Predictors of Urinary Heavy Metal Concentrations Among Pregnant Women in Jinan, China DOI

Jiayi Song,

Xiang Wang,

Qichen Huang

et al.

Published: Jan. 1, 2023

Background: Toxic heavy metal exposure and insufficiency or excess of essential metals may have negative effects on pregnant women’s health fetal growth. To date, the predictors levels remain unclear vary with different regions. The study intended to explore potential individually high co-exposure mixtures.Methods: We recruited 298 women in first trimester from prenatal clinics Jinan, Shandong Province, China, collected spot urine samples questionnaire data their demographic characteristics, lifestyle habits, consumption food dietary supplement, residential environment. All were analyzed for seven metals: cobalt (Co), molybdenum (Mo), strontium (Sr), arsenic (As), cadmium (Cd), lead (Pb) mercury (Hg).Results: Factors associated single concentration as follows: a) urinary As, Sr Cd increased age respectively; b) higher monthly household income per capita had lower Mo levels; c) intermittent folic acid supplementation those not taking tap water domestic drinking concentrations; d) was positively linked frequency rice; e) Hg adversely related egg who took purified exposure. In addition, odds Co, Sr, Mo, Pb; while an educational level college such a mixture.Conclusion: Our quantified metals, namely Cd, Pb during China. our knowledge, this is these mixtures, broad pool variables. This work contributes better understanding factors sources provides valuable evidence possible strategies future studies reduce among women.

Language: Английский

Independent and combined associations of urinary metals exposure with markers of liver injury: Results from the NHANES 2013–2016 DOI
Peng Tang, Qian Liao, Yan Tang

et al.

Chemosphere, Journal Year: 2023, Volume and Issue: 338, P. 139455 - 139455

Published: July 8, 2023

Language: Английский

Citations

25
Associations of prenatal metal exposure with child neurodevelopment and mediation by perturbation of metabolic pathways DOI Creative Commons

Ya Jie Xie,

Han Xiao, Dan Zheng

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 1, 2025

Prenatal exposure to metals has been associated with impaired neurodevelopment in children, but the detailed molecular mechanisms remain largely unknown. Based on Wuhan Healthy Baby Cohort, China (N = 1088), eleven were measured maternal urine during early pregnancy (13.1 ± 1.1 weeks) and metabolomics profiling was conducted cord blood. Neurodevelopment evaluated using Bayley Scales of Infant Development 2-year-old children obtain mental development index (MDI) psychomotor (PDI). After false discovery rate correction, higher urinary levels manganese, nickel, aluminum, rubidium, gallium, summary score only significantly lower MDI scores. The weighted quantile sum metal mixture showed a significant inverse association PDI scores, aluminum contributing most associations. Histidine, beta-alanine, purine, pyrimidine metabolism mediated above associations, suggesting that disturbances amino acids, neurotransmitter neuroendocrine may be important mediators children. linked underlying are unclear. Here, authors show neurotransmitters, mediate association.

Language: Английский

Citations

1
E-WASTE threatens health: The scientific solution adopts the one health strategy DOI
Chiara Frazzoli, Flavia Ruggieri, Beatrice Battistini

et al.

Environmental Research, Journal Year: 2022, Volume and Issue: 212, P. 113227 - 113227

Published: April 2, 2022

Language: Английский

Citations

36
Prenatal Diet as a Modifier of Environmental Risk Factors for Autism and Related Neurodevelopmental Outcomes DOI
Megan G. Bragg, Jorge E. Chavarro, Ghassan B. Hamra

et al.

