Pharmaceutics,
Год журнала:
2022,
Номер
14(4), С. 872 - 872
Опубликована: Апрель 15, 2022
The
study
of
novel
drug
delivery
systems
represents
one
the
frontiers
biomedical
research
area.
Multi-disciplinary
scientific
approaches
combining
traditional
or
engineered
technologies
are
used
to
provide
major
advances
in
improving
bioavailability,
rate
release,
cell/tissue
specificity
and
therapeutic
index.
Biodegradable
bio-absorbable
polymers
usually
building
blocks
these
systems,
their
copolymers
employed
create
components.
For
example,
poly
(lactic
acid)
(glycolic
often
as
bricks
for
production
drug-based
polymeric
microparticles
(MPs)
micron-scale
needles.
To
avoid
time-consuming
empirical
optimization
formulations,
silico-supported
models
have
been
developed.
These
methods
can
predict
tune
release
different
drugs
starting
from
designed
combinations.
Starting
considerations,
this
review
has
aim
investigating
recent
carriers
combination
silico
experimental
promising
platforms
field.
Advances in Colloid and Interface Science,
Год журнала:
2021,
Номер
293, С. 102437 - 102437
Опубликована: Май 11, 2021
The
role
of
cosmetic
products
is
rapidly
evolving
in
our
society,
with
their
use
increasingly
seen
as
an
essential
contribution
to
personal
wellness.
This
suggests
the
necessity
a
detailed
elucidation
nanoparticles
(NPs)
cosmetics.
aim
present
work
offer
critical
and
comprehensive
review
discussing
impact
exploiting
nanomaterials
advanced
formulations,
emphasizing
beneficial
effects
extensive
next-generation
despite
persisting
prejudice
around
application
nanotechnology
discussion
here
includes
interpretation
data
underlying
generic
information
reported
on
product
labels
formulations
already
available
marketplace,
that
often
lacks
details
identifying
specific
components
product,
especially
when
are
employed.
emphasis
this
mainly
focused
skincare
because
it
believed
be
cosmetics
market
sector
which
being
most
significantly.
To
date,
has
been
demonstrated
improve
performance
number
different
ways:
1)
increasing
both
entrapment
efficiency
dermal
penetration
active
ingredient,
2)
controlling
drug
release,
3)
enhancing
physical
stability,
4)
improving
moisturizing
power,
5)
providing
better
UV
protection.
Specific
attention
paid
effect
contained
semisolid
skin
issues.
In
light
emerging
concerns
about
nanoparticle
toxicity,
entire
section
devoted
listing
examples
nanocosmetic
for
safety
investigated.
Acta Pharmaceutica Sinica B,
Год журнала:
2022,
Номер
13(10), С. 4105 - 4126
Опубликована: Ноя. 30, 2022
Messenger
RNA
(mRNA)
is
the
template
for
protein
biosynthesis
and
emerging
as
an
essential
active
molecule
to
combat
various
diseases,
including
viral
infection
cancer.
Especially,
mRNA-based
vaccines,
a
new
type
of
vaccine,
have
played
leading
role
in
fighting
against
current
global
pandemic
COVID-19.
However,
inherent
drawbacks,
large
size,
negative
charge,
instability,
hinder
its
use
therapeutic
agent.
Lipid
carriers
are
distinguishable
promising
vehicles
mRNA
delivery,
owning
capacity
encapsulate
deliver
negatively
charged
drugs
targeted
tissues
release
cargoes
at
desired
time.
Here,
we
first
summarized
structure
properties
different
lipid
carriers,
such
liposomes,
liposome-like
nanoparticles,
solid
lipid-polymer
hybrid
nanoemulsions,
exosomes
lipoprotein
particles,
their
applications
delivering
mRNA.
Then,
development
lipid-based
formulations
vaccine
delivery
systems
was
discussed
highlighted.
Recent
advancements
COVID-19
were
emphasized.
Finally,
described
our
future
vision
perspectives
this
field.
Journal of Materials Chemistry B,
Год журнала:
2022,
Номер
10(16), С. 2973 - 2994
Опубликована: Янв. 1, 2022
Traditional
Chinese
Medicine
(TCM)
has
been
applied
to
the
prevention
and
treatment
of
numerous
diseases
an
irreplaceable
role
in
rehabilitation
health
care.
