Biomechanically Compatible Hydrogel Bioprosthetic Valves DOI

Jiayu Wu,

Zhenyuan Wu,

Huajing Zeng

и другие.

Chemistry of Materials, Год журнала: 2022, Номер 34(13), С. 6129 - 6141

Опубликована: Июнь 28, 2022

Bioprosthetic cardiac valves are efficient replacements to clinically treat the valvular heart diseases including stenosis and regurgitation, while these often suffer from issues of mechanical mismatch, biocompatibility, thrombus, degradation, etc. Here, we report a big step toward biomechanically compatible hydrogel by reversible addition–fragmentation chain transfer polymerization three-dimensional (RAFT-3D) printing tough hydrogels. The biocompatible have favorable properties matching with native long-term stability durability owing wide robust hydrogen-bonding networks, on which heparin-like polymer −SO3– is readily grafted through RAFT polymerization, endowing outstanding hemocompatibility low hemolysis, anticoagulation, acceptable inflammatory response. proof-of-concept aortic valve displayed transvalvular pressure gradient 14–24 mmHg, efficiently regulates flow direction regurgitation and, more importantly, endures cyclic ∼80 mmHg for at least 1.8 × 105 cycles yet maintaining stable without any damage configuration performance. It believed that engineered pave significant way addressing complications cardiovascular diseases.

Язык: Английский

Chitosan-Based Nanoparticles as Effective Drug Delivery Systems—A review DOI Creative Commons

Karolina Jafernik,

Agata Ładniak, Eliza Blicharska

и другие.

Molecules, Год журнала: 2023, Номер 28(4), С. 1963 - 1963

Опубликована: Фев. 18, 2023

Chitosan-based nanoparticles (chitosan-based nanocomposites; chitosan nanoparticles; ChNPs) are promising materials that receiving a lot of attention in the last decades. ChNPs have great potential as nanocarriers. They able to encapsulate drugs well active compounds and deliver them specific place body providing controlled release. In article, an overview has been made most frequently used preparation methods, developed applications medicine. The presentation important information concerning ChNPs, especially chitosan’s properties drug delivery systems (DDS), method NPs production was quoted. Additionally, specification classification NPs’ morphological features determined their application together with methods attaching NPs. latest scientific reports DDS using administered orally, through eye, on skin transdermally were taken into account.

Язык: Английский

Процитировано

202

Biocompatible Synthetic Polymers for Tissue Engineering Purposes DOI
Zoi Terzopoulou, Alexandra Zamboulis, Ioanna Koumentakou

и другие.

Biomacromolecules, Год журнала: 2022, Номер 23(5), С. 1841 - 1863

Опубликована: Апрель 19, 2022

Synthetic polymers have been an integral part of modern society since the early 1960s. Besides their most well-known applications to public, such as packaging, construction, textiles and electronics, synthetic also revolutionized field medicine. Starting with first plastic syringe developed in 1955 complex polymeric materials used regeneration tissues, contributions never more prominent. Decades research on materials, stem cells, three-dimensional printing contributed rapid progress tissue engineering regenerative medicine that envisages potential future organ transplantations. This perspective discusses role engineering, design properties relation each type application. Additionally, selected recent achievements using are outlined provide insight into how they will contribute advancement near future. In this way, we aim a guide help scientists polymer selection for different applications.

Язык: Английский

Процитировано

144

Nanoparticle-based medicines in clinical cancer therapy DOI
Shuhang Wang, Keman Cheng, Kun Chen

и другие.

Nano Today, Год журнала: 2022, Номер 45, С. 101512 - 101512

Опубликована: Июнь 4, 2022

Язык: Английский

Процитировано

115

Polymer-Based Nanofiber–Nanoparticle Hybrids and Their Medical Applications DOI Open Access
Mingxin Zhang, Wenliang Song,

Yunxin Tang

и другие.

Polymers, Год журнала: 2022, Номер 14(2), С. 351 - 351

Опубликована: Янв. 17, 2022

The search for higher-quality nanomaterials medicinal applications continues. There are similarities between electrospun fibers and natural tissues. This property has enabled to make significant progress in medical applications. However, limited tissue scaffolding When nanoparticles nanofibers combined, the composite material can perform more functions, such as photothermal, magnetic response, biosensing, antibacterial, drug delivery biosensing. To prepare nanofiber nanoparticle hybrids (NNHs), there two primary ways. electrospinning technology was used produce NNHs a single step. An alternate way is use self-assembly technique create fibers. paper describes creation of from routinely biocompatible polymer composites. Single-step procedures methodologies discuss preparation NNHs. It combines recent research discoveries focus on application release, engineering last years.

