,
recorded
of
V1
neurons
mice
performing
a
Go/NoGo
orientation
discrimination
task.
We
found
that,
around
threshold,
does
represent
stimuli
as
canonically
expected.
Instead,
it
forms
categorical
representations
characterized
by
relocation
at
task-relevant
domains
representational
space.
The
relative
those
discrete
accurately
predicted
probabilities
animals’
Our
results
thus
suggest
that
integration
discretized
feature
from
explains
Cell Reports,
Год журнала:
2023,
Номер
42(9), С. 113133 - 113133
Опубликована: Сен. 1, 2023
Visual
stimuli
that
deviate
from
the
current
context
elicit
augmented
responses
in
primary
visual
cortex
(V1).
These
heightened
responses,
known
as
"deviance
detection,"
require
local
inhibition
V1
and
top-down
input
anterior
cingulate
area
(ACa).
Here,
we
investigated
mechanisms
by
which
ACa
interact
to
support
deviance
detection.
Local
field
potential
recordings
mice
during
an
oddball
paradigm
showed
ACa-V1
synchrony
peaks
theta/alpha
band
(≈10
Hz).
Two-photon
imaging
revealed
mainly
pyramidal
neurons
exhibited
detection,
while
contextually
redundant
increased
vasoactive
intestinal
peptide
(VIP)-positive
interneuron
(VIP)
activity
decreased
somatostatin-positive
(SST)
activity.
Optogenetic
drive
of
inputs
at
10
Hz
activated
V1-VIPs
but
inhibited
V1-SSTs,
mirroring
dynamics
present
paradigm.
Chemogenetic
disrupted
Aca-V1
detection
V1.
results
outline
temporal
interneuron-specific
modulation
processing.
iScience,
Год журнала:
2025,
Номер
28(2), С. 111728 - 111728
Опубликована: Янв. 2, 2025
The
visual
cortex
predicts
incoming
sensory
stimuli
through
internal
models
that
are
updated
following
unexpected
events.
Cortical
inhibitory
neurons,
particularly
vasoactive
intestinal
polypeptide
(VIP)
interneurons,
play
a
critical
role
in
representing
stimuli.
Notably,
this
response
is
stimulus
non-specific,
raising
the
question
of
what
information
it
conveys.
Given
their
unique
connectivity,
we
hypothesized
during
stimuli,
VIP
neurons
encode
broad
context
signals,
referred
to
here
as
task-independent
information.
To
test
hypothesis,
analyzed
Allen
Institute
Visual
Behavior
dataset,
which
mice
viewed
repeated
familiar
images
and
omissions
these
images,
while
two-photon
calcium
imaging
was
performed
from
distinct
cell
types
across
primary
higher-order
areas.
Using
dimensionality
reduction
methods,
found
that,
contrast
image
presentations,
trigger
signaling
excitatory
neurons.
This
may
facilitate
integration
contextual
information,
enabling
predictions.
Nature Communications,
Год журнала:
2025,
Номер
16(1)
Опубликована: Янв. 2, 2025
Neuronal
population
activity
in
sensory
cortices
is
the
substrate
for
perceptual
decisions.
Yet,
we
still
do
not
understand
how
neuronal
information
content
relates
to
behavioral
reports.
To
reconcile
neurometric
and
psychometric
performance,
recorded
of
V1
neurons
mice
performing
a
Go/NoGo
orientation
discrimination
task.
We
found
that,
around
threshold,
does
represent
stimuli
as
canonically
expected.
Instead,
it
forms
categorical
representations
characterized
by
relocation
at
task-relevant
domains
representational
space.
The
relative
those
discrete
accurately
predicted
probabilities
animals'
Our
results
thus
suggest
that
integration
discretized
feature
from
explains
How
animals
generate
decisions
remains
poorly
understood.
Here,
authors
show
during
task,
mouse
visual
cortex
encode
orientations
cues
but
probability
predicting
animal's
choice.
The Neuroscientist,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 8, 2025
Interneurons
(INs)
play
a
crucial
role
in
the
regulation
of
neural
activity
within
medial
prefrontal
cortex
(mPFC),
brain
region
critically
involved
executive
functions
and
behavioral
control.
In
recent
preclinical
studies,
dysregulation
INs
mPFC
has
been
implicated
pathophysiology
substance
use
disorder,
characterized
by
vulnerability
to
chronic
drug
use.
Here,
we
explore
diversity
their
connectivity
roles
addiction.
We
also
discuss
how
these
change
over
time
with
exposure.
Finally,
focus
on
noninvasive
stimulation
as
therapeutic
approach
for
targeting
highlighting
its
potential
restore
circuits.
Cell Reports,
Год журнала:
2025,
Номер
44(4), С. 115538 - 115538
Опубликована: Апрель 1, 2025
Under
the
predictive
coding
framework,
brain
generates
a
model
of
environment
based
on
previous
experiences.
Incoming
sensory
information
is
compared
to
this
model,
such
that
if
predictions
do
not
match
inputs,
prediction
error
generated.
Predictions
are
passed
top-down,
and
errors
emerge
when
bottom-up
does
predictions.
Prediction
occur
sequentially
in
primary
auditory
cortex
(A1)
then
medial
prefrontal
(mPFC).
Here,
we
test
hypothesis
mPFC
sends
contribute
generation
errors.
We
used
optogenetics
block
top-down
signals
from
while
recording
neuronal
A1
under
classical
"oddball"
paradigm.
Blocking
reduces
response
rare
sounds,
it
affect
responses
predictable
or
random
sounds.
Our
results
provide
empirical
evidence
for
enhance
unpredicted
stimuli.
