Nonlinear dynamics of multi-omics profiles during human aging

Nature Aging, Journal Year: 2024, Volume and Issue: 4(11), P. 1619 - 1634

Published: Aug. 14, 2024

Aging is a complex process associated with nearly all diseases. Understanding the molecular changes underlying aging and identifying therapeutic targets for aging-related diseases are crucial increasing healthspan. Although many studies have explored linear during aging, prevalence of mortality risk accelerates after specific time points, indicating importance studying nonlinear changes. In this study, we performed comprehensive multi-omics profiling on longitudinal human cohort 108 participants, aged between 25 years 75 years. The participants resided in California, United States, were tracked median period 1.7 years, maximum follow-up duration 6.8 analysis revealed consistent patterns markers substantial dysregulation occurring at two major periods approximately 44 60 chronological age. Distinct molecules functional pathways these also identified, such as immune regulation carbohydrate metabolism that shifted 60-year transition cardiovascular disease, lipid alcohol 40-year transition. Overall, research demonstrates functions risks change nonlinearly across lifespan provides insights into biological involved

Language: Английский

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A systematic framework for understanding the microbiome in human health and disease: from basic principles to clinical translation

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Sept. 23, 2024

Language: Английский

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Integration of 168,000 samples reveals global patterns of the human gut microbiome

Cell, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

The factors shaping human microbiome variation are a major focus of biomedical research. While other fields have used large sequencing compendia to extract insights requiring otherwise impractical sample sizes, the field has lacked comparably sized resource for 16S rRNA gene amplicon commonly quantify composition. To address this gap, we processed 168,464 publicly available gut samples with uniform pipeline. We use compendium evaluate geographic and technical effects on variation. find that regions such as Central Southern Asia differ significantly from more thoroughly characterized microbiomes Europe Northern America composition alone can be predict sample's region origin. also strong associations between primers DNA extraction. anticipate growing work, Human Microbiome Compendium, will enable advanced applied methodological

Language: Английский

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The central role of the gut microbiota in the pathophysiology and management of type 2 diabetes

Cell Host & Microbe, Journal Year: 2024, Volume and Issue: 32(8), P. 1280 - 1300

Published: Aug. 1, 2024

Language: Английский

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Harnessing gut microbial communities to unravel microbiome functions

Current Opinion in Microbiology, Journal Year: 2025, Volume and Issue: 83, P. 102578 - 102578

Published: Jan. 8, 2025

Language: Английский

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Gut microbiota modulation via fecal microbiota transplantation mitigates hyperoxaluria and calcium oxalate crystal depositions induced by high oxalate diet

Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)

Published: Jan. 28, 2025

Hyperoxaluria, including primary and secondary hyperoxaluria, is a disorder characterized by increased urinary oxalate excretion could lead to recurrent calcium kidney stones, nephrocalcinosis eventually end stage renal disease. For high dietary (HDOx) or its precursors intake key reason. Recently, accumulated studies highlight the important role of gut microbiota in regulation homeostasis. However, underlying mechanisms involving metabolite disruptions hyperoxaluria remain poorly understood. Here, we investigated therapeutic efficacy fecal transplantation (FMT) sourced from healthy rats fed with standard pellet diet against excretion, damage (CaOx) crystal depositions via using rat models. We observed dose-dependent increases CaOx due accompanied significant reductions diversity shifts Ruminococcaceae_UCG-014 Parasutterella composition. Metabolomic analysis validated these findings, revealing substantial decreases metabolites associated microbial groups. Transplanting microbes effectively reduced HDOx-induced meanwhile restoring populations their metabolites. Furthermore, FMT treatment significantly decrease kidneys via, at least part, upregulating expressions intestinal barrier proteins transporters intestine. In conclusion, our study emphasizes effectiveness countering related These findings provide insights on complex connection between caused microbiota, offering promising avenues for targeted strategies.

Language: Английский

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Population-specific differences in the human microbiome: Factors defining the diversity

Gene, Journal Year: 2024, Volume and Issue: 933, P. 148923 - 148923

Published: Sept. 6, 2024

Language: Английский

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Influence of the gut microbiota on immune cell interactions and cancer treatment

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Oct. 15, 2024

The tumour microenvironment represents a novel frontier in oncological research. Over the past decade, accumulating evidence has underscored importance of (TME), including cells, stromal immune and various secreted factors, which collectively influence growth, invasion, responses to therapeutic agents. Immune cells within TME are now widely acknowledged play pivotal roles development treatment. While some perspectives have posited that facilitate progression confer resistance interventions, contrasting conclusions also exist. Affirmative negative appear be context dependent, unified consensus yet reached. burgeoning body research on relationship between gut microbiota tumours recent years led growing understanding. Most studies indicated specific components microbiota, such as unique bacterial communities or secretory diverse regulating TME, thereby influencing prognosis outcomes cancer treatments. A detailed understanding these factors could provide insights into therapy. In this study, we aimed synthesise information interactions providing an in-depth exploration potential guiding implications for future therapies.

Language: Английский

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Where do the pathogens that cause surgical site infections come from?

Science Translational Medicine, Journal Year: 2024, Volume and Issue: 16(742)

Published: April 10, 2024

A study from Long et al. shows that many pathogens cause surgical site infections during spine surgery come the patient’s own microbiome, suggesting a paradigm shift in understanding of questions effectiveness current enhanced sterility and antibiotic protocols.

Language: Английский

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Decoding the diagnostic and therapeutic potential of microbiota using pan-body pan-disease microbiomics

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Sept. 26, 2024

Abstract The human microbiome emerges as a promising reservoir for diagnostic markers and therapeutics. Since host-associated microbiomes at various body sites differ diseases do not occur in isolation, comprehensive analysis strategy highlighting the full potential of should include diverse specimen types diseases. To ensure robust data quality comparability across diseases, we employ standardized protocols to generate sequencing from 1931 prospectively collected specimens, including saliva, plaque, skin, throat, eye, stool, with an average depth 5.3 gigabases. Collected 515 patients, these samples yield 3.7 metagenomes per patient. Our results suggest significant microbial variations types, unexpected anatomical sites. We identify 583 unexplored species-level genome bins (SGBs) which 189 are significantly disease-associated. Of note, existence resistance genes one was indicative same other specimens Annotated previously undescribed SGBs collectively harbor 28,315 biosynthetic gene clusters (BGCs), 1050 correlations combinatorial approach identifies distinct BGCs, emphasizing value pan-body pan-disease microbiomics source therapeutic strategies.

Language: Английский

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