Lipid
membranes
form
the
primary
structure
of
cell
and
serve
as
configurable
interfaces
across
numerous
applications
including
biosensing
technologies,
antifungal
treatments,
therapeutic
platforms.
Therefore,
modification
lipid
by
additives
has
important
consequences
in
both
biological
processes
practical
applications.
In
this
study,
we
investigated
a
nicotinic-acid–based
gemini
surfactant
(NAGS)
chemically
tunable
molecular
additive
for
modulating
phase
behavior
liposomal
membranes.
We
specifically
focused
on
NAGS
with
hydrocarbon
chains
that
mirror
those
molecules.
By
introducing
to
phosphatidylcholine
lipids
identical
varied
chain
lengths
or
degrees
unsaturation,
demonstrated
effects
headgroup
interactions
mismatch
between
membrane
lipids.
Using
small-angle
X-ray
scattering,
showed
regardless
compatibility
mismatch,
reduced
thickness
packing
density
fluid
Further
observations
fluorescence
microscopy
revealed
emergence
ordered-disordered
domains
upon
cooling
room
temperature.
The
observed
phases
were
quite
distinct
from
analogous
compositions,
emphasizing
importance
chemistry
mediating
domain
formation
stabilization.
These
findings
open
new
possibilities
exploiting
tuning
organization
potential
drug
delivery
biomedical
imaging.
Molecules,
Год журнала:
2024,
Номер
29(11), С. 2544 - 2544
Опубликована: Май 28, 2024
Surfactants,
also
known
as
surface-active
agents,
have
emerged
an
important
class
of
compounds
with
a
wide
range
applications.
However,
the
use
chemical-derived
surfactants
must
be
restricted
due
to
their
potential
adverse
impact
on
ecosystem
and
health
human
other
living
organisms.
In
past
few
years,
there
has
been
growing
inclination
towards
natural-derived
alternatives,
particularly
microbial
surfactants,
substitutes
for
synthetic
or
chemical-based
counterparts.
Microbial
biosurfactants
are
abundantly
found
in
bacterial
species,
predominantly
Bacillus
spp.
Pseudomonas
The
chemical
structures
involve
complexation
lipids
carbohydrates
(glycolipoproteins
glycolipids),
peptides
(lipopeptides),
phosphates
(phospholipids).
Lipopeptides,
particular,
subject
extensive
research
versatile
properties,
including
emulsifying,
antimicrobial,
anticancer,
anti-inflammatory
properties.
This
review
provides
update
progress
classification
surfactants.
Furthermore,
it
explores
various
functionalities,
along
advantages
over
Finally,
applications
these
many
industries
insights
into
future
directions
discussed.
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Янв. 18, 2025
A
Gemini
cationic
surfactant
was
synthesized
through
an
aldehyde-amine
condensation
reaction
to
address
challenges
related
bacterial
corrosion
and
foaming
during
shale
gas
extraction.
This
treatment
agent
exhibits
sterilization,
mitigation,
properties.
The
mechanism
of
action
characterized
tests
measuring
surface
tension,
particle
size,
sterilization
efficacy,
mitigation
efficiency,
behavior.
Results
from
the
tension
test
indicate
that
at
60
°C,
surfactants
with
a
low
carbon
chain
structure
achieve
lowest
32.61
mN/m
critical
micelle
concentration.
Particle
size
distribution
(PSD)
reveal
within
1-10
concentration
range,
three
types
can
form
aggregates
self-assembly,
PSD
range
100-400
nm.
Antibacterial
performance
demonstrate
0.12
mmol/L
20-60
°C
achieves
bactericidal
rate
exceeding
99%,
maintained
even
after
24
h
contact.
effect
is
enhanced
under
acidic
alkaline
conditions.
Corrosion
show
50
reaches
optimal
value
over
70%.
Bubble
evaluation
results
suggest
1
exhibiting
resistance
mineralization
up
200
g/L.
development
this
establishes
foundation
for
effectively
addressing
issues
wellbore
fluid
encountered
in
wells.
Molecules,
Год журнала:
2023,
Номер
28(4), С. 1581 - 1581
Опубликована: Фев. 7, 2023
Recent
studies
indicate
that
surfactants
are
a
relatively
new
and
effective
class
of
corrosion
inhibitors
almost
entirely
meet
the
criteria
for
chemical
to
be
used
as
an
aqueous
phase
inhibitor.
