Variations in the LINGO2 and GLIS3 Genes and Gene–Environment Interactions Increase Gestational Diabetes Mellitus Risk in Chinese Women DOI
Xiao Huang, Weiwei Liang,

Runqiu Yang

и другие.

Environmental Science & Technology, Год журнала: 2024, Номер 58(26), С. 11596 - 11605

Опубликована: Июнь 18, 2024

Gestational diabetes mellitus (GDM) has been found to be a common complication in pregnant women, known escalate the risk of negative obstetric outcomes. In our study, we genotyped 1,566 Chinese women for two single nucleotide polymorphisms (SNPs) LINGO2 gene and one SNP GLIS3 gene, utilizing targeted next-generation sequencing. The impact interacting genes, interaction genes with environment─including exposure particulate matter (PM2.5), ozone (O3), variations prepregnancy body mass index (BMI)─on incidence GDM were analyzed using logistic regression. Our findings identify variants rs10968576 (P = 0.022, OR 1.224) rs1412239 0.018, 1.231), as well rs10814916 0.028, 1.172), mutations significantly linked increased susceptibility GDM. Further analysis underscores crucial role gene–gene gene–environment interactions development among < 0.05). Particularly, individuals carrying G-rs1412239 G-rs10814916 C haplotype exhibit during period when PM2.5, O3, BMI 8.004 × 10–7, 1.206; P 6.3264 10–11, 1.280; 9.928 1.334, respectively). conclusion, research emphasizes importance between specific variations─LINGO2 GLIS3─and environmental factors influencing risk. Notably, significant associations these across various periods.

Язык: Английский

Per- and Polyfluoroalkyl Substances and Female Health Concern: Gender-based Accumulation Differences, Adverse Outcomes, and Mechanisms DOI
Xin Li, Minmin Hou, Feng Zhang

и другие.

Environmental Science & Technology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 13, 2025

The deleterious health implications of perfluoroalkyl and polyfluoroalkyl substances (PFAS) are widely recognized. Females, in contrast to males, exhibit unique pathways for PFAS exposure excretion, leading complex outcomes. status females is largely influenced by hormone-related processes. have been reported be associated with various aspects female health, including reproductive system disorders pregnancy-related diseases. In this article, we provide insights into the correlations between female-prevalent Current epidemiological toxicological evidence has demonstrated that adverse effects on primarily attributed disruption hypothalamic-pituitary-gonadal (HPG) axis hormonal homeostasis. However, these findings do not sufficiently elucidate intricate associations specific Furthermore, autoimmune disorders, another category more prevalent women compared men, require additional investigation. Immune biomarkers pertinent observed exposure, although insufficient substantiate relations. Further thorough exploration encompassing studies essential elucidating inherent influence human pathologies. Additionally, comprehensive investigations issues beyond their functions essential.

Язык: Английский

Процитировано

2
Association between exposure to outdoor artificial light at night during pregnancy and glucose homeostasis: A prospective cohort study DOI
Lei Zhang, Haixia Wang,

Ping Zu

и другие.

Environmental Research, Год журнала: 2024, Номер 247, С. 118178 - 118178

Опубликована: Янв. 13, 2024

Язык: Английский

Процитировано

4
Exposure to phthalates and their alternatives in relation to biomarkers of inflammation and oxidative stress in adults: evidence from NHANES 2017–2018 DOI
Shihao Jin,

Shanshan Cui,

Xiaoyu Mu

и другие.

Environmental Science and Pollution Research, Год журнала: 2023, Номер 30(59), С. 123770 - 123784

Опубликована: Ноя. 22, 2023

Язык: Английский

Процитировано

9
The effect of per and polyfluoroalkyl substance (PFAS) exposure on gestational diabetes mellitus and its subclinical risk factors: A systematic review and meta-analysis protocol DOI Creative Commons
Abigail P. Bline, Lauren B. Ellis, Katherine E. Pelch

и другие.

Environment International, Год журнала: 2024, Номер 188, С. 108711 - 108711

Опубликована: Май 1, 2024

Multiple lines of evidence suggest that exposure to per- and polyfluoroalkyl substances (PFAS) may alter glucose homeostasis, particularly during pregnancy, affect risk for developing gestational diabetes mellitus (GDM). While previous systematic reviews have been conducted on this topic, they did not assess internal validity the included studies their search strategies were narrowly focused.

Язык: Английский

Процитировано

3
Impact of imidacloprid exposure on gestational hyperglycemia: A multi-omics analysis DOI Creative Commons
Juan Wen, Qiao Liu,

Shijie Geng

и другие.

Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 280, С. 116561 - 116561

Опубликована: Июнь 12, 2024

Imidacloprid (IMI), a commonly utilized neonicotinoid insecticide, has been identified to adversely impact glucose homeostasis. Pregnant women are believed be more sensitive toxins than non-pregnant women, and the of IMI exposure on gestational hyperglycemia remain unclear. To explore impact, pregnant mice fed high-fat diet were exposed different doses (0.06, 0.6, 6 mg/kg bw/day) by gavage. Glucose homeostasis-related parameters measured. The homeostasis influenced treatment was explored through integrating gut microbiota, metabolomic transcriptomic analysis. Results showed that IMI-H (6 notably restricted weight gain perturbed characterized reduced tolerance insulin sensitivity, alongside elevated levels fasting blood insulin. Multi-omics analysis revealed induced significant changes in richness composition microbiome. metabolite profiles serum samples cecal contents, transcriptome liver ileum all affected treatment. altered metabolites genes exhibited correlations with parameters. These differential implicated various metabolic pathways including bile secretion, glucagon signaling pathway, lipid metabolism, fatty acid metabolism. Significant observed between microbiota caecum metabolome as well transcriptome. For example, abundance Oscillibacter strongly correlated microflora-related (Icosenoic acid, Lysosulfatide, fluticasone) (Grin3b, Lifr, Spta1). Together, resulted microbial composition, along alterations certain associated process, which may promote hyperglycemia.

