Naphthyl‐Based Chalcone Derivatives: A Multifaceted Player in Medicinal Chemistry
ChemistrySelect,
Год журнала:
2024,
Номер
9(19)
Опубликована: Май 17, 2024
Abstract
Research
has
placed
a
great
deal
of
emphasis
on
molecule
development
and
discovery
with
substantial
biological
profiling
in
recent
years.
Despite
the
significant
side
effects,
medicinal
chemists
have
long
strived
to
synthesize
drug
molecules
highest
level
therapeutic
activity
lowest
possible
toxicity.
The
naphthyl‐based
chalcone
derivatives
drawn
attention
due
their
simple
structures
wide
range
pharmacological
effects.
main
focus
this
review
is
outline
biologically
active
based
naphthyl
moiety‐substituted
developed
over
A
synopsis
screening,
including
relevant
structure‐activity
relationships,
action
mechanisms,
applications,
provided
article.
It
true
that
prospective
hybrids
combining
moiety
different
pharmacophores
are
needed
address
resistance
improve
specificity.
Therefore,
may
be
useful
design
new,
highly
successful
drugs
previously
reported
methodologies.
Язык: Английский
In Vivo and In Silico Molecular Modeling Studies of Newly Synthesized Pyrazoles for Their Anti-Inflammatory and Analgesic Properties
Journal of Computational Biophysics and Chemistry,
Год журнала:
2024,
Номер
23(05), С. 623 - 640
Опубликована: Апрель 19, 2024
Background:
Pyrazole
derivatives
have
gained
attention
as
potential
leads
for
developing
anti-inflammatory
and
analgesic
drugs.
Chemical
modifications
of
pyrazole
structures
offer
a
strategy
to
enhance
their
therapeutic
properties,
while
minimizing
undesirable
effects.
Objective:
This
study
aimed
synthesize
novel
through
chemical
assess
activities.
Methods:
A
series
variants
were
synthesized
by
reacting
various
acetophenone
diethyl
oxalate
in
basic
conditions,
followed
treatment
with
glacial
acetic
acid
hydrazine
hydrate.
The
resulting
compounds
further
methylated
acetylated.
characterized
using
elemental
analysis,
1
H
NMR,
IR,
MASS
spectroscopy.
activity
was
evaluated
the
rat
paw
edema
technique
induced
carrageenan,
assessed
writhing
reflux
method.
Results:
Among
newly
derivatives,
3b,
3e
3g
′
demonstrated
significant
anti-
inflammatory
reduced
ulcerogenic
potential.
Compounds
3d,
3b
3d
exhibited
notable
compared
standard
drug.
introduced
these
confirmed
spectroscopic
analyses.
Conclusion:
findings
this
highlight
promising
candidates
drug
development.
structural
performed
research
improved
activities
compounds,
addressing
safety
concerns.
Further
investigations
are
warranted
elucidate
underlying
mechanisms
action
optimize
pharmacological
profiles
derivatives.
Язык: Английский
Path of Pyrazoles from Synthetic Factors to Anti-inflammatory Potential: A Review
Asian Journal of Chemistry,
Год журнала:
2024,
Номер
36(6), С. 1217 - 1231
Опубликована: Май 31, 2024
Pyrazoles,
a
class
of
heterocyclic
compounds,
have
garnered
considerable
attention
in
drug
development
due
to
their
intriguing
properties,
particularly
those
containing
pyrazole
moiety.
Pyrazole,
pivotal
chemical
the
creation
potent
bioactive
agents,
encompasses
five
members.
The
discovery
certain
compounds
exhibiting
robust
biological
activities
has
spurred
interest
this
field
inquiry.
Heterocyclic
incorporating
nitrogen
and
its
derivatives
historically
served
as
crucial
sources
medicinal
compounds.
Given
that
group
constitutes
vast
reservoir
organic
molecules,
significance
both
theoretical
applied
chemistry
grown
significantly.
Extensive
literature
indicates
researchers
employed
diverse
synthetic
strategies
recent
years
produce
substituted
with
promising
potential
anti-HIV,
anti-inflammatory,
antitumor
antimicrobial
agents.
Inflammation,
multifaceted
response
essential
for
body’s
defense
mechanisms,
can
also
contribute
various
pathological
conditions
when
dysregulated.
Understanding
underlying
molecular
mechanisms
offers
foundation
targeted
interventions
against
inflammatory
disorders.
These
insights
fuel
ongoing
endeavors
discover
effective
innovative
anti-inflammatory
agents
therapeutic
applications.
This
review
delves
into
synthesis
characterization
derivatives,
emphasizing
structural
modifications
influencing
efficacy.
provided
herein
are
invaluable
rational
design
novel
Furthermore,
concludes
discussion
on
future
perspectives,
underscoring
imperative
further
research
optimize
Язык: Английский