They
possess
ideal
hydrophilicity
hydrophobicity
ratio,
which
is
crucial
interfacial
interactions.
In
this
study,
coconut-based
non-ionic
surfactant,
namely,
coco
monoethanolamide
(CMEA),
was
investigated
inhibition
behaviour
against
mild
steel
(MS)
in
1
M
HCl
employing
experimental
computational
techniques.
The
surface
morphology
studied
scanning
electron
microscope
(SEM),
atomic
force
(AFM),
contact
measurements.
critical
micelle
concentration
(CMC)
evaluated
0.556
mM
tension
corresponding
CMC
65.28
mN/m.
CMEA
manifests
best
efficiency
(η%)
99.01%
at
0.6163
(at
60
°C).
performs
mixed-type
inhibitor
its
adsorption
MS/1
interface
followed
Langmuir
isotherm.
theoretical
findings
from
density
functional
theory
(DFT),
Monte
Carlo
(MC),
molecular
dynamics
(MD)
simulations
accorded
with
findings.
MC
simulation’s
assessment
CMEA’s
high
energy
(−185
Kcal/mol)
proved
efficiently
spontaneously
adsorbs
interface.
Polymeric
systems
that
provide
cationic
charges
or
biocide-release
therapeutics
are
used
to
treat
the
bacteria-infected
wound.
However,
most
antibacterial
polymers
based
on
topologies
with
restricted
molecular
dynamics
still
do
not
satisfy
clinical
requirements
due
their
limited
efficacy
at
safe
concentrations
in
vivo.
Here
a
NO-releasing
topological
supramolecular
nanocarrier
rotatable
and
slidable
entities
is
reported
conformational
freedom
promote
interactions
between
carrier
pathogenic
microbes,
hence
greatly
improving
performance.
With
improved
contacting-killing
efficient
delivery
of
NO
biocide
from
molecularly
dynamic
ligand
design,
NO-loaded
achieves
excellent
anti-biofilm
effects
via
destroying
bacterial
membrane
DNA.
MRSA-infected
rat
model
also
brought
out
demonstrate
its
wound-healing
effect
neglectable
toxicity
Introducing
flexible
motions
into
therapeutic
polymeric
general
design
enhance
healing
range
diseases.
Medicinal Research Reviews,
Год журнала:
2024,
Номер
44(5), С. 2112 - 2193
Опубликована: Март 28, 2024
Abstract
Over
the
past
decade,
in
vivo
gene
replacement
therapy
has
significantly
advanced,
resulting
market
approval
of
numerous
therapeutics
predominantly
relying
on
adeno‐associated
viral
vectors
(AAV).
While
have
undeniably
addressed
several
critical
healthcare
challenges,
their
clinical
application
unveiled
a
range
limitations
and
safety
concerns.
This
review
highlights
emerging
challenges
field
therapy.
At
first,
we
discuss
both
role
biological
barriers
with
focus
AAVs,
current
landscape
human
We
delineate
advantages
disadvantages
AAVs
as
delivery
vehicles,
mostly
from
perspective
(hepatotoxicity,
cardiotoxicity,
neurotoxicity,
inflammatory
responses
etc.),
outline
mechanisms
adverse
events
response
to
AAV.
Contribution
every
aspect
AAV
(genomic
structure,
capsid
proteins)
host
injected
is
considered
substantiated
by
basic,
translational
studies.
The
updated
evaluation
recent
trials
medical
experience
clearly
shows
risks
that
sometimes
overshadow
hopes
for
curing
hereditary
disease.
last,
set
established
new
molecular
nanotechnology
tools
approaches
are
provided
potential
solutions
mitigating
or
eliminating
side
effects.
increasing
number
severe
reactions
and,
sadly
deaths,
demands
decisive
actions
resolve
issue
immune
extremely
high
doses
used
In
these
various
strategies
under
development,
including
aimed
at
augmenting
characteristics
others
focused
creating
secure
efficacious
non‐viral
vectors.
comprehensive
offers
an
overarching
present
state
utilizing
