Chemistry of Materials,
Год журнала:
2022,
Номер
34(13), С. 6129 - 6141
Опубликована: Июнь 28, 2022
Bioprosthetic
cardiac
valves
are
efficient
replacements
to
clinically
treat
the
valvular
heart
diseases
including
stenosis
and
regurgitation,
while
these
often
suffer
from
issues
of
mechanical
mismatch,
biocompatibility,
thrombus,
degradation,
etc.
Here,
we
report
a
big
step
toward
biomechanically
compatible
hydrogel
by
reversible
addition–fragmentation
chain
transfer
polymerization
three-dimensional
(RAFT-3D)
printing
tough
hydrogels.
The
biocompatible
have
favorable
properties
matching
with
native
long-term
stability
durability
owing
wide
robust
hydrogen-bonding
networks,
on
which
heparin-like
polymer
−SO3–
is
readily
grafted
through
RAFT
polymerization,
endowing
outstanding
hemocompatibility
low
hemolysis,
anticoagulation,
acceptable
inflammatory
response.
proof-of-concept
aortic
valve
displayed
transvalvular
pressure
gradient
14–24
mmHg,
efficiently
regulates
flow
direction
regurgitation
and,
more
importantly,
endures
cyclic
∼80
mmHg
for
at
least
1.8
×
105
cycles
yet
maintaining
stable
without
any
damage
configuration
performance.
It
believed
that
engineered
pave
significant
way
addressing
complications
cardiovascular
diseases.
Molecules,
Год журнала:
2023,
Номер
28(4), С. 1963 - 1963
Опубликована: Фев. 18, 2023
Chitosan-based
nanoparticles
(chitosan-based
nanocomposites;
chitosan
nanoparticles;
ChNPs)
are
promising
materials
that
receiving
a
lot
of
attention
in
the
last
decades.
ChNPs
have
great
potential
as
nanocarriers.
They
able
to
encapsulate
drugs
well
active
compounds
and
deliver
them
specific
place
body
providing
controlled
release.
In
article,
an
overview
has
been
made
most
frequently
used
preparation
methods,
developed
applications
medicine.
The
presentation
important
information
concerning
ChNPs,
especially
chitosan’s
properties
drug
delivery
systems
(DDS),
method
NPs
production
was
quoted.
Additionally,
specification
classification
NPs’
morphological
features
determined
their
application
together
with
methods
attaching
NPs.
latest
scientific
reports
DDS
using
administered
orally,
through
eye,
on
skin
transdermally
were
taken
into
account.
Biomacromolecules,
Год журнала:
2022,
Номер
23(5), С. 1841 - 1863
Опубликована: Апрель 19, 2022
Synthetic
polymers
have
been
an
integral
part
of
modern
society
since
the
early
1960s.
Besides
their
most
well-known
applications
to
public,
such
as
packaging,
construction,
textiles
and
electronics,
synthetic
also
revolutionized
field
medicine.
Starting
with
first
plastic
syringe
developed
in
1955
complex
polymeric
materials
used
regeneration
tissues,
contributions
never
more
prominent.
Decades
research
on
materials,
stem
cells,
three-dimensional
printing
contributed
rapid
progress
tissue
engineering
regenerative
medicine
that
envisages
potential
future
organ
transplantations.
This
perspective
discusses
role
engineering,
design
properties
relation
each
type
application.
Additionally,
selected
recent
achievements
using
are
outlined
provide
insight
into
how
they
will
contribute
advancement
near
future.
In
this
way,
we
aim
a
guide
help
scientists
polymer
selection
for
different
applications.
Polymers,
Год журнала:
2022,
Номер
14(2), С. 351 - 351
Опубликована: Янв. 17, 2022
The
search
for
higher-quality
nanomaterials
medicinal
applications
continues.
There
are
similarities
between
electrospun
fibers
and
natural
tissues.
This
property
has
enabled
to
make
significant
progress
in
medical
applications.
However,
limited
tissue
scaffolding
When
nanoparticles
nanofibers
combined,
the
composite
material
can
perform
more
functions,
such
as
photothermal,
magnetic
response,
biosensing,
antibacterial,
drug
delivery
biosensing.
To
prepare
nanofiber
nanoparticle
hybrids
(NNHs),
there
two
primary
ways.
electrospinning
technology
was
used
produce
NNHs
a
single
step.
