Biosynthesis of Edible Terpenoids: Hosts and Applications
Foods,
Год журнала:
2025,
Номер
14(4), С. 673 - 673
Опубликована: Фев. 17, 2025
Microbial
foods
include
microbial
biomass,
naturally
fermented
foods,
and
heterologously
synthesized
food
ingredients
derived
from
fermentation.
Terpenoids,
using
isoprene
as
the
basic
structure,
possess
various
skeletons
functional
groups.
They
exhibit
diverse
physicochemical
properties
physiological
activities,
such
unique
flavor,
anti-bacterial,
anti-oxidant,
anti-cancer,
hypolipemic,
making
them
extensively
used
in
industry,
fragrance,
preservatives,
dietary
supplements,
medicinal
health
food.
Compared
to
traditional
strategies
like
direct
extraction
natural
species
chemical
synthesis,
cell
factories
for
edible
terpenoids
have
higher
titers
yields.
can
utilize
low-cost
raw
materials
are
easily
scaling-up,
representing
a
novel
green
sustainable
production
mode.
In
this
review,
we
briefly
introduce
synthetic
pathway
of
applications
producing
terpenoids.
Secondly,
highlight
several
typical
non-typical
chassis
terpenoid-producing
factories.
addition,
reviewed
recent
advances
representative
terpenoid
with
gram-scale
titer
preservation,
nutritional
enhancers,
foods.
Finally,
predict
future
directions
their
commercialization
process.
Язык: Английский
Comprehensive Review of Perilla frutescens: Chemical Composition, Pharmacological Mechanisms, and Industrial Applications in Food and Health Products
Foods,
Год журнала:
2025,
Номер
14(7), С. 1252 - 1252
Опубликована: Апрель 3, 2025
Perilla
frutescens
(L.)
Britt.,
a
multifunctional
herbaceous
plant,
is
widely
used
in
traditional
medicine
and
cuisine
due
to
its
rich
array
of
bioactive
compounds.
To
date,
many
key
phytochemicals
P.
have
been
identified,
including
volatile
terpenoids
(perillaldehyde,
limonene,),
flavonoids
(luteolin,
apigenin),
phenolic
acids
(rosmarinic
acid
derivatives),
which
exhibit
significant
antioxidant,
anti-inflammatory,
antiviral,
anticancer,
antibacterial,
blood
sugar-lowering
effects.
Studies
shown
that
oils,
flavonoids,
exert
their
effects
various
experimental
models.
In
food
industrial
applications,
shows
innovative
potential
functional
foods,
natural
preservatives,
novel
additives,
effectively
extending
shelf
life
providing
antimicrobial
protection.
Moreover,
research
on
the
biology
genetic
improvement
has
provided
new
approaches
enhance
yield
content.
Finally,
this
paper
also
discusses
safety
standardization
issues
theoretical
support
for
widespread
application.
Язык: Английский
Gas chromatographic techniques and spectroscopic approaches for a deep characterization of Piper gaudichaudianum Kunth essential oil from Brazil
Journal of Chromatography A,
Год журнала:
2024,
Номер
1732, С. 465208 - 465208
Опубликована: Июль 24, 2024
Piper
gaudichaudianum
Kunth
essential
oil
(EO)
is
a
natural
source
of
bioactive
components,
having
multiple
therapeutic
applications.
Its
chemical
composition
highly
variable,
and
strictly
depends
on
abiotic
factors,
resulting
in
various
biological
activities.
The
present
study
details
the
utilization
gas
chromatographic
techniques
alongside
nuclear
magnetic
resonance
(NMR)
spectroscopy
to
characterize
from
Brazil.
Seventy-six
components
were
identified
using
GC-MS
analysis,
while
enantio‑selective
multidimensional
chromatography
elucidated
enantiomeric
distribution
eight
chiral
for
first
time
literature.
Following
an
unidentified
component,
constituting
approximately
27
%
total
oil,
prompted
isolation
step
through
preparative
chromatography.
Through
combined
use
resonance,
GC-Fourier
transform
infrared
(FTIR),
mass
spectrometry
(MS),
unknown
molecule
was
structurally
as
4-[(3E)‑dec-3-en-1-yl]phenol.
Remarkably,
it
known
molecule,
gibbilimbol
B,
not
previously
listed
any
MS
database.
Subsequently,
spectrum
included
commercial
library,
specifically
FFNSC
4.0
database,
time.
Язык: Английский
Comparison of the efficacy of alginate nanoparticles containing Cymbopogon citratus essential oil and citral on melanoma and breast cancer cell lines under normoxic and hypoxic conditions
BMC Complementary Medicine and Therapies,
Год журнала:
2024,
Номер
24(1)
Опубликована: Окт. 19, 2024
Solid
tumors
often
develop
hypoxic
regions,
leading
to
aggressive
behavior
and
increased
drug
resistance.
The
chemical
composition
of
Cymbopogon
citratus
essential
oil
(EO)
was
analyzed
using
GC-MS.
Alginate
nanoparticles
containing
the
EO
its
primary
component,
citral,
were
synthesized
via
ionic
gelation
method.
Encapsulation
confirmed
ATR-FTIR
analysis.
anticancer
efficacy
C.
EO,
their
respective
alginate
evaluated
under
normoxic
(21%
oxygen)
(1%
conditions
on
breast
cancer
(MDA-MB-231)
melanoma
(A-375)
cell
lines.
Additionally,
qPCR
flow
cytometry
used
assess
apoptosis
gene
expression
ratios
(Bax/Bcl-2)
levels
apoptosis.
Citral
(80.98%)
identified
as
major
component
EO.
citral
(C.
citratus-AlgNPs
citral-AlgNPs)
with
particle
sizes
195
±
4
nm
222
9
nm,
zeta
potentials
-22
3
mV
−
17
1
mV,
respectively.
Both
samples
demonstrated
significantly
greater
conditions.
had
IC50
values
27
(19–39)
µg/mL
25
(4-147)
µg/mL,
respectively,
against
MDA-MB-231
A-375
cells.
Flow
showed
conditions,
highest
rates
observed
for
citral-AlgNPs
(84
5
92
5%
in
cells,
respectively).
This
study
demonstrates
that
enhance
activity
particularly
highlighting
potential
hypoxia-targeted
therapies.
Язык: Английский