Toxicology Mechanisms and Methods,
Год журнала:
2025,
Номер
unknown, С. 1 - 47
Опубликована: Май 28, 2025
Plastics
are
extensively
used
materials
with
a
long
environmental
lifespan,
posing
significant
risks
to
human
health
and
the
environment.
Global
plastic
consumption
has
surged,
waste
expected
triple
by
2060.
The
primary
concern
is
breakdown
of
plastics
into
nano
micro-sized
particles,
which
can
enter
body
have
been
detected
in
various
organs
tissues.This
review
systematically
examines
effects
micro
nanoplastics
(MNPs)
on
endocrine
system
using
vitro
vivo
experimental
models.
Following
PRISMA
guidelines,
articles
were
sourced
from
databases
like
PubMed,
Web
Science,
Scopus.
After
screening
for
relevance
removing
duplicates
non-English
articles,
103
focusing
MNPs
selected.MNPs
disrupt
functions,
altering
reproductive
hormones
gene
expression
patterns.
In
exposure
increases
inflammatory
markers
such
as
TNF-α,
IL-6,
IL-1β,
NF-κB,
leading
apoptosis,
inflammation,
oxidative
stress.
These
disruptions
impact
gonads,
thyroid
glands,
hormone
secretion
pituitary
hypothalamus.
Most
studies
focus
terrestrial
animals,
polystyrene
being
most
commonly
polymer.Future
research
should
explore
polymers,
longer
durations,
broader
range
concentrations,
human-level
better
understand
toxicity
particles.
Reducing
these
pollutants
requires
legal
changes,
consumer
behavior
adjustments,
increased
public
awareness.
Understanding
underlying
processes
help
propose
methods
mitigate
protect
health.
Environmental Science & Technology,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 18, 2025
Microplastic
pollution
has
emerged
as
a
global
environmental
concern.
As
filter-feeding
organisms,
marine
mussels
are
particularly
vulnerable
to
microplastics.
Moreover,
phthalic
acid
esters
(PAEs)
known
leach
from
microplastics
under
various
conditions.
Among
PAEs,
bis(2-ethylhexyl)
phthalate
(DEHP)
is
common
endocrine
disruptor.
We
investigated
the
effects
of
and
plasticizers
on
reproductive
function
female
mussel
Mytilus
coruscus.
The
results
revealed
that
exposure
DEHP
high-density
polyethylene
(HDPE)
triggered
molecular
changes
by
allowing
act
an
antiestrogen
binding
with
estrogen
receptors
(ER),
thereby
constituting
initiating
event.
Key
events
were
suppression
ER,
cytochrome
P450-3
(CYP3),
17β-hydroxysteroid
dehydrogenase
(17β-HSD)
gene
expressions,
which
reduced
estradiol
progesterone
levels
in
ovarian
tissues.
Ultimately
adverse
outcomes
occurred:
antioxidant
capacity
tissue
was
impaired,
hindering
development
reducing
function.
This
study
introduces
novel
outcome
pathway
(AOP)
framework
focusing
impairment
shellfish.
By
integrating
experimental
findings
AOP
concept,
research
provides
essential
data
for
understanding
toxicological
microplastic
pollutants
mussels.
offers
valuable
insights
risk
assessment,
contributing
better
how
threaten
life.
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Март 28, 2025
The
study
investigates
the
synergistic
endocrine
disruption
and
cellular
toxicity
resulting
from
co-exposure
to
polyethylene
microplastics
(PE-MPs)
bisphenol
A
(BPA)
in
zebrafish
MLTC-1
cells.
Previous
research
has
extensively
examined
individual
effects
of
PE-MPs
BPA
on
systems
health.
However,
specific
interactions
combined
toxicological
impacts
these
two
common
environmental
pollutants
remain
underexplored,
particularly
terms
their
pathways
viability.
To
fill
this
knowledge
gap,
we
characterized
using
scanning
electron
microscopy
Raman
spectrometry
exposed
cells
PE-MPs,
BPA,
or
combinations
both.
results
showed
that
100
µg/mL
100-150
µmol/L
for
48
h
significantly
decreased
cell
viability,
increased
apoptosis
rates,
induced
G2/M
cycle
arrest,
reduced
mitochondrial
membrane
potential,
altered
transcriptional
expression
genes
related
steroidogenesis.
Specifically,
upregulated
Ar
while
downregulating
Lhr
3β-Hsd,
with
being
more
pronounced
than
those
observed
single
exposures.
In
a
complementary
vivo
study,
adult
were
environmentally
relevant
concentrations
(1
mg/L)
(1.5
µg/L)
28
days.
This
resulted
significant
increases
GSI
alterations
gene
associated
HPG
axis.
male
brains,
such
as
Gnrh2,
Esr1,
downregulated,
female
Gnrh3,
also
exhibited
downregulation.
testes,
Star,
Cyp11a1,
Hsd11b2
upregulated,
whereas
Cyp19a1a,
Hsd3b,
Hsd20b,
Hsd17b3
downregulated.
contrast,
ovaries
upregulation
Cyp17,
Cyp11b,
Hsd17b3,
Cyp19a1a
was
indicating
sex-specific
disruption.
Overall,
findings
reveal
induces
toxic
both
vitro
vivo,
which
underscores
importance
studying
better
assess
health
risks.
Journal of Hazardous Materials Advances,
Год журнала:
2024,
Номер
14, С. 100430 - 100430
Опубликована: Апрель 28, 2024
Microplastics
(MPs)
are
an
increasingly
concerning
type
of
environmental
pollutant
due
to
their
abundance
and
the
potential
for
bioaccumulation
in
aquatic
food
organisms.
The
presence
MPs
natural
waters
is
a
clear
indication
incorrect
disposal
plastic
debris
rapid
growth
synthetic
production.
An
inclusive
understanding
sources,
transportation,
fate,
consequences
waste
crucial
accurately
estimating
global
transit
pollution
reducing
its
sources
hazards.
Bangladesh
significant
contributor
pollution,
this
review
aims
summarize
existing
knowledge
research
gap
on
MP
ecosystems
over
past
five
years.
This
article
discusses
features,
occurrence,
hazardous
effects
organisms
humans
provide
innovative
approaches
sustainable
remediation.
It
emphasizes
importance
multidisciplinary
approach
inputs
into
environment,
including
regulation
production
consumption
plastics,
using
bio-based
biodegradable
improving
plastics
life
cycle,
eco-friendly
design
production,
extended
producer
accountability
management,
prioritizing
recycling,
creating
demand
recycled
collection
management
systems.
study
purposes
further
Bangladesh,
explore
environmentally
friendly
substitutes,
decision-makers
with
effective
strategies
address
problem
Bangladesh.
Ecotoxicology and Environmental Safety,
Год журнала:
2023,
Номер
269, С. 115746 - 115746
Опубликована: Ноя. 29, 2023
Polyethylene
microplastics
(PE-MPs)
are
one
of
the
environmental
contaminants
that
instigate
oxidative
stress
(OS)
in
various
organs
body,
including
testes.
Kaempferide
(KFD)
is
a
plant-derived
natural
flavonol
with
potential
neuroprotective,
hepatoprotective,
anti-cancer,
anti-oxidant
and
anti-inflammatory
properties.
Therefore,
present
study
was
designed
to
evaluate
alleviative
effects
KFD
against
PE-MPs-prompted
testicular
toxicity
rats.
Fourty
eight
adult
male
albino
rats
were
randomly
distributed
into
4
groups:
control,
PE-MPs-administered
(1.5
mgkg