Parallel mechanisms signal a hierarchy of sequence structure violations in the auditory cortex DOI Creative Commons
Sara Jamali, Sophie Bagur,

Enora Brémont

и другие.

eLife, Год журнала: 2024, Номер 13

Опубликована: Дек. 5, 2024

The brain predicts regularities in sensory inputs at multiple complexity levels, with neuronal mechanisms that remain elusive. Here, we monitored auditory cortex activity during the local-global paradigm, a protocol nesting different regularity levels sound sequences. We observed mice encode local predictions based on stimulus occurrence and transition probabilities, because responses are boosted upon prediction violation. This boosting was due to both short-term adaptation an adaptation-independent surprise mechanism resisting anesthesia. In parallel, only wakefulness, VIP interneurons responded omission of locally expected repeat sequence ending, thus providing chunking signal potentially useful for establishing global structure. When this structure violated, by either shortening or ending it but globally unexpected transition, slightly increased PV neurons, respectively. Hence, distinct cellular predict

Язык: Английский

Propofol-mediated loss of consciousness disrupts predictive routing and local field phase modulation of neural activity DOI Creative Commons
Yihan Xiong, Jacob Donoghue, Mikael Lundqvist

и другие.

Proceedings of the National Academy of Sciences, Год журнала: 2024, Номер 121(42)

Опубликована: Окт. 7, 2024

Predictive coding is a fundamental function of the cortex. The predictive routing model proposes neurophysiological implementation for coding. Predictions are fed back from deep-layer cortex via alpha/beta (8 to 30 Hz) oscillations. They inhibit gamma (40 100 and spiking that feed sensory inputs forward. Unpredicted arrive in circuits unprepared by alpha/beta, resulting enhanced spiking. To test its role consciousness, we collected data intracranial recordings macaque monkeys during passive presentation auditory oddballs before after propofol-mediated loss consciousness (LOC). In line with model, oscillations awake state served processing predictable stimuli. Propofol-mediated LOC eliminated modulation stimulus coherence between frontal areas. As result, oddball stimuli evoked power, late period (>200 ms onset) spiking, superficial layer sinks also resulted diminished decodability pattern-level prediction error signals higher-order Therefore, was disinhibited LOC. However, despite these feedforward responses cortex, there differential This may be consequence within-area interareal spike-field coupling frequency bands. These results provide strong constraints current theories consciousness.

Язык: Английский

Процитировано

8
An integrative view of the role of prefrontal cortex in consciousness DOI
Theofanis I. Panagiotaropoulos

Neuron, Год журнала: 2024, Номер 112(10), С. 1626 - 1641

Опубликована: Май 1, 2024

Язык: Английский

Процитировано

6
Predictive acoustical processing in human cortical layers DOI Creative Commons
Lonike K. Faes, Isma Zulfiqar, Luca Vizioli

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Янв. 10, 2025

Abstract In our dynamic environments, predictive processing is vital for auditory perception and its associated behaviors. Predictive coding formalizes inferential processes by implementing them as information exchange across cortical layers areas. With laminar-specific blood oxygenation level dependent we measured responses to a cascading oddball paradigm, ground on the mesoscopic human architecture. We show that violation of predictions are potentially hierarchically organized with in superficial planum polare middle lateral temporal cortex. Moreover, relate updating brain’s internal model changes deep layers. Using modeling approach, derive putative neural dynamics while accounting draining effects. Our results support role architecture implementation highlight ability laminar fMRI investigate large extent

Язык: Английский

Процитировано

0
Unpacking the Complexities of Consciousness: Theories and Reflections DOI Creative Commons
Liad Mudrik, Mélanie Boly,

Stanislas Dehaene

и другие.

Neuroscience & Biobehavioral Reviews, Год журнала: 2025, Номер unknown, С. 106053 - 106053

Опубликована: Фев. 1, 2025

As the field of consciousness science matures, research agenda has expanded from an initial focus on neural correlates consciousness, to developing and testing theories consciousness. Several have been put forward, each aiming elucidate relationship between brain function. However, there is ongoing, intense debate regarding whether these examine same phenomenon. And, despite ongoing efforts, it seems like so far failed converge around any single theory, instead exhibits significant polarization. To advance this discussion, proponents five prominent consciousness-Global Neuronal Workspace Theory (GNWT), Higher-Order Theories (HOT), Integrated Information (IIT), Recurrent Processing (RPT), Predictive (PP)-engaged in a public 2022, as part annual meeting Association for Scientific Study Consciousness (ASSC). They were invited clarify explananda their theories, articulate core mechanisms underpinning corresponding explanations, outline foundational premises. This was followed by open discussion that delved into testability potential evidence could refute them, areas consensus disagreement. Most importantly, demonstrated at stage, more controversy than agreement pertaining most basic questions what is, how identify conscious states, required theory Addressing crucial advancing towards deeper understanding comparison competing theories.

Язык: Английский

Процитировано

0
Predictive coding: a more cognitive process than we thought? DOI

Kaitlyn M Gabhart,

Y. Xiong, André M. Bastos

и другие.