An
alternate
way
is
use
self-assembly
technique
create
fibers.
paper
describes
creation
of
from
routinely
biocompatible
polymer
composites.
Single-step
procedures
methodologies
discuss
preparation
NNHs.
It
combines
recent
research
discoveries
focus
on
application
release,
engineering
last
years.
Bioengineering & Translational Medicine,
Год журнала:
2022,
Номер
7(3)
Опубликована: Фев. 22, 2022
Mitigating
the
foreign
body
response
(FBR)
to
implantable
medical
devices
(IMDs)
is
critical
for
successful
long-term
clinical
deployment.
The
FBR
an
inevitable
immunological
reaction
IMDs,
resulting
in
inflammation
and
subsequent
fibrotic
encapsulation.
Excessive
fibrosis
may
impair
IMDs
function,
eventually
necessitating
retrieval
or
replacement
continued
therapy.
Therefore,
understanding
implant
design
parameters
their
degree
of
influence
on
pivotal
effective
long
lasting
IMDs.
This
review
gives
overview
as
well
anti-FBR
strategies.
Furthermore,
we
highlight
recent
advances
biomimetic
approaches
resist
FBR,
focusing
characteristics
potential
biomedical
applications.
Advances in Colloid and Interface Science,
Год журнала:
2023,
Номер
321, С. 103013 - 103013
Опубликована: Окт. 7, 2023
Hydroxyapatite
(HAp),
a
well-known
biomaterial,
has
witnessed
remarkable
evolution
over
the
years,
transforming
from
simple
biocompatible
substance
to
an
advanced
functional
material
with
wide
range
of
applications.
This
abstract
provides
overview
significant
advancements
in
field
HAp
and
its
journey
towards
becoming
multifunctional
material.
Initially
recognized
for
exceptional
biocompatibility
bioactivity,
gained
prominence
bone
tissue
engineering
dental
Its
ability
integrate
surrounding
tissues,
promote
cellular
adhesion,
facilitate
osseointegration
made
it
ideal
candidate
various
biomedical
implants
coatings.
As
understanding
grew,
researchers
explored
potential
beyond
traditional
biomaterial
With
advances
synthesis
engineering,
began
exhibit
unique
properties
that
extended
utility
other
disciplines.
Researchers
successfully
tailored
composition,
morphology,
surface
characteristics
HAp,
leading
enhanced
mechanical
strength,
controlled
drug
release
capabilities,
improved
biodegradability.
These
modifications
enabled
utilization
delivery
systems,
biosensors,
scaffolds,
regenerative
medicine
Moreover,
biomineralization
allowed
incorporation
ions
molecules
during
synthesis,
development
bioactive
coatings
composites
specific
therapeutic
functionalities.
functionalized
materials
have
demonstrated
promising
results
antimicrobial
coatings,
systems
growth
factors
agents,
even
as
catalysts
chemical
reactions.
In
recent
nanoparticles
nanostructured
emerged
focal
point
research
due
their
physicochemical
targeted
delivery,
imaging,
theranostic
The
manipulate
size,
shape,
chemistry
at
nanoscale
paved
way
innovative
approaches
personalized
therapies.
highlights
exploration
novel
methods,
modifications,
nanoengineering
techniques
expanded
horizon
applications,
enabling
integration
into
diverse
fields
ranging
biomedicine
catalysis.
Additionally,
this
manuscript
discusses
emerging
prospects
HAp-based
photocatalysis,
sensing,
energy
storage,
showcasing
realm
progresses,
future
holds
tremendous
revolutionize
medical
treatments
contribute
advancement
science
technology.
Chemical Society Reviews,
Год журнала:
2024,
Номер
53(8), С. 4086 - 4153
Опубликована: Янв. 1, 2024
This
review
critically
analyzes
degradable
biomedical
elastomers,
focusing
on
their
degradation,
synthesis,
microstructure,
and
role
in
tissue
repair.
It
guides
experts
balancing
degradation
with
repair
for
improved
applications.
Biomaterials Science,
Год журнала:
2023,
Номер
11(9), С. 3051 - 3076
Опубликована: Янв. 1, 2023
This
review
offers
systematic
considerations
of
material
design
principles
and
fabrication
techniques
for
biomimetic
skin
tissue
engineering
scaffolds.
