Molecules,
Год журнала:
2022,
Номер
27(13), С. 4159 - 4159
Опубликована: Июнь 29, 2022
The
greatest
challenge
in
the
analysis
of
herbal
components
lies
their
variety
and
complexity.
Therefore,
efficient
analytical
tools
for
separation
qualitative
quantitative
multi-components
are
essential.
In
recent
years,
various
emerging
techniques
have
offered
significant
support
complicated
component
analysis,
with
breakthroughs
selectivity,
sensitivity,
rapid
analysis.
Among
these
techniques,
supercritical
fluid
chromatography
(SFC)
has
attracted
much
attention
because
its
high
column
efficiency
environmental
protection.
SFC
can
be
used
to
analyze
a
wide
range
compounds,
including
non-polar
polar
making
it
prominent
platform.
applicability
determination
natural
products
medicines
is
overviewed
this
article.
applications
was
expanded
through
selection
optimization
stationary
phases
mobile
phases.
We
also
focus
on
two-dimensional
This
paper
provides
new
insight
into
method
development
medicine
Frontiers in Pharmacology,
Год журнала:
2022,
Номер
13
Опубликована: Март 9, 2022
Zanthoxylum
nitidum
(Roxb.)
DC.
(ZN),
with
strong
effects
of
anti-inflammation
and
antioxidant
activities
is
treated
as
a
core
herb
in
traditional
Chinese
medicine
(TCM)
preparation
for
treating
stomachache,
toothache,
rheumatoid
arthritis.
However,
the
active
ingredients
ZN
are
not
fully
clarified
due
to
its
chemical
complexity.
In
present
study,
double
spectrum-effect
analysis
strategy
was
developed
applied
explore
bioactive
components
herbs,
used
an
example.
Here,
were
rapidly
comprehensively
profiled
based
on
mass
defect
filtering-based
structure
classification
(MDFSC)
diagnostic
fragment-ion-based
extension
approaches.
Furthermore,
fingerprints
20
batches
samples
analyzed
by
high-performance
liquid
chromatography,
anti-inflammatory
studied.
Finally,
partial
least
squares
regression
(PLSR),
gray
relational
models,
Spearman's
rank
correlation
coefficient
(SRCC)
discover
compounds
ZN.
As
result,
total
48
identified
or
tentatively
characterized
ZN,
including
35
alkaloids,
seven
coumarins,
three
phenolic
acids,
two
flavonoids,
one
lignan.
The
results
achieved
prediction
models
indicated
that
peaks
4,
12,
17
potential
whereas
3,
5,
7,
13
involved
activity.
Among
them,
12
nitidine,
chelerythrine,
hesperidin,
oxynitidine
comparison
standards
other
references.
data
current
study
had
great
importance
improve
quality
standardization
method
might
be
efficiency
tool
discovery
complex
system,
such
TCMs.
Analytical Chemistry,
Год журнала:
2023,
Номер
95(26), С. 9940 - 9948
Опубликована: Июнь 14, 2023
Untargeted
mass
spectrometry
is
a
robust
tool
for
biology,
but
it
usually
requires
large
amount
of
time
on
data
analysis,
especially
system
biology.
A
framework
called
Multiple-Chemical
nebula
(MCnebula)
was
developed
herein
to
facilitate
the
LC–MS
analysis
process
by
focusing
critical
chemical
classes
and
visualization
in
multiple
dimensions.
This
consists
three
vital
steps
as
follows:
(1)
abundance-based
(ABC)
selection
algorithm,
(2)
classify
"features"
(corresponding
compounds),
(3)
Child-Nebulae
(network
graph)
with
annotation,
classification,
structure.
Notably,
MCnebula
can
be
used
explore
classification
structural
characteristic
unknown
compounds
beyond
limit
spectral
library.
Moreover,
intuitive
convenient
pathway
biomarker
discovery
because
its
function
ABC
visualization.
implemented
R
language.
series
tools
packages
were
provided
downstream
an
MCnebula-featured
way,
including
feature
selection,
homology
tracing
top
features,
enrichment
heat
map
clustering
information
query,
output
reports.
The
broad
utility
illustrated
human-derived
serum
set
metabolomics
analysis.
results
indicated
that
"Acyl
carnitines"
screened
out
biomarkers,
which
consistent
reference.
plant-derived
investigated
achieve
rapid
annotation
E.
ulmoides.
Frontiers in Microbiology,
Год журнала:
2022,
Номер
13
Опубликована: Июль 22, 2022
Gut
microbiota
is
a
complex
ecosystem
that
vital
for
the
development
and
function
of
immune
system,
closely
associated
with
host
immunity,
affects
human
health
disease.
Therefore,
current
progress
trends
in
this
field
must
be
explored.
No
bibliometric
analysis
has
been
conducted
on
gut
response.
This
study
aimed
to
analyze
developing
through
visual
analysis.
Global
publications
response
from
January
2011
December
2021
were
extracted
Web
Science
(WOS)
collection
database.
GraphPad
Prism,
VOSviewer
software,
CiteSpace
employed
perform
study.
The
number
rapidly
increased
last
decade
but
declined
most
recent
year.
Cooperation
network
shows
United
States,
Harvard
Medical
School,
Frontiers
Immunology
active
country,
institute,
journal
field,
respectively.
Co-occurrence
divided
all
keywords
into
four
clusters:
people,
animals,
cells,
diseases.
latest
keyword
within
clusters
was
"COVID,"
frequently
occurring
"SCFA."
remain
research
hotspot,
their
relation
cancer,
CNS
disorders,
autoimmune
disease
However,
additional
studies
performed,
particularly
its
association
bacterial
strain
screening
personalized
therapy.
