Chinese Science Bulletin (Chinese Version), Год журнала: 2025, Номер 70(10), С. 1446 - 1459
Опубликована: Янв. 22, 2025
Язык: Английский
Nature Aging, Год журнала: 2024, Номер 4(11), С. 1619 - 1634
Опубликована: Авг. 14, 2024
Aging is a complex process associated with nearly all diseases. Understanding the molecular changes underlying aging and identifying therapeutic targets for aging-related diseases are crucial increasing healthspan. Although many studies have explored linear during aging, prevalence of mortality risk accelerates after specific time points, indicating importance studying nonlinear changes. In this study, we performed comprehensive multi-omics profiling on longitudinal human cohort 108 participants, aged between 25 years 75 years. The participants resided in California, United States, were tracked median period 1.7 years, maximum follow-up duration 6.8 analysis revealed consistent patterns markers substantial dysregulation occurring at two major periods approximately 44 60 chronological age. Distinct molecules functional pathways these also identified, such as immune regulation carbohydrate metabolism that shifted 60-year transition cardiovascular disease, lipid alcohol 40-year transition. Overall, research demonstrates functions risks change nonlinearly across lifespan provides insights into biological involved
Язык: Английский
Процитировано
100
Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)
Опубликована: Сен. 23, 2024
Язык: Английский
Процитировано
28
Cell, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
The factors shaping human microbiome variation are a major focus of biomedical research. While other fields have used large sequencing compendia to extract insights requiring otherwise impractical sample sizes, the field has lacked comparably sized resource for 16S rRNA gene amplicon commonly quantify composition. To address this gap, we processed 168,464 publicly available gut samples with uniform pipeline. We use compendium evaluate geographic and technical effects on variation. find that regions such as Central Southern Asia differ significantly from more thoroughly characterized microbiomes Europe Northern America composition alone can be predict sample's region origin. also strong associations between primers DNA extraction. anticipate growing work, Human Microbiome Compendium, will enable advanced applied methodological
Язык: Английский
Процитировано
7
Cell Host & Microbe, Год журнала: 2024, Номер 32(8), С. 1280 - 1300
Опубликована: Авг. 1, 2024
Язык: Английский
Процитировано
17
Acta Pharmaceutica Sinica B, Год журнала: 2025, Номер 15(2), С. 1189 - 1192
Опубликована: Янв. 7, 2025
Язык: Английский
Процитировано
2
Gut Microbes, Год журнала: 2025, Номер 17(1)
Опубликована: Янв. 28, 2025
Hyperoxaluria, including primary and secondary hyperoxaluria, is a disorder characterized by increased urinary oxalate excretion could lead to recurrent calcium kidney stones, nephrocalcinosis eventually end stage renal disease. For high dietary (HDOx) or its precursors intake key reason. Recently, accumulated studies highlight the important role of gut microbiota in regulation homeostasis. However, underlying mechanisms involving metabolite disruptions hyperoxaluria remain poorly understood. Here, we investigated therapeutic efficacy fecal transplantation (FMT) sourced from healthy rats fed with standard pellet diet against excretion, damage (CaOx) crystal depositions via using rat models. We observed dose-dependent increases CaOx due accompanied significant reductions diversity shifts Ruminococcaceae_UCG-014 Parasutterella composition. Metabolomic analysis validated these findings, revealing substantial decreases metabolites associated microbial groups. Transplanting microbes effectively reduced HDOx-induced meanwhile restoring populations their metabolites. Furthermore, FMT treatment significantly decrease kidneys via, at least part, upregulating expressions intestinal barrier proteins transporters intestine. In conclusion, our study emphasizes effectiveness countering related These findings provide insights on complex connection between caused microbiota, offering promising avenues for targeted strategies.
Язык: Английский
Процитировано
2
Gene, Год журнала: 2024, Номер 933, С. 148923 - 148923
Опубликована: Сен. 6, 2024
Язык: Английский
Процитировано
8
Journal of Translational Medicine, Год журнала: 2024, Номер 22(1)
Опубликована: Окт. 15, 2024
The tumour microenvironment represents a novel frontier in oncological research. Over the past decade, accumulating evidence has underscored importance of (TME), including cells, stromal immune and various secreted factors, which collectively influence growth, invasion, responses to therapeutic agents. Immune cells within TME are now widely acknowledged play pivotal roles development treatment. While some perspectives have posited that facilitate progression confer resistance interventions, contrasting conclusions also exist. Affirmative negative appear be context dependent, unified consensus yet reached. burgeoning body research on relationship between gut microbiota tumours recent years led growing understanding. Most studies indicated specific components microbiota, such as unique bacterial communities or secretory diverse regulating TME, thereby influencing prognosis outcomes cancer treatments. A detailed understanding these factors could provide insights into therapy. In this study, we aimed synthesise information interactions providing an in-depth exploration potential guiding implications for future therapies.
Язык: Английский
Процитировано
8
Current Opinion in Microbiology, Год журнала: 2025, Номер 83, С. 102578 - 102578
Опубликована: Янв. 8, 2025
Язык: Английский
Процитировано
1
Clinical Reviews in Allergy & Immunology, Год журнала: 2025, Номер 68(1)
Опубликована: Фев. 15, 2025
Язык: Английский
Процитировано
1