ACS Applied Bio Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 7, 2025
Interferon-gamma
(IFN-γ),
an
essential
inflammatory
cytokine,
is
intricately
associated
with
a
variety
of
fatal
diseases
as
key
early
biomarker.
In
this
work,
we
designed
and
constructed
electrochemical
aptasensor
based
on
topological
insulator
Bi2Se3
sheets.
Micron-scale
sheets
were
prepared
by
exfoliation
from
single
crystals
to
make
electrodes
the
aptasensors.
The
unique
robust
Dirac
surface
states
could
enhance
charge
transfer
efficiency
solid-liquid
interface,
improving
performance
developed
exhibits
linear
response
IFN-γ
concentration
in
range
1-100
pg/mL
detection
limit
low
0.6
pg/mL,
enabling
it
meet
clinical
requirements.
aptasensors
also
shows
excellent
stability
selectivity.
Furthermore,
was
applied
human
serum
comparable
standard
enzyme-linked
immunosorbent
assay
technique.
Our
work
indicates
that
has
great
potential
for
application
other
possible
biomarkers.
ACS Applied Engineering Materials,
Год журнала:
2024,
Номер
2(2), С. 262 - 285
Опубликована: Янв. 25, 2024
Amid
global
concerns
over
water
scarcity
and
escalating
environmental
pollution,
there
has
been
a
surge
in
research
innovation
for
pioneering
wastewater
purification
technologies.
Advanced
micro
nanomanufacturing
methods
emerge
as
promising
avenues
to
enhance
conventional
treatment
efficiency.
This
review
guides
readers
through
recent
advancements,
merging
precision
engineering
at
micro/nanoscales
with
intricacies,
yielding
transformative
solutions.
Exploring
lithography-based
techniques,
additive
manufacturing,
self-assembly,
microfluidics,
it
uncovers
diverse
approaches
crafting
materials
interact
neutralize
pollutants.
The
manuscript
navigates
the
fusion
of
micro/nanomanufacturing
urgent
need
clean
water.
By
showcasing
empowered
surpassing
traditional
treatment,
tackles
expanding
pollutant
challenges.
Beyond
compiling
breakthroughs,
this
seeks
inspire
future
by
illuminating
how
manufacturing
can
address
holding
potential
combat
safeguard
ecosystems
generations.
Biosensors and Bioelectronics,
Год журнала:
2024,
Номер
263, С. 116632 - 116632
Опубликована: Авг. 3, 2024
Microfluidic
devices
are
increasingly
widespread
in
the
literature,
being
applied
to
numerous
exciting
applications,
from
chemical
research
Point-of-Care
devices,
passing
through
drug
development
and
clinical
scenarios.
Setting
up
these
microenvironments,
however,
introduces
necessity
of
locally
controlling
variables
involved
phenomena
under
investigation.
For
this
reason,
literature
has
deeply
explored
possibility
introducing
sensing
elements
investigate
physical
quantities
biochemical
concentration
inside
microfluidic
devices.
Biosensors,
particularly,
well
known
for
their
high
accuracy,
selectivity,
responsiveness.
However,
signals
could
be
challenging
interpret
must
carefully
analysed
carry
out
correct
information.
In
addition,
proper
data
analysis
been
demonstrated
even
increase
biosensors'
mentioned
qualities.
To
regard,
machine
learning
algorithms
undoubtedly
among
most
suitable
approaches
undertake
job,
automatically
highlighting
biosensor
signals'
characteristics
at
best.
Interestingly,
it
was
also
benefit
themselves,
a
new
paradigm
that
is
starting
name
"intelligent
microfluidics",
ideally
closing
benefic
interaction
disciplines.
This
review
aims
demonstrate
advantages
triad
microfluidics-biosensors-machine
learning,
which
still
little
used
but
great
perspective.
After
briefly
describing
single
entities,
different
sections
will
benefits
dual
interactions,
applications
where
reviewed
employed.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2023,
Номер
11
Опубликована: Апрель 27, 2023
Microfluidics
is
an
interdisciplinary
field
that
encompasses
both
science
and
engineering,
which
aims
to
design
fabricate
devices
capable
of
manipulating
extremely
low
volumes
fluids
on
a
microscale
level.
The
central
objective
microfluidics
provide
high
precision
accuracy
while
using
minimal
reagents
equipment.
benefits
this
approach
include
greater
control
over
experimental
conditions,
faster
analysis,
improved
reproducibility.
Microfluidic
devices,
also
known
as
labs-on-a-chip
(LOCs),
have
emerged
potential
instruments
for
optimizing
operations
decreasing
costs
in
various
industries,
including
pharmaceutical,
medical,
food,
cosmetics.
However,
the
price
conventional
prototypes
LOCs
generated
clean
room
facilities,
has
increased
demand
inexpensive
alternatives.
Polymers,
paper,
hydrogels
are
some
materials
can
be
utilized
create
microfluidic
covered
article.
In
addition,
we
highlighted
different
manufacturing
techniques,
such
soft
lithography,
laser
plotting,
3D
printing,
suitable
creating
LOCs.
selection
fabrication
techniques
will
depend
specific
requirements
applications
each
individual
LOC.
This
article
comprehensive
overview
numerous
alternatives
development
low-cost
service
industries
pharmaceuticals,
chemicals,
biomedicine.
Micromachines,
Год журнала:
2023,
Номер
14(8), С. 1520 - 1520
Опубликована: Июль 28, 2023
The
contamination
of
air,
water
and
soil
by
heavy
metal
ions
is
one
the
most
serious
problems
plaguing
environment.
These
are
characterized
a
low
biodegradability
high
chemical
stability
can
affect
humans
animals,
causing
severe
diseases.
In
addition
to
typical
analysis
methods,
i.e.,
liquid
chromatography
(LC)
or
spectrometric
methods
(i.e.,
atomic
absorption
spectroscopy,
AAS),
there
need
for
development
inexpensive,
easy-to-use,
sensitive
portable
devices
detection
at
point
interest.
To
this
direction,
microfluidic
lab-on-chip
(LOC)
fabricated
with
novel
materials
scalable
microfabrication
have
been
proposed
as
promising
approach
realize
such
systems.
This
review
focuses
on
recent
advances
used
important
toxic
ions,
namely,
lead
(Pb),
mercury
(Hg),
arsenic
(As),
cadmium
(Cd)
chromium
(Cr)
ions.
Particular
emphasis
given
materials,
fabrication
realization
in
order
provide
complete
overview
existing
technology
well
limitations
challenges
that
should
be
addressed
improve
commercial
uptake
LOC
environmental
monitoring
applications.