Язык: Английский

Процитировано

97

Advanced strategies to thwart foreign body response to implantable devices DOI Creative Commons
Simone Capuani,

Gulsah Malgir,

Corrine Ying Xuan Chua

и другие.

Bioengineering & Translational Medicine, Год журнала: 2022, Номер 7(3)

Опубликована: Фев. 22, 2022

Mitigating the foreign body response (FBR) to implantable medical devices (IMDs) is critical for successful long-term clinical deployment. The FBR an inevitable immunological reaction IMDs, resulting in inflammation and subsequent fibrotic encapsulation. Excessive fibrosis may impair IMDs function, eventually necessitating retrieval or replacement continued therapy. Therefore, understanding implant design parameters their degree of influence on pivotal effective long lasting IMDs. This review gives overview as well anti-FBR strategies. Furthermore, we highlight recent advances biomimetic approaches resist FBR, focusing characteristics potential biomedical applications.

Язык: Английский

Процитировано

88

Hydroxyapatite: A journey from biomaterials to advanced functional materials DOI Creative Commons
Sudip Mondal, Sumin Park, Jaeyeop Choi

и другие.

Advances in Colloid and Interface Science, Год журнала: 2023, Номер 321, С. 103013 - 103013

Опубликована: Окт. 7, 2023

Hydroxyapatite (HAp), a well-known biomaterial, has witnessed remarkable evolution over the years, transforming from simple biocompatible substance to an advanced functional material with wide range of applications. This abstract provides overview significant advancements in field HAp and its journey towards becoming multifunctional material. Initially recognized for exceptional biocompatibility bioactivity, gained prominence bone tissue engineering dental Its ability integrate surrounding tissues, promote cellular adhesion, facilitate osseointegration made it ideal candidate various biomedical implants coatings. As understanding grew, researchers explored potential beyond traditional biomaterial With advances synthesis engineering, began exhibit unique properties that extended utility other disciplines. Researchers successfully tailored composition, morphology, surface characteristics HAp, leading enhanced mechanical strength, controlled drug release capabilities, improved biodegradability. These modifications enabled utilization delivery systems, biosensors, scaffolds, regenerative medicine Moreover, biomineralization allowed incorporation ions molecules during synthesis, development bioactive coatings composites specific therapeutic functionalities. functionalized materials have demonstrated promising results antimicrobial coatings, systems growth factors agents, even as catalysts chemical reactions. In recent nanoparticles nanostructured emerged focal point research due their physicochemical targeted delivery, imaging, theranostic The manipulate size, shape, chemistry at nanoscale paved way innovative approaches personalized therapies. highlights exploration novel methods, modifications, nanoengineering techniques expanded horizon applications, enabling integration into diverse fields ranging biomedicine catalysis. Additionally, this manuscript discusses emerging prospects HAp-based photocatalysis, sensing, energy storage, showcasing realm progresses, future holds tremendous revolutionize medical treatments contribute advancement science technology.

Язык: Английский

Процитировано

88

Chemical characterization of plasma-activated polymeric surfaces via XPS analyses: A review DOI
Rouba Ghobeira, Parinaz Saadat Esbah Tabaei, Rino Morent

и другие.

Surfaces and Interfaces, Год журнала: 2022, Номер 31, С. 102087 - 102087

Опубликована: Июнь 1, 2022

Язык: Английский

Процитировано

83

Degradable biomedical elastomers: paving the future of tissue repair and regenerative medicine DOI
Ben Jia,

Heyuan Huang,

Zhicheng Dong

и другие.

Chemical Society Reviews, Год журнала: 2024, Номер 53(8), С. 4086 - 4153

Опубликована: Янв. 1, 2024

This review critically analyzes degradable biomedical elastomers, focusing on their degradation, synthesis, microstructure, and role in tissue repair. It guides experts balancing degradation with repair for improved applications.

Язык: Английский

Процитировано

51

Nano-enhanced immunotherapy: Targeting the immunosuppressive tumor microenvironment DOI
Yuzhi Jin,

Yangyue Huang,

Hui Ren

и другие.

Biomaterials, Год журнала: 2024, Номер 305, С. 122463 - 122463

Опубликована: Янв. 6, 2024

Язык: Английский

Процитировано

50

Designing biomimetic scaffolds for skin tissue engineering DOI

Jiatian Chen,

Yingwei Fan,

Guozhao Dong

и другие.

Biomaterials Science, Год журнала: 2023, Номер 11(9), С. 3051 - 3076

Опубликована: Янв. 1, 2023

This review offers systematic considerations of material design principles and fabrication techniques for biomimetic skin tissue engineering scaffolds.

Язык: Английский

Процитировано

48