Genetically defined neuron types underlying visuomotor transformation in the superior colliculus
Nature reviews. Neuroscience,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 27, 2024
Язык: Английский
Gene-environmental regulation of the postnatal post-mitotic neuronal maturation
Gabrielle S. Prince,
Molly Reynolds,
Verdion Martina
и другие.
Trends in Genetics,
Год журнала:
2024,
Номер
40(6), С. 480 - 494
Опубликована: Апрель 23, 2024
Embryonic
neurodevelopment,
particularly
neural
progenitor
differentiation
into
post-mitotic
neurons,
has
been
extensively
studied.
While
the
number
and
composition
of
neurons
remain
relatively
constant
from
birth
to
adulthood,
brain
undergoes
significant
postnatal
maturation
marked
by
major
property
changes
frequently
disrupted
in
diseases.
This
review
first
summarizes
recent
characterizations
functional
molecular
nervous
system.
We
then
regulatory
mechanisms
controlling
precise
gene
expression
crucial
for
intricate
sequence
events,
highlighting
experience-dependent
versus
cell-intrinsic
genetic
timer
mechanisms.
Despite
advances
understanding
gene-environmental
regulation
neuronal
maturation,
many
aspects
unknown.
The
concludes
with
our
perspective
on
exciting
future
research
directions
next
decade.
Язык: Английский
Binocular processing facilitates escape behavior through multiple pathways to the superior colliculus
Current Biology,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 1, 2025
Язык: Английский
Evidence for a push-pull interaction between superior colliculi in monocular dynamic vision mode
Communications Biology,
Год журнала:
2025,
Номер
8(1)
Опубликована: Апрель 22, 2025
Visual
perception
can
operate
in
two
distinct
vision
modes-static
and
dynamic-that
have
been
associated
with
different
neural
activity
regimes
the
superior
colliculus
(SC).
However,
pathway-wide
mechanisms
remain
poorly
understood,
especially
terms
of
corticotectal
tectotectal
feedback
upon
encoding
continuity
illusion
during
dynamic
mode.
Here,
we
harness
functional
MRI
combined
rat
brain
lesions
to
investigate
whole-pathway
interactions
We
find
a
push-pull
mechanism
embodying
contralateral
suppression
SC
opposing
positive
ipsilateral
activation
monocular
visual
stimulation.
Cortical
amplification
is
confirmed
through
cortical
lesions,
while
further
lesioning
leads
boost
negative
signals,
suggesting
tectal
origin
for
interaction.
These
results
highlight
hitherto
unreported
frequency-dependent
modulations
pathway
challenge
notion
that
intertectal
connections
solely
serve
as
reciprocal
inhibitory
avoiding
blur
saccades.
Язык: Английский
Experience-dependent plasticity of multiple receptive field properties in lateral geniculate binocular neurons during the critical period
Frontiers in Cellular Neuroscience,
Год журнала:
2025,
Номер
19
Опубликована: Апрель 28, 2025
The
visual
thalamus
serves
as
a
critical
hub
for
feature
preprocessing
in
processing
pathways.
Emerging
evidence
demonstrates
that
experience-dependent
plasticity
can
be
revealed
by
monocular
deprivation
(MD)
the
dorsolateral
geniculate
nucleus
(dLGN)
of
thalamus.
However,
whether
and
how
this
thalamic
induces
changes
multiple
receptive
field
properties
potential
mechanisms
remain
unclear.
Using
vivo
electrophysiology,
here
we
show
binocular
neurons
dLGN
4-day
MD
mice
starting
at
P28
undergo
significant
ocular
dominance
(OD)
shift
during
period.
This
OD
could
attributed
to
potentiation
ipsilateral
eye
responses
but
not
depression
deprived
responses,
contrasting
with
conventional
observations
primary
cortex
(V1).
direction
orientation
selectivity
contralateral
these
neurons,
were
dramatically
reduced.
Developmental
analysis
pre-critical
period-associated
densities
both
GABA
positive
GABAA
receptor
α1
subunit
(GABRA1)
neurons.
early
compensatory
inhibition
from
V1
feedback
P18
maintained
network
stability
no
selectivity.
Mechanistically,
pharmacological
activation
receptors
rescued
MD-induced
shifts
impairments
period
mice,
operating
independently
feedback.
Furthermore,
under
different
contrast
levels
spatial
frequencies,
still
indicate
alterations
alone.
Together,
findings
provide
novel
insights
into
developmental
sensory
processing,
highlighting
an
active
participant
rather
than
merely
passive
relay
station.
identified
GABA-mediated
offer
therapeutic
targets
system
disorders.
Язык: Английский
Binocular processing facilitates escape behavior through multiple pathways to the superior colliculus
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 22, 2024
Summary
The
superior
colliculus
(SC)
is
the
main
brain
region
regulating
innate
defensive
behaviors
to
visual
threat.
Yet,
how
SC
integrates
binocular
information
and
what
extent
vision
drives
unknown.
Here,
we
show
that
facilitates
visually-evoked
escape
behavior.
Furthermore,
find
neurons
respond
input
with
diverse
synaptic
spiking
responses,
summate
inputs
largely
sublinearly.
Using
pathway-specific
optogenetic
silencing
contralateral
ipsilateral
carried
through
retinal,
interhemispheric
corticotectal
pathways.
These
pathways
carry
in
a
layer-specific
manner,
superficial
layers
receiving
retinal
input,
whereas
intermediate
deep
rely
on
Together,
our
data
shed
light
cellular
circuit
mechanisms
underlying
processing
its
role
Язык: Английский