However,
application
TCMs
is
drastically
limited
by
their
defects,
such
as
single
administration,
poor
water
solubility,
low
bioavailability,
weak
targeting
capability.
Recently,
nanoparticles
have
extensively
used
resolving
pharmaceutical
obstacles
consideration
large
specific
surface
area,
strong
capability,
good
sustained-release
effect,
etc.
In
this
review,
we
first
describe
limitations
TCM
ingredients
two
significant
forms
nanotechnology
TCM,
nanometerization
nano-drug
delivery
systems
for
TCMs.
Then,
discuss
preparation
methods
nanometerization:
mechanical
crushing,
spray
drying,
high-pressure
homogenization,
which
utilized
conquer
various
weaknesses
recent
advances
are
discussed,
including
lipid-based
nanocarriers,
polymeric
nanoparticles,
inorganic
hybrid
self-assembled
nanoparticles.
Finally,
future
challenges
perspectives
formula
complexity
nanocarriers
also
discussed.
Better
understanding
function
will
help
modernize
medicine
broaden
nano-TCM
clinic.
Biomedicines,
Год журнала:
2021,
Номер
9(12), С. 1909 - 1909
Опубликована: Дек. 14, 2021
Toxicity
caused
by
the
exposure
to
human-made
chemicals
and
environmental
conditions
has
become
a
major
health
concern
because
they
may
significantly
increase
formation
of
reactive
oxygen
species
(ROS),
negatively
affecting
endogenous
antioxidant
defense.
Living
systems
have
evolved
complex
mechanisms
protect
cells
from
oxidative
conditions.
Although
stress
contributes
various
pathologies,
intake
molecules
such
as
polyphenols,
obtained
natural
sources,
limit
their
effects
antimicrobial
properties
against
lipid
peroxidation
broad
range
foodborne
pathogens.
Ingestion
polyphenol-rich
foods,
fruits
vegetables,
help
reduce
harmful
ROS,
but
use
supramolecular
nanomaterials
delivery
emerged
an
efficient
method
improve
pharmacological
therapeutic
effects.
Suitable
exogenous
polyphenolic
antioxidants
should
be
readily
absorbed
delivered
sites
where
pathological
damage
take
place,
for
instance,
intracellular
locations.
Many
potential
poor
bioavailability,
can
encapsulated
ideal
solubility
permeability
profile.
Development
effective
strategies
requires
creation
new
nanoscale
drug
stress.
In
this
review
we
provide
overview
process,
highlight
some
discuss
role
polyphenols
bioactives
in
controlling
overproduction
ROS
bacterial
fungal
growth,
paying
special
attention
encapsulation
suitable
location
colloidal
interfaces
play
crucial
role.
Drug Delivery,
Год журнала:
2022,
Номер
29(1), С. 1007 - 1024
Опубликована: Апрель 1, 2022
This
review
provides
a
synthesis
of
the
last
ten
years
research
on
nanodelivery
systems
used
for
delivery
essential
oils
(EOs),
as
well
their
potential
viable
alternative
to
antibiotics
in
human
and
veterinary
therapy.
The
use
alone
therapy
is
not
always
possible
due
several
limitations
but
seem
be
able
overcome
these
issues.
choice
oil,
system
influences
therapeutic
efficacy
obtained.
While
studies
characterization
EOs
exist,
this
assesses
characteristics
nanomaterials
oils,
impact
functionality
nanodelivered
successful
applications.
Two
classes
stand
out:
polymeric
nanoparticles
(NPs)
including
chitosan,
cellulose,
zein,
sodium
alginate,
poly(lactic-co-glycolic)
acid
(PLGA),
lipidic
NPs
nanostructured
lipid
carriers,
solid
NPs,
nanoemulsions,
liposomes,
niosomes.
advantages
disadvantages
information
stability,
release,
are
covered
literature
presented
review,
information,
such
speed
emergence
bacteria
resistance
new
systems,
or
dosages
each
type
infection
animal
species
humans
still
missing
today.
Therefore,
more
quantitative
vivo
should
conducted
before
adoption
loaded
an
antibiotics,
where
appropriate.
