Human Reproduction,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 20, 2024
Abstract
The
extensive
use
of
bisphenols
in
the
plastics
industry
globally
is
a
major
growing
concern
for
human
health.
Bisphenol
compounds
are
easily
leached
out
from
plastic
containers
to
food,
beverages,
and
drinking
water
contaminate
natural
environment.
Daily
exposure
bisphenol
increases
their
load
impairs
various
organs,
including
reproductive
system.
directly
or
indirectly
affect
ovarian
functions,
such
as
folliculogenesis,
steroidogenesis,
oogenesis,
thereby
oocyte
quality.
A
(BPA)
its
structural
analogues
act
endocrine
disruptors
induce
generation
reactive
oxygen
species
(ROS)
within
ovary.
Excess
levels
ROS
death
pathways
follicular
steroidogenic
cells
steroidogenesis.
reduced
level
estradiol-17β
growth
development
that
reduces
number
quality
oocytes.
In
addition,
excess
fluid
trigger
meiotic
instability,
which
further
deteriorates
high
generates
oxidative
stress
triggers
germ
well
oocytes,
induces
atresia,
depletes
reserve.
Although
evidence
indicates
destructive
effects
at
ovary,
potential
underlying
mechanisms
deteriorate
remain
poorly
understood.
Therefore,
this
review
summarizes
by
cause
damage
impair
quality,
women's
fertility.
Reproductive Biology and Endocrinology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Ноя. 11, 2024
The
female
reproductive
system
can
face
serious
disorders
and
show
abnormalities
under
the
influence
of
environmental
pollutants.
Microplastics
(MPs)
nanoplastics
(NPs)
as
emerging
pollutants,
by
affecting
different
components
this
system,
may
make
fertility
a
challenge.
Animal
studies
have
demonstrated
that
exposure
to
these
substances
weakens
function
ovaries
causes
decrease
in
ovarian
reserve
capacity.
Also,
continuous
micro/nano
plastics
(MNPs)
leads
increased
levels
reactive
oxygen
species,
induction
oxidative
stress,
inflammatory
responses,
apoptosis
granulosa
cells,
reduction
number
follicles.
Furthermore,
interfering
with
hypothalamic-pituitary-ovarian
axis,
particles
disturb
normal
androgens
endocrine
balance
delay
growth
gonads.
Exposure
MNPs
accelerate
carcinogenesis
humans
animal
models.
determined
accumulate
placenta,
causing
metabolic
changes,
disrupting
development
fetus,
endangering
health
future
generations.
In
humans,
presence
micro/nanoplastics
placenta
tissue,
infant
feces,
breast
milk
has
been
reported.
These
directly
affect
mother
increasing
risk
premature
birth
other
pregnancy
complications.
This
review
aims
outline
hazardous
effects
on
fetal
discuss
results
experiments
human
research
focusing
cellular
molecular
pathways.
Biomolecules,
Год журнала:
2024,
Номер
14(5), С. 540 - 540
Опубликована: Апрель 30, 2024
Hydrogen
sulfide
(H2S),
previously
regarded
as
a
toxic
exhaust
and
atmospheric
pollutant,
has
emerged
the
third
gaseous
signaling
molecule
following
nitric
oxide
(NO)
carbon
monoxide
(CO).
Recent
research
revealed
significant
biological
effects
of
H2S
in
variety
systems,
such
nervous,
cardiovascular,
digestive
systems.
Additionally,
been
found
to
impact
reproductive
system
function
may
have
therapeutic
implications
for
disorders.
This
paper
explores
relationship
between
male
disorders,
specifically
erectile
dysfunction,
prostate
cancer,
infertility,
testicular
damage.
it
examines
regulation
on
pathophysiology
female
system,
including
improvements
preterm
birth,
endometriosis,
pre-eclampsia,
fetal
growth
restriction,
unexplained
recurrent
spontaneous
abortion,
placental
oxidative
damage,
embryo
implantation,
recovery
myometrium
post-delivery,
ovulation.
The
study
delves
into
regulatory
functions
within
systems
both
genders,
its
NO/cGMP
pathway,
activation
K+
channels,
relaxation
mechanism
spongy
smooth
muscle
through
ROCK
aiming
broaden
scope
potential
strategies
treating
disorders
clinical
settings.
Analytical and Bioanalytical Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 18, 2024
Abstract
Wastewater-based
epidemiology
(WBE)
is
a
powerful
tool
to
gather
epidemiological
insights
at
the
community
level,
providing
objective
data
on
population
exposure
harmful
substances.
