Toxics,
Год журнала:
2023,
Номер
11(12), С. 1000 - 1000
Опубликована: Дек. 7, 2023
Reproductive
disorders
are
considered
a
global
health
problem
influenced
by
physiological,
genetic,
environmental,
and
lifestyle
factors.
The
increased
exposure
to
bisphenols,
chemical
used
in
large
quantities
for
the
production
of
polycarbonate
plastics,
has
raised
concerns
regarding
risks
humans,
particularly
their
endocrine-disrupting
effects
on
female
reproductive
health.
To
provide
basis
future
research
environmental
interference
health,
we
reviewed
relevant
studies
patterns
levels
bisphenols
matrices
humans
(including
susceptible
populations
such
as
pregnant
women
children).
In
addition,
focused
Animals,
Год журнала:
2024,
Номер
14(2), С. 222 - 222
Опубликована: Янв. 10, 2024
In
recent
years,
bisphenol
AF
(BPAF)
in
aquatic
environments
has
drawn
attention
to
its
ecological
risks.
This
study
aims
investigate
the
toxic
effects
of
BPAF
(188.33
μg/L)
exposure
for
30
days
on
female
marine
medaka
(Oryzias
melastigma).
On
10th
and
30th
day
exposure,
toxicity
was
evaluated
using
histological
analysis
liver
ovaries
transcription
levels
genes
related
antioxidant
system,
immune
hypothalamic-pituitary-gonadal
(HPG)
axis.
Findings
revealed
that
(1)
caused
vacuolation,
karyopyknosis
karyolysis
medaka,
impact
augmented
with
duration;
(2)
10
facilitated
growth
maturation
primary
ova,
this
had
a
comparatively
inhibitory
effect
after
days;
(3)
resulted
biphasic
regulation
transcriptional
abundance
involved
inflammatory
response
(e.g.,
il-8,
cat),
an
initial
up-regulation
followed
by
down-regulation.
Additionally,
it
disrupted
pattern
HPG
axis-related
3βhsd,
arα).
conclusion,
188.33
μg/L
can
alter
expression
functionally
genes,
impair
structural
integrity
organisms,
pose
threat
their
overall
health.
