Genetically defined neuron types underlying visuomotor transformation in the superior colliculus

Nature reviews. Neuroscience, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 27, 2024

Language: Английский

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Gene-environmental regulation of the postnatal post-mitotic neuronal maturation

Trends in Genetics, Journal Year: 2024, Volume and Issue: 40(6), P. 480 - 494

Published: April 23, 2024

Embryonic neurodevelopment, particularly neural progenitor differentiation into post-mitotic neurons, has been extensively studied. While the number and composition of neurons remain relatively constant from birth to adulthood, brain undergoes significant postnatal maturation marked by major property changes frequently disrupted in diseases. This review first summarizes recent characterizations functional molecular nervous system. We then regulatory mechanisms controlling precise gene expression crucial for intricate sequence events, highlighting experience-dependent versus cell-intrinsic genetic timer mechanisms. Despite advances understanding gene-environmental regulation neuronal maturation, many aspects unknown. The concludes with our perspective on exciting future research directions next decade.

Language: Английский

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Binocular processing facilitates escape behavior through multiple pathways to the superior colliculus

Current Biology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

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Evidence for a push-pull interaction between superior colliculi in monocular dynamic vision mode

Communications Biology, Journal Year: 2025, Volume and Issue: 8(1)

Published: April 22, 2025

Visual perception can operate in two distinct vision modes-static and dynamic-that have been associated with different neural activity regimes the superior colliculus (SC). However, pathway-wide mechanisms remain poorly understood, especially terms of corticotectal tectotectal feedback upon encoding continuity illusion during dynamic mode. Here, we harness functional MRI combined rat brain lesions to investigate whole-pathway interactions We find a push-pull mechanism embodying contralateral suppression SC opposing positive ipsilateral activation monocular visual stimulation. Cortical amplification is confirmed through cortical lesions, while further lesioning leads boost negative signals, suggesting tectal origin for interaction. These results highlight hitherto unreported frequency-dependent modulations pathway challenge notion that intertectal connections solely serve as reciprocal inhibitory avoiding blur saccades.

Language: Английский

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Experience-dependent plasticity of multiple receptive field properties in lateral geniculate binocular neurons during the critical period

Frontiers in Cellular Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: April 28, 2025

The visual thalamus serves as a critical hub for feature preprocessing in processing pathways. Emerging evidence demonstrates that experience-dependent plasticity can be revealed by monocular deprivation (MD) the dorsolateral geniculate nucleus (dLGN) of thalamus. However, whether and how this thalamic induces changes multiple receptive field properties potential mechanisms remain unclear. Using vivo electrophysiology, here we show binocular neurons dLGN 4-day MD mice starting at P28 undergo significant ocular dominance (OD) shift during period. This OD could attributed to potentiation ipsilateral eye responses but not depression deprived responses, contrasting with conventional observations primary cortex (V1). direction orientation selectivity contralateral these neurons, were dramatically reduced. Developmental analysis pre-critical period-associated densities both GABA positive A receptor α1 subunit (GABRA1) neurons. early compensatory inhibition from V1 feedback P18 maintained network stability no selectivity. Mechanistically, pharmacological activation receptors rescued MD-induced shifts impairments period mice, operating independently feedback. Furthermore, under different contrast levels spatial frequencies, still indicate alterations alone. Together, findings provide novel insights into developmental sensory processing, highlighting an active participant rather than merely passive relay station. identified GABA-mediated offer therapeutic targets system disorders.

Language: Английский

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Binocular processing facilitates escape behavior through multiple pathways to the superior colliculus

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 22, 2024

Summary The superior colliculus (SC) is the main brain region regulating innate defensive behaviors to visual threat. Yet, how SC integrates binocular information and what extent vision drives unknown. Here, we show that facilitates visually-evoked escape behavior. Furthermore, find neurons respond input with diverse synaptic spiking responses, summate inputs largely sublinearly. Using pathway-specific optogenetic silencing contralateral ipsilateral carried through retinal, interhemispheric corticotectal pathways. These pathways carry in a layer-specific manner, superficial layers receiving retinal input, whereas intermediate deep rely on Together, our data shed light cellular circuit mechanisms underlying processing its role

Language: Английский

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