Nano and Microplastics: Unveiling Their Profound Impact on Endocrine Health DOI
Faezeh Jahedi,

Neamatollah Jaafarzadeh Haghighi Fard,

Mohammad Ali Khaksar

и другие.

Toxicology Mechanisms and Methods, Год журнала: 2025, Номер unknown, С. 1 - 47

Опубликована: Май 28, 2025

Plastics are extensively used materials with a long environmental lifespan, posing significant risks to human health and the environment. Global plastic consumption has surged, waste expected triple by 2060. The primary concern is breakdown of plastics into nano micro-sized particles, which can enter body have been detected in various organs tissues.This review systematically examines effects micro nanoplastics (MNPs) on endocrine system using vitro vivo experimental models. Following PRISMA guidelines, articles were sourced from databases like PubMed, Web Science, Scopus. After screening for relevance removing duplicates non-English articles, 103 focusing MNPs selected.MNPs disrupt functions, altering reproductive hormones gene expression patterns. In exposure increases inflammatory markers such as TNF-α, IL-6, IL-1β, NF-κB, leading apoptosis, inflammation, oxidative stress. These disruptions impact gonads, thyroid glands, hormone secretion pituitary hypothalamus. Most studies focus terrestrial animals, polystyrene being most commonly polymer.Future research should explore polymers, longer durations, broader range concentrations, human-level better understand toxicity particles. Reducing these pollutants requires legal changes, consumer behavior adjustments, increased public awareness. Understanding underlying processes help propose methods mitigate protect health.

Язык: Английский

Reproductive Effects of Phthalates and Microplastics on Marine Mussels Based on Adverse Outcome Pathway DOI

Xukai Lan,

Xiaopeng Pang, Karsoon Tan

и другие.

Environmental Science & Technology, Год журнала: 2025, Номер unknown

Опубликована: Март 18, 2025

Microplastic pollution has emerged as a global environmental concern. As filter-feeding organisms, marine mussels are particularly vulnerable to microplastics. Moreover, phthalic acid esters (PAEs) known leach from microplastics under various conditions. Among PAEs, bis(2-ethylhexyl) phthalate (DEHP) is common endocrine disruptor. We investigated the effects of and plasticizers on reproductive function female mussel Mytilus coruscus. The results revealed that exposure DEHP high-density polyethylene (HDPE) triggered molecular changes by allowing act an antiestrogen binding with estrogen receptors (ER), thereby constituting initiating event. Key events were suppression ER, cytochrome P450-3 (CYP3), 17β-hydroxysteroid dehydrogenase (17β-HSD) gene expressions, which reduced estradiol progesterone levels in ovarian tissues. Ultimately adverse outcomes occurred: antioxidant capacity tissue was impaired, hindering development reducing function. This study introduces novel outcome pathway (AOP) framework focusing impairment shellfish. By integrating experimental findings AOP concept, research provides essential data for understanding toxicological microplastic pollutants mussels. offers valuable insights risk assessment, contributing better how threaten life.

Язык: Английский

Процитировано

2
Synergistic endocrine disruption and cellular toxicity of polyethylene microplastics and bisphenol A in MLTC-1 cells and zebrafish DOI Creative Commons

Ting Ye,

R.S.H. Yang,

Sarles He

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Март 28, 2025

The study investigates the synergistic endocrine disruption and cellular toxicity resulting from co-exposure to polyethylene microplastics (PE-MPs) bisphenol A (BPA) in zebrafish MLTC-1 cells. Previous research has extensively examined individual effects of PE-MPs BPA on systems health. However, specific interactions combined toxicological impacts these two common environmental pollutants remain underexplored, particularly terms their pathways viability. To fill this knowledge gap, we characterized using scanning electron microscopy Raman spectrometry exposed cells PE-MPs, BPA, or combinations both. results showed that 100 µg/mL 100-150 µmol/L for 48 h significantly decreased cell viability, increased apoptosis rates, induced G2/M cycle arrest, reduced mitochondrial membrane potential, altered transcriptional expression genes related steroidogenesis. Specifically, upregulated Ar while downregulating Lhr 3β-Hsd, with being more pronounced than those observed single exposures. In a complementary vivo study, adult were environmentally relevant concentrations (1 mg/L) (1.5 µg/L) 28 days. This resulted significant increases GSI alterations gene associated HPG axis. male brains, such as Gnrh2, Esr1, downregulated, female Gnrh3, also exhibited downregulation. testes, Star, Cyp11a1, Hsd11b2 upregulated, whereas Cyp19a1a, Hsd3b, Hsd20b, Hsd17b3 downregulated. contrast, ovaries upregulation Cyp17, Cyp11b, Hsd17b3, Cyp19a1a was indicating sex-specific disruption. Overall, findings reveal induces toxic both vitro vivo, which underscores importance studying better assess health risks.

Язык: Английский

Процитировано

1
Microplastics bioaccumulation in fish: its potential toxic effects on hematology, immune response, neurotoxicity, oxidative stress, growth and reproductive dysfunction DOI Creative Commons
Tapas Ghosh

Toxicology Reports, Год журнала: 2024, Номер 14, С. 101854 - 101854

Опубликована: Дек. 10, 2024

Язык: Английский

Процитировано

7
Toxicity of polyvinyl chloride microplastics on Brassica rapa DOI
Hao Wu, Beibei He,

Bocheng Chen

и другие.

Environmental Pollution, Год журнала: 2023, Номер 336, С. 122435 - 122435

Опубликована: Авг. 23, 2023

Язык: Английский

Процитировано

16
Behaviour, a potential bioindicator for toxicity analysis of waterborne microplastics: A review DOI
Lin Huang, Weixia Zhang,

Weishang Zhou

и другие.

