A bibliometric analysis of emerging contaminants (ECs) (2001−2021): Evolution of hotspots and research trends

The Science of The Total Environment, Год журнала: 2023, Номер 907, С. 168116 - 168116

Опубликована: Окт. 24, 2023

Язык: Английский

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Occurrence, toxicity, impact and removal of selected non-steroidal anti-inflammatory drugs (NSAIDs): A review

The Science of The Total Environment, Год журнала: 2023, Номер 898, С. 165317 - 165317

Опубликована: Июль 6, 2023

Язык: Английский

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Environmental Metabolomics Promises and Achievements in the Field of Aquatic Ecotoxicology: Viewed through the Pharmaceutical Lens

Metabolites, Год журнала: 2022, Номер 12(2), С. 186 - 186

Опубликована: Фев. 17, 2022

Scientists often set ambitious targets using environmental metabolomics to address challenging ecotoxicological issues. This promising approach has a high potential elucidate the mechanisms of action (MeOAs) contaminants (in hazard assessments) and develop biomarkers biomonitoring). However, fingerprints involve complex mixture molecular effects that are hard link specific MeOA (if detected in analytical conditions used). Given these promises limitations, here we propose an updated review on achievements this approach. Metabolomics-based studies conducted pharmaceutical active compounds aquatic organisms provide relevant means approach, as prior knowledge about molecules could help overcome some shortcomings. highlighted current advances have enabled more accurate assessment, especially when combined with other omics approaches. The combination measured biological endpoints also turned out be efficient way (sub)-individual adverse outcomes, thereby paving construction outcome pathways (AOPs). Here, discuss importance determining key strategy identification MeOA-specific for biomonitoring. We put forward recommendations take full advantage thus fulfil promises.

Язык: Английский

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On Multi‐Model Assessment of Complex Degradation Paths: The Fate of Diclofenac and Its Transformation Products

Water Resources Research, Год журнала: 2023, Номер 59(1)

Опубликована: Янв. 1, 2023

Abstract We present a methodology to quantify the impact of model structure and parametric uncertainty on formulations targeting biotransformation processes Emerging Contaminants in subsurface water resources. The study is motivated by recognizing that modeling bio‐mediated reactions recalcitrant compounds soil aquifers plagued uncertainty. At same time, process‐based models often require parameterization complex physico‐chemical processes, situation which exacerbated paucity direct observations. Thus, assessment formulation tools capable balance complexity reliability key challenge. strategy proposed here aims at pairing applying suite quantitative starting from prior diagnosis multiple sources leading parameter estimation selection presence limited number illustrated through application multi‐step, reactive scenario involving pharmaceutical diclofenac (DCF) groundwater. Our framework includes four plausible models. These are obtained successive simplifications recently developed highly model. Such accomplished consistent with results comprehensive Multi‐Model Global Sensitivity Analysis. latter allows ranking levels influence system outputs incorporating effects uncertainties. kinetic loop‐initiating process (DCF nitrosation, linked temporal evolution N‐cycle components) documented as dominating explaining variability environmental interest. Model discrimination criteria suggest simplified counterpart reference favored interpret available data. approach can assist interpretation prototyping wide range contaminant objective also for purpose developing credible (environmental) risk designing experimental sampling campaigns.

Язык: Английский

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Impact of fluoxetine exposure on Lymnaea stagnalis and its developing eggs: integrating untargeted lipidomics, targeted metabolomics, and classical risk assessment

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Фев. 4, 2025

Pharmaceuticals such as selective serotonin reuptake inhibitors (SSRIs), are increasingly detected in aquatic environments, posing potential risks to non-target organisms, because many of those substances widely shared neuromodulator. In this study, we investigated the effects SSRI antidepressant, namely, fluoxetine, exposure on freshwater snail L. stagnalis , focusing egg development, neurochemical pathways, and lipid metabolism. Snails were exposed a range 51–434 µg fluoxetine L⁻ 1 for 7 days, followed by analysis survival, feeding behaviour, reproduction, metabolomic changes central nervous system (CNS), albumen gland, eggs. Although no significant observed survival or fecundity, significantly impaired development dose-dependent manner, reducing hatching rates with an EC50 126 . Removal eggs from contaminated environment partially reversed these developmental effects, suggesting recovery if levels decrease. Molecular revealed several lipidomic alterations. CNS, elevated catecholamines, phosphatidylcholines (PC), ceramides linked disruptions neurotransmission, membrane integrity, embryo development. decrease key classes, including sphingomyelins fatty acids, which can be quality. Additionally, histamine both gland suggested further disruption potentially affecting metamorphosis success. Moreover, increase choline, along PC oxidized PC, indicated oxidative stress peroxidation CNS Lymnaea Our findings highlight benefits combining behavioral assessments profiling better understand mechanistic pathways underlying fluoxetine’s adverse effects.

