Monitoring and Managing Endocrine Disrupter Pesticides (EPDS) for Environmental Sustainability
Опубликована: Янв. 1, 2025
Язык: Английский
Direct Corona Charging: A New Strategy for Enhancing Sensitivity and Stability in Charged Aerosol Detection
Analytical Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 27, 2025
The
charged
aerosol
detector
(CAD)
is
widely
used
for
detecting
nonvolatile
compounds
without
UV
absorption
due
to
its
high
sensitivity,
stability,
and
consistent
response.
However,
the
traditional
plasma
collision
charging
mode
(PCCM)
suffers
from
issues
such
as
sample
dilution,
gas
flow
back-mixing,
disturbances,
which
reduce
sensitivity
repeatability.
To
address
these
limitations,
this
study
introduces
direct
corona
(DCCM),
eliminates
route
by
using
a
high-voltage
needle
directly
charge
dried
aerosol.
This
approach
avoids
mixing
collisions,
simplifies
instrument
structure,
reduces
nitrogen
consumption.
Comparative
analyses
samples
like
caffeine
demonstrated
that
DCCM
significantly
improves
stability
over
PCCM.
response
under
fits
quadratic
curve
with
correlation
coefficient
above
0.99
across
3
orders
of
magnitude.
Direct
injection
22
analytes
showed
achieved
peak
area
relative
standard
deviation
below
10%,
better
consistency
than
Gradient
analysis
complex
further
confirmed
DCCM's
superior
repeatability
sensitivity.
Real-sample
highlighted
DCCM-CAD's
practical
potential.
In
summary,
enhances
CAD
performance,
costs,
design,
paving
way
more
efficient
reliable
commercial
systems.
Язык: Английский
Phytochemistry, quality control and biosynthesis in ginseng research from 2021 to 2023: A state-of-the-art review concerning advances and challenges
Chinese Herbal Medicines,
Год журнала:
2024,
Номер
16(4), С. 505 - 520
Опубликована: Авг. 23, 2024
L.
(Araliaceae)
has
a
long
history
of
medicinal
and
edible
use
due
to
its
significant
tonifying
effects,
ginseng
research
been
hot
topic
in
natural
products
food
science.
In
continuation
our
recent
review,
we
highlighted
the
advances
from
2021
2023
with
157
citations,
which
exhibited
increasingly
systematic,
collaborative,
intelligent
characteristics.
this
firstly
updated
progress
phytochemistry
involving
ginsenosides
polysaccharides
summarized
researches
on
active
components.
Then,
some
specific
applications
by
feat
multidimensional
chromatography,
mass
spectrometry
imaging,
DNA
barcoding,
metabolomics,
were
analyzed,
could
provide
rich
information
supporting
multi-component
characterization,
authentication,
quality
control
versatile
products.
Finally,
biosynthesis
studies
concerning
retrospected.
Additionally,
current
challenges
future
trends
respect
discussed.
Язык: Английский
In-depth analysis of the acetylcholinesterase inhibitors of Ganoderma amboinense based receptor-ligand affinity coupled with complex chromatography
Journal of Food Composition and Analysis,
Год журнала:
2023,
Номер
125, С. 105776 - 105776
Опубликована: Окт. 20, 2023
Язык: Английский
Online Comprehensive Two-Dimensional Liquid Chromatography/Quadrupole Time-of-Flight Mass Spectrometry-Based Metabolic Profiling and Comparison Enabling the Characterization of 1146 Ginsenosides and More Explicit Differentiation of Ginseng
Journal of Agricultural and Food Chemistry,
Год журнала:
2024,
Номер
72(44), С. 24866 - 24878
Опубликована: Окт. 23, 2024
This
work
was
designed
for
the
in-depth
characterization
and
holistic
comparison
of
up
to
12
ginseng
varieties,
which
can
benefit
development
functional
foods
ensure
their
authenticity
in
food
industry.
An
online
comprehensive
two-dimensional
liquid
chromatography/quadrupole
time-of-flight
mass
spectrometry
(2D-LC/QTOF-MS)
approach
established
by
configurating
XCharge
C18
HSS
Cyano
columns.
Under
optimal
conditions,
we
characterized
a
total
1146
ginsenosides
(including
876
potentially
new
compounds)
from
varieties
reference
an
in-house
library
573
known
70
compounds.
The
2D-LC/QTOF-MS-based
untargeted
metabolomics
workflows
were
developed,
126
potential
ginsenoside
markers
unveiled
utilized
establish
key
identification
points
each
species.
Compared
with
conventional
chromatography/mass
metabolomics,
our
multidimensional
chromatography
performed
better
discriminating
multiple
varieties.
demonstrates
potent
practical
methodology
identify
easily
confused
plants.
Язык: Английский
Integration of ion mobility-quadrupole time-of-flight mass spectrometry and triple quadrupole-ion trap mass spectrometry coupled with ultra-high performance liquid chromatography for characterizing and quantitatively assay the saponins of Panax quinquefolius flower
Microchemical Journal,
Год журнала:
2024,
Номер
207, С. 112124 - 112124
Опубликована: Ноя. 9, 2024
Язык: Английский
Rapid screening and isolation of potential xanthine oxidase inhibitors in Ganoderma lucidum
Arabian Journal of Chemistry,
Год журнала:
2024,
Номер
17(9), С. 105925 - 105925
Опубликована: Июль 22, 2024
Given
the
abundance
and
intricate
nature
of
chemical
components
found
in
natural
food
ingredients,
functional
research
has
long
grappled
with
two
significant
technical
challenges:
rapid
precise
screening
active
substances
targeted
preparation.
To
enhance
efficiency
fungal
preparation,
novel
methodologies
for
production
xanthine
oxidase
inhibitors
from
G.
lucidum
have
been
developed.
The
were
rapidly
screened
using
AUF-LC-MS.
Molecular
docking
molecular
dynamics
simulation
used
to
verify
anti-gout
activity
compounds.
Subsequently,
as
guide,
HSCCC
SPLC
employed
separate
ingredients.
Simultaneously,
mechanism
action
was
analyzed
by
enzymatic
reaction
kinetics.
Finally,
verified
network
pharmacology,
its
discussed.
Four
potential
inhibitors,
namely
ganoderic
acid
C2,
B,
A,
D2,
lucidum.
Their
binding
energies
−6.29,
−6.65,
−4.29,
−5.96
kcal/mol,
respectively.
purity
four
triterpenoid
ingredients
isolated
more
than
90
%.
These
showed
a
reversible
inhibitory
effect
on
oxidase.
Network
pharmacological
studies
revealed
71
common
targets
gout,
obtained
intersecting
targets,
identified
main
metabolic
pathways.
results
indicate
that
extract
can
be
prevention
treatment
gout
disease.
We
compounds
preparation
incorporating
enzyme
inhibition
assays
computerized
virtual
compound
chromatography.
With
this
approach,
we
seamlessly
incorporate
fast
discovery,
screening,
focused
well
delving
into
mechanisms
monomers
proteases,
molecular-level
interactions
between
proteases.
This
study
providing
opportunities
discover
develop
new
therapeutics
health
resources.
Язык: Английский