TrAC Trends in Analytical Chemistry, Год журнала: 2023, Номер 162, С. 117044 - 117044

Опубликована: Апрель 1, 2023

Язык: Английский

Процитировано

15
Unveiling the Microplastic Crisis: Insights into Bangladesh's Aquatic Ecosystems - Origins, Impact, and Solutions DOI Creative Commons
Md. Abu Kawsar, Fatema Jannat Munny, Uddin Md Saif

и другие.

Journal of Hazardous Materials Advances, Год журнала: 2024, Номер 14, С. 100430 - 100430

Опубликована: Апрель 28, 2024

Microplastics (MPs) are an increasingly concerning type of environmental pollutant due to their abundance and the potential for bioaccumulation in aquatic food organisms. The presence MPs natural waters is a clear indication incorrect disposal plastic debris rapid growth synthetic production. An inclusive understanding sources, transportation, fate, consequences waste crucial accurately estimating global transit pollution reducing its sources hazards. Bangladesh significant contributor pollution, this review aims summarize existing knowledge research gap on MP ecosystems over past five years. This article discusses features, occurrence, hazardous effects organisms humans provide innovative approaches sustainable remediation. It emphasizes importance multidisciplinary approach inputs into environment, including regulation production consumption plastics, using bio-based biodegradable improving plastics life cycle, eco-friendly design production, extended producer accountability management, prioritizing recycling, creating demand recycled collection management systems. study purposes further Bangladesh, explore environmentally friendly substitutes, decision-makers with effective strategies address problem Bangladesh.

Язык: Английский

Процитировано

5
Reproductive and developmental implications of micro- and nanoplastic internalization: Recent advances and perspectives DOI Creative Commons
Zitong Zhang,

Jiahua Meng,

Jiaqi Tian

и другие.

Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 286, С. 117245 - 117245

Опубликована: Окт. 25, 2024

Язык: Английский

Процитировано

5
Mitigative potential of kaempferide against polyethylene microplastics induced testicular damage by activating Nrf-2/Keap-1 pathway DOI Creative Commons
Muhammad Umar Ijaz,

Zainab Rafi,

Ali Hamza

и другие.

Ecotoxicology and Environmental Safety, Год журнала: 2023, Номер 269, С. 115746 - 115746

Опубликована: Ноя. 29, 2023

Polyethylene microplastics (PE-MPs) are one of the environmental contaminants that instigate oxidative stress (OS) in various organs body, including testes. Kaempferide (KFD) is a plant-derived natural flavonol with potential neuroprotective, hepatoprotective, anti-cancer, anti-oxidant and anti-inflammatory properties. Therefore, present study was designed to evaluate alleviative effects KFD against PE-MPs-prompted testicular toxicity rats. Fourty eight adult male albino rats were randomly distributed into 4 groups: control, PE-MPs-administered (1.5 mgkg

Язык: Английский

Процитировано

11
Zebrafish neuromast sensory system: Is it an emerging target to assess environmental pollution impacts? DOI

Felipe Cirqueira,

Lívia Pitombeira de Figueirêdo, Guilherme Malafaia

и другие.

Environmental Pollution, Год журнала: 2024, Номер 344, С. 123400 - 123400

Опубликована: Янв. 23, 2024

Язык: Английский

Процитировано

4
Association of diet and lifestyle factors with semen quality in male partners of Chinese couples preparing for pregnancy DOI Creative Commons
Hanran Mai,

Junyi Ke,

Zilin Zheng

и другие.

Reproductive Health, Год журнала: 2023, Номер 20(1)

Опубликована: Ноя. 23, 2023

Abstract Background Semen quality significantly influences conception, and its preservation is crucial for couples seeking pregnancy. We investigated dietary lifestyle risk factors impacting semen quality. Methods A total of 466 males from the Guangzhou Women Children’s Medical Center’s pre-pregnancy consultation clinic were recruited between January 2021 March 2023 inclusion. analysis was performed, diet data gathered via questionnaire. Logistic regression utilized to examine link diet, variables, Results Smoking worsened progressive sperm motility (38.0% vs. 36.0%, t = 2.262; P 0.049). Alcohol consumption impaired (40.5 ± 17.8% 34.7 16.1%, 3.396; < 0.001) (56.0% 64.0%; 0.001). Using plastic beverage bottles oil or seasonings lowered concentrations (40.4% 59.0% 65.5%; 0.032). sweet correlated with higher (55.0% 60.0%, 62.0% 63.2%; 0.017). Higher milk product intake improved concentration (41.6 10 6 63.7 66.1*10 ; 0.021) (54.5% 56.0% 63.0%; 0.033). More frequent egg increased volume (3.1 mL 3.8 4.0 mL; 0.038). Roughage enhanced (160.8 224.6 0.027), adequate sleep rate (35.4% 18.2% 40.2 16.3%, F 3.747; 0.024) (52.7% 61.5%; 0.013). The model showed that using containers condiments a protective factor (OR: 0.12; CI 0.03–0.55; 0.006), 0.001, 0.00–0.30; 0.012), count 0.12, 0.03–0.48; 0.003). Milk also 0.18, 0.06–0.51; 0.001 OR: 0.11, 0.006, respectively), while sufficient benefitted 0.47, 0.24–0.95; 0.034). Conclusions drinking, type condiment container, preference, duration, milk, roughage, may reduce

Язык: Английский

Процитировано

9