International Journal of Environmental Research and Public Health,
Год журнала:
2025,
Номер
22(4), С. 521 - 521
Опубликована: Март 28, 2025
COVID-19
survivors
often
experience
late
symptoms,
possibly
secondary
to
an
exacerbated
inflammatory
response.
This
study
aimed
investigate
whether
levels,
assessed
by
the
neutrophil-to-lymphocyte
ratio
(NLR)
during
hospitalization
in
acute
phase
of
SARS-CoV-2
infection,
affect
skeletal
muscle
phenotype
and
adipose
tissue
outpatient
follow-up
after
discharge.
retrospective,
single-center
included
hospitalized
from
March
2020
April
2021,
who
attended
follow-ups
3
9
months
Patients
were
divided
into
two
groups
based
on
levels
hospitalization:
(1)
low
NLR
(≤4.2)
(2)
high
(>4.2).
The
using
computed
tomography.
60
patients:
20
40
NLR.
group
was
unexpectedly
younger,
but
had
longer
hospital
stays
required
more
intensive
care.
We
observed
a
reduction
radiodensity
increase
fat
both
groups.
However,
we
no
differences
subcutaneous
visceral
between
follow-up.
conclude
that
show
reduced
increased
infiltration
post-hospitalization,
regardless
infection.
In
addition,
age
intramuscular
are
associated
with
reducing
radiodensity.
highlights
need
for
targeted
rehabilitation
address
long-term
effects
recovery.
Clinical Nutrition,
Год журнала:
2022,
Номер
41(10), С. 2244 - 2263
Опубликована: Авг. 7, 2022
Low
muscle
mass
and
malnutrition
are
prevalent
conditions
among
adults
of
all
ages,
with
any
body
weight
or
index,
acute
chronic
conditions,
including
COVID-19.
This
article
synthesizes
the
latest
research
advancements
in
health
malnutrition,
their
impact
on
immune
function,
clinical
outcomes.
We
provide
a
toolkit
illustrations
scientific
information
that
healthcare
professionals
can
use
for
knowledge
translation,
educating
patients
about
importance
identifying
treating
low
malnutrition.
focus
emerging
evidence
mitochondrial
dysfunction
context
aging
disease,
as
well
cross-talk
between
skeletal
system.
address
myosteatosis
component
composition,
discuss
direct,
indirect
surrogate
assessments
ultrasound,
computerized
tomography,
deuterated
creatine
dilution,
calf
circumference.
Assessments
function
also
included
(handgrip
strength,
physical
performance
tests).
Finally,
we
nutrition
interventions
to
support
anabolism,
reduce
catabolism,
improve
patient
These
include
protein
amino
acids,
branched-chain
leucine;
β-hydroxy-β-methylbutyrate
(HMB),
vitamin
D;
n-3
polyunsaturated
fatty
acids
(n-3
PUFA),
polyphenols,
oral
nutritional
supplements.
concluded
recommendations
practice
call
action
focusing
evaluating
composition
targeted
interventions,
consequently
ability
JAMA Internal Medicine,
Год журнала:
2024,
Номер
184(4), С. 414 - 414
Опубликована: Фев. 26, 2024
Importance
COVID-19
infection
is
associated
with
a
high
incidence
of
acute
kidney
injury
(AKI).
Although
rapid
function
decline
has
been
reported
in
the
first
few
months
after
COVID-19−associated
AKI
(COVID-AKI),
longer-term
association
COVID-AKI
remains
unknown.
Objective
To
assess
long-term
outcomes
patients
who
had
AKI.
Design,
Setting,
and
Participants
This
was
retrospective
longitudinal
multicenter
cohort
study
conducted
large
hospital
system
using
electronic
health
records
data
on
adult
hospitalized
or
other
illnesses.
Included
were
during
pandemic
(March
2020-June
2022),
screened
for
SARS-CoV-2,
AKI,
survived
to
discharge,
5
years
before
(October
2016-January
2020),
positive
influenza
A
B
test
result,
discharge.
Patients
followed
up
maximum
2
Data
analyses
performed
from
December
2022
November
2023.
Exposure
influenza.
Main
Outcomes
Measures
The
primary
outcome
major
adverse
events
(MAKE),
defined
as
composite
mortality
worsened
(estimated
glomerular
filtration
rate
[eGFR]
by
≥25%
discharge
eGFR
failure
requiring
dialysis).
