Journal of Modern Agriculture and Biotechnology,
Год журнала:
2024,
Номер
3, С. 6 - 6
Опубликована: Авг. 22, 2024
Objective:
This
study
was
conducted
to
determined
the
effect
accelerated
storage
procedure
on
fungicide
stability,
as
well
as,
evaluate
impact
of
sub
lethal
doses
tested
fungicides
reproductive
and
liver
in
male
albino
rats.
Methods:
Determine
at
54±2℃
for
3,
7,
14
21
days
stability
azoxystrobin.
Investigate
effects
chronic
exposure
histopathological
examination
liver.
Results:
Azoxystrobin
were
relatively
stable
after
days.
The
mediam
dose
(LD50)
azoxystrobin
681.71mg/kg.
Azoxytrobin
25%
induced
a
significantly
decreased
sperm
count
motility
percent
1/20
1/40
LD50.The
serum
LH
FSH
levels
with
increasing
There
no
alteration
occurred
treated
LD50.
ALT
AST
enzymes
increased
(7.75
&.36.58U/L)
(4.39
&15.23U/L)
LD50,
also,
cholesterol
triglycerides
recoding
(116.01
&184.89mg/dL)
(110.18
&138.24mg/dL)
respectively.
rats
LD50
displayed
massive
inflammatory
cells
aggregation.
Conclusion:
high
levels,
enzymes,
Ecotoxicology and Environmental Safety,
Год журнала:
2024,
Номер
272, С. 116023 - 116023
Опубликована: Янв. 30, 2024
An
in
vivo
model
is
necessary
for
toxicology.
This
review
analyzed
the
uses
of
zebrafish
(Danio
rerio)
toxicology
based
on
bibliometrics.
Totally
56,816
publications
about
from
2002
to
2023
were
found
Web
Science
Core
Collection,
with
Toxicology
as
top
6
among
all
disciplines.
Accordingly,
bibliometric
map
reveals
that
"toxicity"
has
become
a
hot
keyword.
It
further
most
common
exposure
types
include
acute,
chronic,
and
combined
exposure.
The
toxicological
effects
behavioral,
intestinal,
cardiovascular,
hepatic,
endocrine
toxicity,
neurotoxicity,
immunotoxicity,
genotoxicity,
reproductive
transgenerational
toxicity.
mechanisms
oxidative
stress,
inflammation,
autophagy,
dysbiosis
gut
microbiota.
toxicants
commonly
evaluated
by
using
nanomaterials,
arsenic,
metals,
bisphenol,
dioxin.
Overall,
provide
unique
well-accepted
investigate
mechanisms.
We
also
discussed
possible
ways
address
some
limitations
model,
such
combination
human
organoids
avoid
species
differences.
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Март 16, 2025
Today,
pesticides
are
widely
used
to
enhance
agricultural
yield
mixed
with
soil
and
water,
creating
significant
environmental
pollution.
The
extensive
use
of
insecticides
for
pest
control
has
made
this
issue
more
pronounced.
Abamectin,
a
key
member
the
avermectin
family,
is
as
an
insecticide
antihelminthic
agent
in
agriculture.
It
active
effective
pesticide,
particularly
preferred
combating
pests
such
aphids
red
spider
mites.
dosage
frequency
its
vary
depending
on
target
plant
species
organism.
For
example,
abamectin-based
products
18
g/L
EC
formulation
apple
orchards
typically
recommended
at
10
ml/100
L
water
Although
significantly
below
application
levels,
low
dose
0.75
µg
L⁻1
our
study
demonstrated
effects
that
cannot
be
overlooked.
However,
it
can
contaminate
aquatic
environments,
posing
harmful
organisms.
Studies
indicate
abamectin
exposure
may
lead
serious
health
issues,
showing
toxic
reproductive
toxicity
species.
Examining
abamectin's
testicular
tissue
revealed
hypertrophy
Sertoli
cells
group
exposed
abamectin.
Apoptotic
were
observed
groups
1.5
L⁻1.
At
same
time,
pyknotic
structures,
disruption
seminiferous
tubules,
interstitial
fibrosis,
atrophic
appearance
identified
across
all
groups,
severity
increasing
dose-dependently.
Analysis
ovarian
distortion
zona
radiata
Moreover,
thickening
radiata,
vacuolization,
formation
degenerated
follicles,
nuclear
observed,
these
pathological
alterations
exacerbating
dose-dependent
manner.
Like
many
studies
involving
zebrafish,
research
crucial
assessing
potential
pose
risks
human
health.
This
examined
histopathological
varying
doses
(0.75
L⁻1,
3
L⁻1)
zebrafish
gonads
after
96
h
exposure.
Using
standard
histological
techniques,
samples
prepared
stained
H&E
under
light
microscope.
Statistical
analyses
conducted
using
SPSS
23.
normality
data
was
assessed
Shapiro–Wilk
test.
One-way
ANOVA
Tukey
post-hoc
tests
normally
distributed
while
Kruskal–Wallis
Dunnett's
T3
applied
non-normally
groups.
All
performed
95%
confidence
interval
significance
level
p
>
0.05.
Environment & Health,
Год журнала:
2024,
Номер
2(7), С. 424 - 440
Опубликована: Май 4, 2024
Triclosan
(TCS)
has
garnered
significant
attention
due
to
its
widespread
use
and
associated
endocrine-disrupting
effects.
However,
impact
on
the
neuroendocrine
system
underlying
mechanisms
remain
poorly
understood.
Here,
we
established
correlations
between
TCS
exposure
serum
sex
hormone
levels
in
participants
of
National
Health
Nutrition
Examination
Survey
(NHANES).
Additionally,
investigated
TCS's
influence
using
adult
zebrafish
exposed
environmentally
relevant
concentrations
(0.361–48.2
μg/L)
for
21
days.
Assessment
reproductive
neurotoxicity
included
histopathological
examination
behavioral
tests.
Transcriptomics,
proteomics
analyses,
biochemical
detection
were
employed
elucidate
TCS-induced
disruption.
Significant
found
estradiol,
testosterone,
hormone-binding
globulin
NHANES
participants.
In
addition,
inhibited
ovary
development
spermatogenesis
zebrafish.
Transcriptomics
analysis
revealed
gender-specific
key
signaling
metabolism-related
pathways
implicated
toxicity.
Moreover,
induced
nervous
impairment,
as
evidenced
by
histological
changes
altered
motor
behavior,
possibly
with
oxidative
damage.
Correlation
further
highlighted
potential
connection
endocrine
disruption
impairment
following
exposure.
Overall,
this
study
provided
evidence
supporting
offered
insights
into
mechanisms.
