5-Fluorouracil in Combination with Calcium Carbonate Nanoparticles Loaded with Antioxidant Thymoquinone against Colon Cancer: Synergistically Therapeutic Potential and Underlying Molecular Mechanism

Antioxidants, Год журнала: 2024, Номер 13(9), С. 1030 - 1030

Опубликована: Авг. 25, 2024

Colon cancer is the third most common worldwide, with high mortality. Adverse side effects and chemoresistance of first-line chemotherapy 5-fluorouracil (5-FU) have promoted widespread use combination therapies. Thymoquinone (TQ) a natural compound potent antioxidant activity. Loading antioxidants into nano delivery systems has been major advance in enhancing their bioavailability to improve clinical application. Hence, this study aimed prepare optimal TQ-loaded calcium carbonate nanoparticles (TQ-CaCO3 NPs) investigate therapeutic potential underlying molecular mechanisms TQ-CaCO3 NPs 5-FU against colon cancer. Firstly, we developed purely aragonite CaCO3 facile mechanical ball-milling method. The pH-sensitive biocompatible sustained release properties were prepared using synthesized method (a high-speed homogenizer). vitro revealed that (15 μM) (7.5 inhibited CT26 cell proliferation migration, induced apoptosis cycle arrest G0/G1 phase, suppressed spheroid growth, exhibiting synergistic effect. Finally, network pharmacology docking results indicated targets crucial signaling pathways Therefore, combined could enhance anti-colon broader targets, warranting further application for treatment.

Язык: Английский

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Exploring the Therapeutic Potential of 5-Fluorouracil-Loaded Calcium Carbonate Nanoparticles Combined with Natural Compound Thymoquinone for Colon Cancer Treatment

Pharmaceutics, Год журнала: 2024, Номер 16(8), С. 1011 - 1011

Опубликована: Июль 30, 2024

Given the need for novel and effective therapies colon cancer, this study aimed to investigate effects of 5-fluorouracil-loaded calcium carbonate nanoparticles (5FU-CaCO

Язык: Английский

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Zirconium and cerium dioxide fabricated activated carbon-based nanocomposites for enhanced adsorption and photocatalytic removal of methylene blue and tetracycline hydrochloride

Environmental Research, Год журнала: 2024, Номер 261, С. 119720 - 119720

Опубликована: Авг. 7, 2024

Язык: Английский

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Green synthesis of silver nanoparticles by sweet cherry and its application against cherry spot disease

Heliyon, Год журнала: 2024, Номер 10(10), С. e31508 - e31508

Опубликована: Май 1, 2024

Asia has a rich history of cultivating sweet cherries, practice that been carried out since ancient times. However, the effective management Alternaria disease in cherry crops presented formidable challenge, resulting notable decreases yield. Various attempts have made to employ both chemical and biological treatments; however, their effectiveness restricted. In order tackle this problem, an investigation was out, with primary objective isolating identifying

Язык: Английский

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Evaluating the Toxicity Profile of Green-Synthesized Ferric Nanoparticles Using Madhuca indica in a Zebrafish Model

Deleted Journal, Год журнала: 2025, Номер unknown

Опубликована: Май 2, 2025

Язык: Английский

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Antimicrobial efficiency against fish pathogens on the green synthesized silver nanoparticles

Microbial Pathogenesis, Год журнала: 2024, Номер 193, С. 106725 - 106725

Опубликована: Июнь 6, 2024

Язык: Английский

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Ecotoxic effect of mycogenic silver nanoparticles in water and soil environment

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Март 28, 2025

Abstract Silver nanoparticles (AgNPs) are one of the most widely used nanomaterials due to their antimicrobial properties. Among AgNPs synthesis methods, biological route has become preferable because its efficiency and eco-friendly character. Filamentous fungi can be successfully in biosynthesis AgNPs. The extensive application ever increasing production raise concerns about environmental safety. released during manufacturing processes or by leaching from AgNPs-supplemented products, then enter natural environment. Water soil ecosystems exposed presence. present study aimed at evaluating ecotoxicological potential derived Gloeophyllum striatum fungus. assessment was performed using organisms water ecosystems. Our results suggest that presence threaten inhabiting adverse effects differ depending on organism species. Freshwater crustacean Daphnia magna found sensitive among tested species with EC 50 values ranging 0.026–0.027 µg/mL after 48 h exposure. Crop plants were least affected above concentration range. Moreover, it noted varied scheme these differences visible case S. polyrhiza .

Язык: Английский

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Nanosilver Environmental Safety in Marine Organisms: Ecotoxicological Assessment of a Commercial Nano-Enabled Product vs an Eco-Design Formulation

Toxics, Год журнала: 2025, Номер 13(5), С. 338 - 338

Опубликована: Апрель 25, 2025

With the increasing use of manufactured nanomaterials in consumer products, especially silver nanoparticles (AgNPs), concerns about their environmental impact are rising. Two AgNP formulations were tested, commercial nanosilver product nanArgen™ and a newly eco-designed bifunctionalized (AgNPcitLcys), using marine organisms across three trophic levels, microalgae, microcrustaceans, bivalves. Acute toxicity was assessed on diatom Phaeodactylum tricornutum, brine shrimp larvae Artemia franciscana, bivalve Mytilus galloprovincialis. The behavior media, including stability concentration range (0.001-100 mg/L), also evaluated. Results showed that less stable compared to AgNpcitLcys, releasing more ions exhibiting higher microalgae (100% growth inhibition at 1 mg/L) microcrustaceans (>80% mortality 10 mg/L). Conversely, AgNPcitLcys (10 µg/L) toxic bivalves, possibly due smaller nanoparticle size affecting lysosomal membrane stability. This study highlights how eco-design, such as surface coating, influences toxicity. These findings emphasize importance eco-design minimizing impacts guiding development safer, sustainable nanomaterials.

Язык: Английский

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Green synthesis of nanoparticles using cottonwood and rambutan honeys: Optimization, characterization, and enhanced antioxidant activity with reduced toxicity via oligochitosan coating

Next Materials, Год журнала: 2025, Номер 8, С. 100685 - 100685

Опубликована: Апрель 28, 2025

Язык: Английский

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Silver Nanoparticles (AgNPs) as Potential Antiviral Agents: Synthesis, Biophysical Properties, Safety, Challenges and Future Directions─Update Review

Molecules, Год журнала: 2025, Номер 30(9), С. 2004 - 2004

Опубликована: Апрель 30, 2025

AgNPs have gained significant attention due to their unique physicochemical properties, making them valuable across a range of fields including medicine, textiles, and household products. With strong antimicrobial antiviral shown promise in treating infections, particularly wound care management. This review explores the mechanisms underlying activities AgNPs, as well methods used for synthesis, which include physical, chemical, biological approaches. The also addresses potential limitations cytotoxicity humans environment. interaction between microorganisms, viruses, varies based on synthesis particle morphology. As viral resistant strains, present major global health challenges, there is growing need alternative therapies. Metal nanoparticles like offer advantages over conventional drugs broad target range, reduces likelihood resistance development. highlights AgNPs’ effectiveness against variety such HIV, hepatitis B, respiratory syncytial virus, discusses use novel treatments. examines toxicity, offering insights into future therapeutic roles.

Язык: Английский

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