Background:
Toxic
heavy
metal
exposure
and
insufficiency
or
excess
of
essential
metals
may
have
negative
effects
on
pregnant
women’s
health
fetal
growth.
To
date,
the
predictors
levels
remain
unclear
vary
with
different
regions.
The
study
intended
to
explore
potential
individually
high
co-exposure
mixtures.Methods:
We
recruited
298
women
in
first
trimester
from
prenatal
clinics
Jinan,
Shandong
Province,
China,
collected
spot
urine
samples
questionnaire
data
their
demographic
characteristics,
lifestyle
habits,
consumption
food
dietary
supplement,
residential
environment.
All
were
analyzed
for
seven
metals:
cobalt
(Co),
molybdenum
(Mo),
strontium
(Sr),
arsenic
(As),
cadmium
(Cd),
lead
(Pb)
mercury
(Hg).Results:
Factors
associated
single
concentration
as
follows:
a)
urinary
As,
Sr
Cd
increased
age
respectively;
b)
higher
monthly
household
income
per
capita
had
lower
Mo
levels;
c)
intermittent
folic
acid
supplementation
those
not
taking
tap
water
domestic
drinking
concentrations;
d)
was
positively
linked
frequency
rice;
e)
Hg
adversely
related
egg
who
took
purified
exposure.
In
addition,
odds
Co,
Sr,
Mo,
Pb;
while
an
educational
level
college
such
a
mixture.Conclusion:
Our
quantified
metals,
namely
Cd,
Pb
during
China.
our
knowledge,
this
is
these
mixtures,
broad
pool
variables.
This
work
contributes
better
understanding
factors
sources
provides
valuable
evidence
possible
strategies
future
studies
reduce
among
women.
Nature Communications,
Год журнала:
2025,
Номер
16(1)
Опубликована: Март 1, 2025
Prenatal
exposure
to
metals
has
been
associated
with
impaired
neurodevelopment
in
children,
but
the
detailed
molecular
mechanisms
remain
largely
unknown.
Based
on
Wuhan
Healthy
Baby
Cohort,
China
(N
=
1088),
eleven
were
measured
maternal
urine
during
early
pregnancy
(13.1
±
1.1
weeks)
and
metabolomics
profiling
was
conducted
cord
blood.
Neurodevelopment
evaluated
using
Bayley
Scales
of
Infant
Development
2-year-old
children
obtain
mental
development
index
(MDI)
psychomotor
(PDI).
After
false
discovery
rate
correction,
higher
urinary
levels
manganese,
nickel,
aluminum,
rubidium,
gallium,
summary
score
only
significantly
lower
MDI
scores.
The
weighted
quantile
sum
metal
mixture
showed
a
significant
inverse
association
PDI
scores,
aluminum
contributing
most
associations.
Histidine,
beta-alanine,
purine,
pyrimidine
metabolism
mediated
above
associations,
suggesting
that
disturbances
amino
acids,
neurotransmitter
neuroendocrine
may
be
important
mediators
children.
linked
underlying
are
unclear.
Here,
authors
show
neurotransmitters,
mediate
association.
Cells,
Год журнала:
2024,
Номер
13(21), С. 1775 - 1775
Опубликована: Окт. 26, 2024
Heavy
metals
like
arsenic,
mercury,
cadmium,
and
lead
are
harmful
pollutants
that
can
change
how
our
genes
regulated
without
altering
the
DNA
sequence,
specifically
through
a
process
called
methylation
(DNAm)
at
5-methylcytosine,
an
epigenetic
mark
we
will
focus
on
in
this
review.
These
changes
DNAm
most
sensitive
during
pregnancy,
critical
time
for
development
when
these
modifications
affect
traits
expressed.
Historically,
research
environmental
effects
has
focused
adults,
but
now
there
is
more
emphasis
studying
impacts
early
childhood.
The
placenta
acts
as
protective
barrier
between
mother
baby,
by
examining
it,
scientists
identify
key
might
long-term
health.
This
review
looks
exposure
to
heavy
pregnancy
cause
gene
regulation
newborns,
seen
their
umbilical
cord
blood.
reflect
baby’s
genetic
state
be
influenced
mother’s
environment
genetics,
well
own
genetics.
Nutrients,
Год журнала:
2023,
Номер
15(15), С. 3348 - 3348
Опубликована: Июль 27, 2023
Molybdenum
is
an
essential
trace
element
for
human
health
and
survival,
with
molybdenum-containing
enzymes
catalysing
multiple
reactions
in
the
metabolism
of
purines,
aldehydes,
sulfur-containing
amino
acids.
Recommended
daily
intakes
vary
globally,
molybdenum
primarily
sourced
through
diet,
supplementation
not
common.
Although
benefits
as
anti-diabetic
antioxidant
inducer
have
been
reported
literature,
there
are
conflicting
data
on
chronic
diseases.
Overexposure
deficiency
can
result
adverse
outcomes
mortality,
although
physiological
doses
remain
largely
unexplored
relation
to
health.
The
lack
knowledge
surrounding
intake
role
it
plays
physiology
compounded
during
pregnancy.
As
pregnancy
progresses,
micronutrient
demand
increases,
diet
established
factor
programming
gestational
maternal
This
review
summarises
current
literature
concerning
varied
recommendations
intake,
molybdoenzymes
physiology,
contribution
these
play
outcomes.
Frontiers in Public Health,
Год журнала:
2025,
Номер
13
Опубликована: Май 1, 2025
Previous
studies
have
identified
that
exposure
to
heavy
metals
increases
the
prevalence
of
congenital
heart
defects
(CHDs);
however,
limited
information
exists
regarding
association
between
combined
barium
(Ba)
and
arsenic
(As),
CHDs.
This
study
aims
investigate
prenatal
Ba
As
(both
independently
in
combination)
risk
CHDs
offspring.
In
a
birth
cohort
conducted
Lanzhou,
China,
total
97
mother-newborn
pairs
were
designated
as
case
group,
with
an
additional
194
constituting
control
group.
The
concentrations
maternal
blood
quantified
utilizing
inductively
coupled
plasma
mass
spectrometer.
A
multivariate
logistic
regression
model
was
employed
examine
levels
neonatal
their
subtypes.
Interaction
effects
further
evaluated
through
application
both
additive
multiplicative
models.
concentration
pregnant
women
is
positively
correlated
levels.
Higher
level
associated
greater
odds
(p
=
0.008),
including
isolated
0.013),
multiple
0.032),
PDA
0.014),
ASDs
0.031);
Similarly,
higher
0.016),
0.003),
0.005),
0.017),
AVSDs
0.034).
Elevated
significantly
increased
subtypes
offspring
(All
p
<
0.05).
Furthermore,
significant
interaction
relation
0.04).
Exposure
or
individually,
well
both,