A
considerable
portion
of
human
these
potentially
chemicals
occurs
unintentionally,
unlike
substances
such
as
pharmaceuticals,
illicit
drugs,
or
alcohol.
In
this
context,
comprehensive
review
analyzes
WBE
studies
focused
classes
organic
which
humans
are
unintentionally
exposed,
namely
organophosphorus
flame
retardants,
per-
and
polyfluoroalkyl
(PFAS),
benzotriazoles
benzothiazoles,
phthalates
terephthalates,
benzophenones,
pesticides,
bisphenols,
parabens.
The
highlights
some
advantages
for
public
health
surveillance,
e.g.,
non-invasive
analysis,
predictive
capability,
nearly
real-time
data,
population-wide
insights,
no
ethical
approval,
unbiased
sampling.
It
also
discusses
challenges
future
research
directions
in
regarding
from
various
sources.
emphasizes
critical
role
wastewater
sampling,
sample
preparation,
quality
control,
instrumental
analysis
achieving
accurate
reliable
results.
Furthermore,
it
examines
selection
biomarkers
explores
strategies
link
with
biomonitoring
(HBM),
together
enhance
both
precision
effectiveness
assessments.
Nutrients,
Год журнала:
2024,
Номер
16(21), С. 3740 - 3740
Опубликована: Окт. 31, 2024
Every
year
the
global
incidence
of
obesity
increases
considerably
and
among
factors
that
favor
it
is
bisphenol
A
(BPA),
an
endocrine
disruptor
widely
used
in
plastics
omnipresent
many
everyday
objects.
Journal of Xenobiotics,
Год журнала:
2025,
Номер
15(1), С. 26 - 26
Опубликована: Фев. 2, 2025
Infertility
affects
8–12%
of
couples
worldwide,
and
30–75%
preclinical
pregnancy
losses
are
due
to
a
failure
during
the
implantation
process.
Exposure
endocrine
disruptors,
like
bisphenols,
among
others,
has
been
associated
with
increase
in
infertility
observed
past
decades.
An
correlated
exposure
disruptors
bisphenols.
The
uterus
harbors
its
own
microbiota,
changes
this
microbiota
have
linked
several
gynecological
conditions,
including
reproductive
failure.
There
no
studies
on
effects
bisphenols
uterine–microbiota
composition,
but
some
inferences
can
be
gleaned
by
looking
at
gut.
Bisphenols
alter
gut
molecular
mechanism
which
regulates
intestinal
permeability
involves
Toll-like
receptors
(TLRs)
tight
junction
(TJ)
proteins.
TJs
participate
embryo
uterus,
bisphenol
disrupts
expression
localization
TJ
aim
review
is
summarize
current
knowledge
female
tract
(FRT),
association
different
diseases—particularly
failure—the
composition
health,
mechanisms
regulating
interactions
crucial
for
implantation.
This
also
highlights
existing
gaps
outlines
research
needs
future
risk
assessments
regarding
reproduction.
Endocrines,
Год журнала:
2025,
Номер
6(2), С. 23 - 23
Опубликована: Май 14, 2025
Background:
Plastic
pollution
driven
by
human
activities
has
become
a
critical
global
issue
for
health.
A
growing
literature
demonstrates
that
micro-
and
nanoplastics
(MNPs)
contain
endocrine-disrupting
chemicals
(EDCs)
other
harmful
compounds
enter
the
body
easily,
acting
as
agonists
or
antagonists
wide
range
of
hormonal
receptors,
promoting
endocrine
toxicity.
Endocrine
disruption
induced
MNPs
occurs
through
aberrant
activation/inhibition
different
signaling
pathways
in
addition
to
directly
interfering
with
balances,
trigger
apoptosis,
oxidative
stress,
inflammation
cells.
However,
date,
molecular
mechanisms
these
contaminants
remain
not
completely
elucidated.
Furthermore,
given
unanimous
consensus
on
negative
impact
health,
several
methodologies
have
been
developed
detect
only
environment
but
also
biological
fluids
tissues.
Results:
This
review
comprehensively
summarizes
emerging
experimental
clinical
evidence
explaining
underlying
toxicity
related
chronic
plastic
relation
system.
In
addition,
illustrates
new
methodological
approaches
samples,
highlighting
employing
complementary
methods
enables
precise
characterization
quantification
MNPs.
Conclusions:
Future
studies
experimental,
epidemiological,
epigenetic,
multi-omics
are
essential
understanding
short
long-term
effects
glands
developing
effective
strategies
mitigate
their