Current Environmental Health Reports, Journal Year: 2022, Volume and Issue: 9(2), P. 324 - 338

Published: March 19, 2022

Language: Английский

Citations

23
Heavy Metals in Umbilical Cord Blood: Effects on Epigenetics and Child Development DOI Creative Commons
Sudipta Dutta, Douglas M. Ruden

Cells, Journal Year: 2024, Volume and Issue: 13(21), P. 1775 - 1775

Published: Oct. 26, 2024

Heavy metals like arsenic, mercury, cadmium, and lead are harmful pollutants that can change how our genes regulated without altering the DNA sequence, specifically through a process called methylation (DNAm) at 5-methylcytosine, an epigenetic mark we will focus on in this review. These changes DNAm most sensitive during pregnancy, critical time for development when these modifications affect traits expressed. Historically, research environmental effects has focused adults, but now there is more emphasis studying impacts early childhood. The placenta acts as protective barrier between mother baby, by examining it, scientists identify key might long-term health. This review looks exposure to heavy pregnancy cause gene regulation newborns, seen their umbilical cord blood. reflect baby’s genetic state be influenced mother’s environment genetics, well own genetics.

Language: Английский

Citations

5
DNA damage resulting from human endocrine disrupting chemical exposure: Genotoxicity, detection and dietary phytochemical intervention DOI
Xiaoqing Li,

Ningzi Zang,

Nan Zhang

et al.

Chemosphere, Journal Year: 2023, Volume and Issue: 338, P. 139522 - 139522

Published: July 19, 2023

Language: Английский

Citations

12
Prenatal exposures to phthalates and bisphenols in relation to oxidative stress: single pollutant and mixtures analyses DOI

Jia-Yue Zeng,

Min Zhang, Xuhui Chen

et al.

Environmental Science and Pollution Research, Journal Year: 2024, Volume and Issue: 31(9), P. 13954 - 13964

Published: Jan. 24, 2024

Language: Английский

Citations

4
Prenatal exposure to barium and arsenic and the odds of congenital heart defects in offspring: a nested case–control study within a birth cohort in Lanzhou, China DOI Creative Commons
Yun Dang,

Jianhao Sun,

Zhenzhen Wu

et al.

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 13

Published: May 1, 2025

Background Previous studies have identified that exposure to heavy metals increases the prevalence of congenital heart defects (CHDs); however, limited information exists regarding association between combined barium (Ba) and arsenic (As), CHDs. This study aims investigate prenatal Ba As (both independently in combination) risk CHDs offspring. Methods In a birth cohort conducted Lanzhou, China, total 97 mother-newborn pairs were designated as case group, with an additional 194 constituting control group. The concentrations maternal blood quantified utilizing inductively coupled plasma mass spectrometer. A multivariate logistic regression model was employed examine levels neonatal their subtypes. Interaction effects further evaluated through application both additive multiplicative models. Results concentration pregnant women is positively correlated levels. Higher level associated greater odds ( p = 0.008), including isolated 0.013), multiple 0.032), PDA 0.014), ASDs 0.031); Similarly, higher 0.016), 0.003), 0.005), 0.017), AVSDs 0.034). Elevated significantly increased subtypes offspring (All < 0.05). Furthermore, significant interaction relation 0.04). Conclusion Exposure or individually, well both,

Language: Английский

Citations

0
Epigenetics as a Biomarker for Early-Life Environmental Exposure DOI
Rose Schrott, Ashley Song, Christine Ladd‐Acosta

et al.

Current Environmental Health Reports, Journal Year: 2022, Volume and Issue: 9(4), P. 604 - 624

Published: July 30, 2022

Language: Английский

Citations

16
Does the Micronutrient Molybdenum Have a Role in Gestational Complications and Placental Health? DOI Open Access
Vladimira Foteva, Joshua J. Fisher, Yixue Qiao

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(15), P. 3348 - 3348

Published: July 27, 2023

Molybdenum is an essential trace element for human health and survival, with molybdenum-containing enzymes catalysing multiple reactions in the metabolism of purines, aldehydes, sulfur-containing amino acids. Recommended daily intakes vary globally, molybdenum primarily sourced through diet, supplementation not common. Although benefits as anti-diabetic antioxidant inducer have been reported literature, there are conflicting data on chronic diseases. Overexposure deficiency can result adverse outcomes mortality, although physiological doses remain largely unexplored relation to health. The lack knowledge surrounding intake role it plays physiology compounded during pregnancy. As pregnancy progresses, micronutrient demand increases, diet established factor programming gestational maternal This review summarises current literature concerning varied recommendations intake, molybdoenzymes physiology, contribution these play outcomes.

Language: Английский

Citations

10