Trends in Cognitive Sciences, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
Parallel mechanisms signal a hierarchy of sequence structure violations in the auditory cortex DOI Creative Commons
Sara Jamali, Sophie Bagur,

Enora Brémont

и другие.

eLife, Год журнала: 2024, Номер 13

Опубликована: Ноя. 7, 2024

The brain predicts regularities in sensory inputs at multiple complexity levels, with neuronal mechanisms that remain elusive. Here, we monitored auditory cortex activity during the local-global paradigm, a protocol nesting different regularity levels sound sequences. We observed mice encode local predictions based on stimulus occurrence and transition probabilities, because responses are boosted upon prediction violation. This boosting was due to both short-term adaptation an adaptation-independent surprise mechanism resisting anesthesia. In parallel, only wakefulness, VIP interneurons responded omission of locally expected repeat sequence ending, thus providing chunking signal potentially useful for establishing global structure. When this structure violated, by either shortening or ending it but globally unexpected transition, slightly increased PV neurons, respectively. Hence, distinct cellular predict

Язык: Английский

Процитировано

3
Stimulus history, not expectation, drives sensory prediction errors in mammalian cortex DOI Creative Commons
Jacob A. Westerberg, Yihan Xiong,

Hamed Nejat

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Окт. 3, 2024

Predictive coding (PC) hypothesizes that the brain computes internal models of predicted events and unpredicted stimuli are signaled with prediction errors feed forward. We tested this hypothesis using a visual oddball task. A repetitive sequence interrupted by novel stimulus is "local" oddball. "Global" oddballs defy predictions while repeating local context, thereby dissociating genuine from adaptation-related responses. recorded neuronal spiking activity across hierarchy in mice monkeys viewing these oddballs. Local responses largely followed PC: they were robust, emerged early layers 2/3, fed Global challenged weak, absent most areas, more robust prefrontal cortex, non-granular layers, did not involve inhibitory interneurons relaying predictive suppression. Contrary to PC, does emerge sensory processing, instead exclusive cognitive, higher-order areas. Core principles Coding explain local, but global responsesGlobal sparsely encoded cortex do engage feedforward mechanismsParvalbumin somatostatin support detectionGlobal earliest, robustly encoded, our expectations without standing out their context. Whether areas was uncertain. Through multiarea neurophysiological recordings monkeys, Westerberg et al. show contradicts hypotheses higher order

Язык: Английский

Процитировано

2
Different subregions of monkey lateral prefrontal cortex respond to abstract sequences and their components DOI Creative Commons
Nadira Yusif Rodriguez, Aarit Ahuja, Debaleena Basu

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Фев. 14, 2024

Abstract Sequential information permeates daily activities, such as when watching for the correct series of buildings to determine get off bus or train. These sequences include periodicity (the spacing buildings), identity stimuli kind house), and higher-order more abstract rules that may not depend on exact stimulus (e.g. house, business). Previously, we found posterior fundus area 46 in monkey lateral prefrontal cortex (LPFC) responds rule changes visual sequences. However, it is unknown if this region other components sequence, i.e., image identity, isolation. Further, dissociates from other, ventral LPFC subregions have been associated with their components. To address these questions, used awake functional magnetic resonance imaging three male macaque monkeys during two no-report tasks. One task contained sequences, no but maintained same identities. We responded only sequence violations. In contrast, bank sequence. results suggest a specialization within anatomical substructures signal different kinds regularities. This provide key scaffolding identify patterns construct complex models world living. Significance Statement Daily tasks, commute, require tracking monitoring your place (same, same, building) until stop. Sequence rule, (timing), item are involved process. While prior work located responses using fMRI, less was known about differentiated between Area changes, identity. The converse true ventral, adjacent shoulder region. interactions behaviors.

Язык: Английский

Процитировано

1
Parallel mechanisms signal a hierarchy of sequence structure violations in the auditory cortex DOI Creative Commons
Sara Jamali, Sophie Bagur,

Enora Brémont

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Авг. 22, 2024

Abstract The brain predicts regularities in sensory inputs at multiple complexity levels, with neuronal mechanisms that remain elusive. Here, we monitored auditory cortex activity during the local-global paradigm, a protocol nesting different regularity levels sound sequences. We observed mice encode local predictions based on stimulus occurrence and transition probabilities, because responses are boosted upon prediction violation. This boosting was due to both short-term adaptation an adaptation-independent surprise mechanism resisting anesthesia. In parallel, only wakefulness, VIP interneurons responded omission of locally expected repeat sequence ending, thus providing chunking signal potentially useful for establishing global structure. When this structure violated, by either shortening or ending it but globally unexpected transition, slightly increased PV neurons respectively. Hence, distinct cellular predict

Язык: Английский

Процитировано

1
Different subregions of monkey lateral prefrontal cortex respond to abstract sequences and their components DOI
Nadira Yusif Rodriguez, Aarit Ahuja, Debaleena Basu

и другие.

Journal of Neuroscience, Год журнала: 2024, Номер 44(47), С. e1353242024 - e1353242024

Опубликована: Окт. 8, 2024

Sequential information permeates daily activities, such as when watching for the correct series of buildings to determine get off bus or train. These sequences include periodicity (the spacing buildings), identity stimuli kind house), and higher-order more abstract rules that may not depend on exact stimulus (e.g., house, business). Previously, we found posterior fundus area 46 in monkey lateral prefrontal cortex (LPFC) responds rule changes visual sequences. However, it is unknown if this region other components sequence, i.e., image identity, isolation. Further, dissociates from other, ventral LPFC subregions have been associated with their components. To address these questions, used awake functional magnetic resonance imaging three male macaque monkeys during two no-report tasks. One task contained sequences, no but maintained same identities. We responded only sequence violations. In contrast, bank sequence. results suggest a specialization within anatomical substructures signal different kinds regularities. This provide key scaffolding identify patterns construct complex models world living.

Язык: Английский

Процитировано

1