Overcoming key challenges: Next-generation synthetic anion transporters

Chem, Год журнала: 2025, Номер 11(1), С. 102394 - 102394

Опубликована: Янв. 1, 2025

Язык: Английский

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Uncovering the potent antimicrobial activity of squaramide based anionophores – chloride transport and membrane disruption

Chemical Science, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Squaramide derivatives that can efficiently bind to Cl − and exhibit potent transport in model liposomes demonstrate antimicrobial activity through a combination of disrupted chloride homeostasis membrane disruption.

Язык: Английский

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Anion transport in biologically relevant lipid mixtures

Chemical Communications, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

A potent squaramide-based anion transporter was used to evaluate how vesicles prepared with tailored lipid compositions, which mimic organelle membranes, can impact transmembrane transport.

Язык: Английский

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Design, synthesis and biological evaluation of Golgi-targeting anion transporters as inducers of Golgiphagy and apoptosis in cancer cells

European Journal of Medicinal Chemistry, Год журнала: 2025, Номер unknown, С. 117519 - 117519

Опубликована: Март 1, 2025

Язык: Английский

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Therapeutic synthetic anion transporters

Current Opinion in Chemical Biology, Год журнала: 2024, Номер 83, С. 102535 - 102535

Опубликована: Сен. 27, 2024

This short review highlights recent examples of small-molecule anion transporters reported in the literature that have potentially useful biological activity. includes anionophores with antibiotic or antifungal activity, anticancer potential to treat channelopathies such as cystic fibrosis. Additionally selective and targeted are also discussed.

Язык: Английский

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Illuminating anions in biology with genetically encoded fluorescent biosensors

Current Opinion in Chemical Biology, Год журнала: 2024, Номер 84, С. 102548 - 102548

Опубликована: Дек. 9, 2024

Язык: Английский

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