Язык: Английский

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Unveiling combined ecotoxicity: Interactions and impacts of engineered nanoparticles and PPCPs

The Science of The Total Environment, Год журнала: 2024, Номер 921, С. 170746 - 170746

Опубликована: Фев. 9, 2024

Язык: Английский

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Metabolomic‐Based Comparison of Daphnia magna and Japanese Medaka Responses After Exposure to Acetaminophen, Diclofenac, and Ibuprofen

Environmental Toxicology and Chemistry, Год журнала: 2024, Номер 43(6), С. 1339 - 1351

Опубликована: Апрель 25, 2024

Abstract Pharmaceuticals are found in aquatic environments due to their widespread use and environmental persistence. To date, a range of impairments organisms has been reported with exposure pharmaceuticals; however, further comparisons impacts across different species on the molecular level needed. In present study, crustacean Daphnia magna freshwater fish Japanese medaka, common model toxicity, were exposed for 48 h analgesics acetaminophen (ACT), diclofenac (DCF), ibuprofen (IBU) at sublethal concentrations. A targeted metabolomic-based approach, using liquid chromatography–tandem mass spectrometry quantify polar metabolites from individual daphnids was used. Multivariate analyses metabolite changes identified differences profile D. more metabolic perturbations magna. Pathway uncovered disruptions pathways associated protein synthesis amino acid metabolism all three analgesics. contrast, medaka resulted disrupted DCF only not ACT IBU. Overall, observed biochemistry both consistent assessments other endpoints reporting that is sensitive pollutants than short-term studies. Our findings demonstrate molecular-level responses analgesic can reflect observations endpoints, such as immobilization mortality. Thus, metabolomics be valuable tool selecting sentinel biomonitoring ecosystems while also uncovering mechanistic information. Environ Toxicol Chem 2024;43:1339–1351. © 2024 The Authors. Environmental Toxicology Chemistry published by Wiley Periodicals LLC behalf SETAC.

Язык: Английский

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Organo magadiites for diclofenac adsorption: influence of the surfactant chain

Environmental Science and Pollution Research, Год журнала: 2024, Номер 31(42), С. 54695 - 54712

Опубликована: Авг. 30, 2024

Язык: Английский

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Mixture effects of pharmaceuticals carbamazepine, diclofenac and venlafaxine on Mytilus galloprovincialis mussel probed by metabolomics and proteogenomics combined approach

The Science of The Total Environment, Год журнала: 2023, Номер 907, С. 168015 - 168015

Опубликована: Окт. 23, 2023

Язык: Английский

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Diclofenac Degradation by Immobilized Chlamydomonas reinhardtii and Scenedesmus obliquus

MicrobiologyOpen, Год журнала: 2024, Номер 13(6)

Опубликована: Дек. 1, 2024

ABSTRACT Diclofenac (DCF), a commonly used anti‐inflammatory medication, presents environmental concerns due to its presence in water bodies, resistance conventional wastewater treatment methods, and detection at increasing concentrations (ng/L µg/L) that highlight DCF as global emerging pollutant. While microalgae have been effective degrading wastewater, immobilization into matrix offers promising approach enhance retention efficiency. This study aimed evaluate the efficacy of removal using immobilized freshwater microalgae. Two algal species, Chlamydomonas reinhardtii ( ) Scenedesmus obliquus ), were tested for 6 days both free forms determine if algae could degrade comparably cells. The findings indicate by Day 3, removed 78.0% 80.1% DCF, outperforming free‐cell cultures. Mixed cultures demonstrated synergistic effects, with amounts 91.4% 92.3% systems. By 6, all conditions achieved complete (100%). Mechanistic analysis showed 80.0% biodegradation 20.0% bioaccumulation 56.8% 43.2% . Immobilization shifted pathways slightly: , 61.6% occurred via biodegradation, 18.3% bioaccumulation, 20.1% abiotic degradation. For 45.6% 36.6% 17.8% degradation, enhancing degradation while maintaining research serves proof concept utilizing suggests an avenue improved contaminants.

Язык: Английский

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