Язык: Английский

Процитировано

3
Association of Phenols, Parabens, and Their Mixture with Maternal Blood Pressure Measurements in the PROTECT Cohort DOI Creative Commons
Julia Varshavsky, John D. Meeker, Emily Zimmerman

и другие.

Environmental Health Perspectives, Год журнала: 2024, Номер 132(8)

Опубликована: Авг. 1, 2024

Phenols and parabens are two classes of high production volume chemicals that used widely in consumer personal care products have been associated with reproductive harm pregnancy complications, such as preeclampsia gestational diabetes. However, studies examining their influence on maternal blood pressure hypertension limited.

Язык: Английский

Процитировано

3
Effects of neonicotinoid pesticide exposure in the first trimester on gestational diabetes mellitus based on interpretable machine learning DOI

Dongxiang Pan,

Lihong Zhou, Changhui Mu

и другие.

Environmental Research, Год журнала: 2025, Номер unknown, С. 121168 - 121168

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
Pentachlorophenol exposure, plasma metabolomic markers, and gestational diabetes mellitus: Association and potential mediation analyses DOI Creative Commons
Juan Wen,

Shijie Geng,

Juan Mu

и другие.

Environmental Pollution, Год журнала: 2025, Номер 372, С. 126069 - 126069

Опубликована: Март 14, 2025

Язык: Английский

Процитировано

0
Correlation of perfluoroalkyl and polyfluoroalkyl substance levels during pregnancy with gestational diabetes mellitus: a systematic review and meta-analysis DOI Creative Commons
Dongying Wang, Ting Su,

Meiqi Zhan

и другие.

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Март 27, 2025

Abstract Background: Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are a major class of contaminants in recent years. Pregnant women more susceptible to the influence these compounds, which could heighten risk developing gestational diabetes mellitus (GDM). This study aims conduct an updated systematic review meta-analysis determine correlation between PFAS exposure during pregnancy GDM delve into their dose-response relationship. Methods: Pubmed, EMBASE, Web Science, Cochrane Library databases were searched. Data statistically analyzed using Stata 15.0. Fixed-effects (FEM) or random-effects (REM) models used combine STD mean difference (SMD) odds ratio (OR) 95% confidence intervals (CIs) according heterogeneity. Dose-response meta-analyses performed when applicable. Results: A total 12 papers included this study. Meta-analysis results indicated significantly higher levels PFOA, PFBS, PFUnDA patients compared healthy pregnant women. exposed high PFOA PFBS had increased GDM, with ORs 1.513 1.436, respectively. analyses that for each 1 ng/ml increase exposure, by 0.3% 11.7%, In contrast, no significant associations observed other such as PFNA, PFHxS, PFOS, development GDM. Subgroup suggested PFOS from China those Western countries. The differences normal pronounced late pregnancy. Conclusion: Exposure is associated Given elevated risk, particularly Chinese population, it crucial reduce substances, especially preconception period onward.

Язык: Английский

Процитировано

0
Correlation of perfluoroalkyl and polyfluoroalkyl substance levels during pregnancy with gestational diabetes mellitus: a systematic review and meta-analysis DOI Creative Commons
Dongying Wang, Ting Su,

Meiqi Zhan

и другие.

BMC Pregnancy and Childbirth, Год журнала: 2025, Номер 25(1)

Опубликована: Апрель 14, 2025

Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are a major class of contaminants in recent years. Pregnant women more susceptible to the influence these compounds, which could heighten risk developing gestational diabetes mellitus (GDM). This study aims conduct an updated systematic review meta-analysis determine correlation between PFAS exposure during pregnancy GDM delve into their dose-response relationship. Pubmed, EMBASE, Web Science, Cochrane Library databases were searched. Data statistically analyzed using Stata 15.0. Fixed-effects (FEM) or random-effects (REM) models used combine STD mean difference (SMD) odds ratio (OR) 95% confidence intervals (CIs) according heterogeneity. Dose-response meta-analyses performed when applicable. A total 12 papers included this study. Meta-analysis results indicated significantly higher levels PFOA, PFBS, PFUnDA patients compared healthy pregnant women. exposed high PFOA PFBS had increased GDM, with ORs 1.513 1.436, respectively. analyses that for each 1 ng/ml increase exposure, by 0.3% 11.7%, In contrast, no significant associations observed other such as PFNA, PFHxS, PFOS, development GDM. Subgroup suggested PFOS from China those Western countries. The differences normal pronounced late pregnancy. Exposure is associated Given elevated risk, particularly Chinese population, it crucial reduce substances, especially preconception period onward.

Язык: Английский

Процитировано

0