Multivariable
time-to-event
compare
MAKE
between
individuals
those
illnesses
same
period.
For
further
comparison,
this
assessed
historic
influenza-associated
Results
included
9624
(mean
[SD]
age,
69.0
[15.7]
years;
4955
[51.5%]
females)
including
987
COVID-AKI,
276
8361
(other-AKI).
Compared
groups,
slightly
younger
higher
baseline
eGFR,
worse
comorbidity
scores,
markers
illness
severity,
longer
stay.
other-AKI
group,
group
lower
(adjusted
hazard
ratio
[aHR],
0.67;
95%
CI,
0.59-0.75)
due
all-cause
(aHR,
0.31;
0.24-0.39)
rates
0.78;
0.69-0.88).
Conclusions
Relevance
findings
indicate
that
survivors
hospitalization
experience
MAKE,
decline,
compared
Journal of Investigative Medicine,
Год журнала:
2023,
Номер
71(5), С. 545 - 562
Опубликована: Март 6, 2023
In
late
2019,
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
triggered
the
global
disease
2019
(COVID-19)
pandemic.
Although
most
infections
cause
a
self-limited
comparable
to
other
upper
viral
pathogens,
portion
of
individuals
develop
illness
leading
substantial
morbidity
and
mortality.
Furthermore,
an
estimated
10%–20%
SARS-CoV-2
are
followed
by
post-acute
sequelae
COVID-19
(PASC),
or
long
COVID.
Long
COVID
is
associated
with
wide
variety
clinical
manifestations
including
cardiopulmonary
complications,
persistent
fatigue,
neurocognitive
dysfunction.
Severe
hyperactivation
increased
inflammation,
which
may
be
underlying
in
subset
individuals.
However,
immunologic
mechanisms
driving
development
still
under
investigation.
Early
pandemic,
our
group
others
observed
immune
dysregulation
persisted
into
convalescence
after
COVID-19.
We
subsequently
cohort
experiencing
demonstrated
SARS-CoV-2-specific
CD4
+
CD8
T-cell
responses
antibody
affinity
patients
symptoms.
These
data
suggest
symptoms
due
chronic
activation
presence
antigen.
This
review
summarizes
literature
date
detailing
how
these
observations
relate
addition,
we
discuss
recent
findings
support
antigen
evidence
that
this
phenomenon
contributes
local
systemic
inflammation
heterogeneous
nature
seen
Turkish Journal of Physical Medicine and Rehabilitation,
Год журнала:
2023,
Номер
1(1), С. 1 - 7
Опубликована: Фев. 28, 2023
The
worldwide
pandemic
of
coronavirus
disease
2019
(COVID-19)
was
known
to
predominantly
affect
the
lungs,
but
it
realized
that
COVID-19
had
a
large
variety
clinical
involvement.
Cardiovascular,
gastrointestinal,
neurological,
and
musculoskeletal
systems
are
involved
by
direct
or
indirect
mechanisms
with
various
manifestations.
involvement
can
manifest
during
infection,
due
medications
used
for
treatment
COVID-19,
in
post/long
syndrome.
major
symptoms
fatigue,
myalgia/arthralgia,
back
pain,
low
chest
pain.
During
last
two
years,
increased,
no
clear
consensus
obtained
about
pathogenesis.
However,
there
is
valuable
data
supports
hypothesis
angiotensinconverting
enzyme
2,
inflammation,
hypoxia,
muscle
catabolism.
Additionally,
were
also
have
adverse
effects,
such
as
corticosteroid-induced
myopathy
osteoporosis.
Therefore,
while
deciding
drugs,
priorities
benefits
should
be
taken
into
consideration.
Symptoms
begin
three
months
from
onset
continue
at
least
months,
cannot
explained
another
diagnosis
accepted
Prior
may
persist
fluctuate,
new
manifest.
In
addition,
must
one
symptom
infection.
Most
common
myalgia,
arthralgia,
weakness,
sarcopenia,
impaired
exercise
capacity,
physical
performance.
female
sex,
obesity,
elderly
patients,
hospitalization,
prolonged
immobility,
having
mechanical
ventilation,
not
vaccination,
comorbid
disorders
predictors
Musculoskeletal
pain
problem
tends
chronic
form.
There
on
mechanism,
inflammation
angiotensin-converting
2
seem
play
an
important
role.
Localized
generalized
occur
after
general
localized
An
accurate
allows
physicians
initiate
management
proper
rehabilitation
programs.
