Ecotoxicology and Environmental Safety,
Journal Year:
2024,
Volume and Issue:
283, P. 116969 - 116969
Published: Aug. 30, 2024
Novel
Psychoactive
Substances
(NPS)
derived
from
tryptamines
has
been
detected
in
aquatic
environments,
leading
to
environmental
toxicology
concerns.
However,
the
specific
toxicological
mechanism,
underlying
these
NPS,
remains
unclear.
In
our
previous
work,
we
used
5-Methoxy-N-isopropyl-N-methyltryptamine
(5-MeO-MiPT)
as
representative
drug
for
and
found
that,
5-MeO-MiPT
led
obvious
behavioral
inhibition
oxidative
stress
responses
zebrafishes
model.
this
study,
Zebrafish
were
injected
with
varying
concentrations
of
30
days.
RNA-seq,
qPCR,
metabolomics,
histopathological
analyses
conducted
assess
gene
expression
tissue
integrity.
This
study
confirms
that
substantially
influences
transcription
13
selected
genes,
including
ucp1,
pet100,
grik3,
grik4,
mediated
by
Gα
Ecotoxicology and Environmental Safety,
Journal Year:
2024,
Volume and Issue:
272, P. 116023 - 116023
Published: Jan. 30, 2024
An
in
vivo
model
is
necessary
for
toxicology.
This
review
analyzed
the
uses
of
zebrafish
(Danio
rerio)
toxicology
based
on
bibliometrics.
Totally
56,816
publications
about
from
2002
to
2023
were
found
Web
Science
Core
Collection,
with
Toxicology
as
top
6
among
all
disciplines.
Accordingly,
bibliometric
map
reveals
that
"toxicity"
has
become
a
hot
keyword.
It
further
most
common
exposure
types
include
acute,
chronic,
and
combined
exposure.
The
toxicological
effects
behavioral,
intestinal,
cardiovascular,
hepatic,
endocrine
toxicity,
neurotoxicity,
immunotoxicity,
genotoxicity,
reproductive
transgenerational
toxicity.
mechanisms
oxidative
stress,
inflammation,
autophagy,
dysbiosis
gut
microbiota.
toxicants
commonly
evaluated
by
using
nanomaterials,
arsenic,
metals,
bisphenol,
dioxin.
Overall,
provide
unique
well-accepted
investigate
mechanisms.
We
also
discussed
possible
ways
address
some
limitations
model,
such
combination
human
organoids
avoid
species
differences.
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: March 16, 2025
Today,
pesticides
are
widely
used
to
enhance
agricultural
yield
mixed
with
soil
and
water,
creating
significant
environmental
pollution.
The
extensive
use
of
insecticides
for
pest
control
has
made
this
issue
more
pronounced.
Abamectin,
a
key
member
the
avermectin
family,
is
as
an
insecticide
antihelminthic
agent
in
agriculture.
It
active
effective
pesticide,
particularly
preferred
combating
pests
such
aphids
red
spider
mites.
dosage
frequency
its
vary
depending
on
target
plant
species
organism.
For
example,
abamectin-based
products
18
g/L
EC
formulation
apple
orchards
typically
recommended
at
10
ml/100
L
water
Although
significantly
below
application
levels,
low
dose
0.75
µg
L⁻1
our
study
demonstrated
effects
that
cannot
be
overlooked.
However,
it
can
contaminate
aquatic
environments,
posing
harmful
organisms.
Studies
indicate
abamectin
exposure
may
lead
serious
health
issues,
showing
toxic
reproductive
toxicity
species.
Examining
abamectin's
testicular
tissue
revealed
hypertrophy
Sertoli
cells
group
exposed
abamectin.
Apoptotic
were
observed
groups
1.5
L⁻1.
At
same
time,
pyknotic
structures,
disruption
seminiferous
tubules,
interstitial
fibrosis,
atrophic
appearance
identified
across
all
groups,
severity
increasing
dose-dependently.
Analysis
ovarian
distortion
zona
radiata
Moreover,
thickening
radiata,
vacuolization,
formation
degenerated
follicles,
nuclear
observed,
these
pathological
alterations
exacerbating
dose-dependent
manner.
Like
many
studies
involving
zebrafish,
research
crucial
assessing
potential
pose
risks
human
health.
This
examined
histopathological
varying
doses
(0.75
L⁻1,
3
L⁻1)
zebrafish
gonads
after
96
h
exposure.
Using
standard
histological
techniques,
samples
prepared
stained
H&E
under
light
microscope.
Statistical
analyses
conducted
using
SPSS
23.
normality
data
was
assessed
Shapiro–Wilk
test.
One-way
ANOVA
Tukey
post-hoc
tests
normally
distributed
while
Kruskal–Wallis
Dunnett's
T3
applied
non-normally
groups.
All
performed
95%
confidence
interval
significance
level
p
>
0.05.
Environment & Health,
Journal Year:
2024,
Volume and Issue:
2(7), P. 424 - 440
Published: May 4, 2024
Triclosan
(TCS)
has
garnered
significant
attention
due
to
its
widespread
use
and
associated
endocrine-disrupting
effects.
However,
impact
on
the
neuroendocrine
system
underlying
mechanisms
remain
poorly
understood.
Here,
we
established
correlations
between
TCS
exposure
serum
sex
hormone
levels
in
participants
of
National
Health
Nutrition
Examination
Survey
(NHANES).
Additionally,
investigated
TCS's
influence
using
adult
zebrafish
exposed
environmentally
relevant
concentrations
(0.361–48.2
μg/L)
for
21
days.
Assessment
reproductive
neurotoxicity
included
histopathological
examination
behavioral
tests.
Transcriptomics,
proteomics
analyses,
biochemical
detection
were
employed
elucidate
TCS-induced
disruption.
Significant
found
estradiol,
testosterone,
hormone-binding
globulin
NHANES
participants.
In
addition,
inhibited
ovary
development
spermatogenesis
zebrafish.
Transcriptomics
analysis
revealed
gender-specific
key
signaling
metabolism-related
pathways
implicated
toxicity.
Moreover,
induced
nervous
impairment,
as
evidenced
by
histological
changes
altered
motor
behavior,
possibly
with
oxidative
damage.
Correlation
further
highlighted
potential
connection
endocrine
disruption
impairment
following
exposure.
Overall,
this
study
provided
evidence
supporting
offered
insights
into
mechanisms.
Redox Report,
Journal Year:
2024,
Volume and Issue:
29(1)
Published: Nov. 14, 2024
The
fungicides
strobilurins
and
succinate
dehydrogenase
inhibitors
(SDHIs)
are
blockers
of
the
electron
transport
chain
(ETC)
in
fungi.
Here,
we
show
that
exposure
for
24
h
to
kresoxym-methyl,
a
fungicide
from
class
strobilurins,
alters
mitochondrial
respiration
human
HepG2
hepatocytes.
In
addition,
demonstrate
an
increase
production
superoxide
radical
anion,
reduction
ATP
level,
decrease
ratio
reduced/oxidized
glutathione
cell
viability
(assessed
by
LDH
assay,
Presto
Blue
Crystal
Violet
assay).
As
kresoxym-methyl
is
associated
boscalid
(SDHI)
commercial
formulations,
analyzed
potential
exacerbation
induced
dysfunction
this
combination.
For
highest
dose
at
which
(5
µM)
(0.5
did
not
induce
changes
function
when
used
separately,
contrast,
both
were
combination
same
concentration,
observed
significant
alteration
hepatocytes:
there
was
oxygen
consumption
rate,
level.
level
anion
increased
leading
glutathione,
viability.
